Search Results - "Ouyang, Yeyun"
-
1
Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms
Published in eLife (22-01-2024)“…Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and…”
Get full text
Journal Article -
2
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
Published in eLife (17-08-2020)“…Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In…”
Get full text
Journal Article -
3
XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data
Published in PLoS computational biology (01-01-2020)“…Ribosome profiling, an application of nucleic acid sequencing for monitoring ribosome activity, has revolutionized our understanding of protein translation…”
Get full text
Journal Article -
4
Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-05-2021)“…Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major…”
Get full text
Journal Article -
5
Investigating the Regulation of Mitochondrial Membrane Potential
Published 01-01-2023“…Mitochondrial membrane potential plays an important role in regulating many essential cellular processes inside and outside mitochondria. Other than its most…”
Get full text
Dissertation -
6
ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly
Published in Molecular cell (16-08-2018)“…The electron transport chain (ETC) is an important participant in cellular energy conversion, but its biogenesis presents the cell with numerous challenges. To…”
Get full text
Journal Article -
7
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns
Published in Nature cell biology (01-04-2023)“…Metabolism is intertwined with various cellular processes, including controlling cell fate, influencing tumorigenesis, participating in stress responses and…”
Get full text
Journal Article -
8
Exploring the functional role of an ancient mitochondrial fatty acid synthesis pathway
Published in The FASEB journal (01-04-2019)“…Fatty acid synthesis plays a crucial role in the cellular energetic landscape. Cytoplasmic Fatty Acid Synthesis (FAS) generates fatty acid intermediates that…”
Get full text
Journal Article -
9
Callyspongiolide Is a Potent Inhibitor of the Vacuolar ATPase
Published in Journal of natural products (Washington, D.C.) (25-11-2020)“…Callyspongiolide is a marine-derived macrolide that kills cells in a caspase-independent manner. NCI COMPARE analysis of human tumor cell line toxicity data…”
Get full text
Journal Article -
10
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway
Published in Science advances (30-09-2022)“…The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial entry via the mitochondrial pyruvate carrier (MPC). We found…”
Get full text
Journal Article