Search Results - "Ouyang, Wenhao O."

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike by Tan, Timothy J. C., Mou, Zongjun, Lei, Ruipeng, Ouyang, Wenhao O., Yuan, Meng, Song, Ge, Andrabi, Raiees, Wilson, Ian A., Kieffer, Collin, Dai, Xinghong, Matreyek, Kenneth A., Wu, Nicholas C.

“…Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with…”
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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning by Lei, Ruipeng, Qing, Enya, Odle, Abby, Yuan, Meng, Gunawardene, Chaminda D., Tan, Timothy J. C., So, Natalie, Ouyang, Wenhao O., Wilson, Ian A., Gallagher, Tom, Perlman, Stanley, Wu, Nicholas C., Wong, Lok-Yin Roy

“…The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope…”
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Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity by Yuan, Meng, Feng, Ziqi, Lv, Huibin, So, Natalie, Shen, Ivana R., Tan, Timothy J.C., Teo, Qi Wen, Ouyang, Wenhao O., Talmage, Logan, Wilson, Ian A., Wu, Nicholas C.

“…The ability of the human immune system to generate antibodies to any given antigen can be strongly influenced by immunoglobulin V-gene allelic polymorphisms…”
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Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin by Lei, Ruipeng, Liang, Weiwen, Ouyang, Wenhao O., Hernandez Garcia, Andrea, Kikuchi, Chika, Wang, Shengyang, McBride, Ryan, Tan, Timothy J. C., Sun, Yuanxin, Chen, Chunke, Graham, Claire S., Rodriguez, Lucia A., Shen, Ivana R., Choi, Danbi, Bruzzone, Roberto, Paulson, James C., Nair, Satish K., Mok, Chris K. P., Wu, Nicholas C.

“…The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe…”
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Engineering an Oxygen‐Binding Protein for Photocatalytic CO2 Reductions in Water by Deng, Yunling, Dwaraknath, Sudharsan, Ouyang, Wenhao O., Matsumoto, Cory J., Ouchida, Stephanie, Lu, Yi

“…While native CO2‐reducing enzymes display remarkable catalytic efficiency and product selectivity, few artificial biocatalysts have been engineered to allow…”
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Engineering an Oxygen-Binding Protein for Photocatalytic CO 2 Reductions in Water by Deng, Yunling, Dwaraknath, Sudharsan, Ouyang, Wenhao O, Matsumoto, Cory J, Ouchida, Stephanie, Lu, Yi

“…While native CO -reducing enzymes display remarkable catalytic efficiency and product selectivity, few artificial biocatalysts have been engineered to allow…”
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Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase by Lei, Ruipeng, Kim, Wooseob, Lv, Huibin, Mou, Zongjun, Scherm, Michael J, Schmitz, Aaron J, Turner, Jackson S, Tan, Timothy J C, Wang, Yiquan, Ouyang, Wenhao O, Liang, Weiwen, Rivera-Cardona, Joel, Teo, Chuyun, Graham, Claire S, Brooke, Christopher B, Presti, Rachel M, Mok, Chris K P, Krammer, Florian, Dai, Xinghong, Ellebedy, Ali H, Wu, Nicholas C

“…There is growing appreciation for neuraminidase (NA) as an influenza vaccine target; however, its antigenicity remains poorly characterized. In this study, we…”
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Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning by Ouyang, Wenhao O, Tan, Timothy J C, Lei, Ruipeng, Song, Ge, Kieffer, Collin, Andrabi, Raiees, Matreyek, Kenneth A, Wu, Nicholas C

“…Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for COVID-19 vaccine development. While previous efforts largely focused…”
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Engineering an Oxygen‐Binding Protein for Photocatalytic CO2 Reductions in Water by Deng, Yunling, Dwaraknath, Sudharsan, Ouyang, Wenhao O., Matsumoto, Cory J., Ouchida, Stephanie, Lu, Yi

“…While native CO2‐reducing enzymes display remarkable catalytic efficiency and product selectivity, few artificial biocatalysts have been engineered to allow…”
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Engineering an Oxygen‐Binding Protein for Photocatalytic CO 2 Reductions in Water by Deng, Yunling, Dwaraknath, Sudharsan, Ouyang, Wenhao O., Matsumoto, Cory J., Ouchida, Stephanie, Lu, Yi

“…Abstract While native CO 2 ‐reducing enzymes display remarkable catalytic efficiency and product selectivity, few artificial biocatalysts have been engineered…”
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SARS-CoV-2 Wastewater Genomic Surveillance: Approaches, Challenges, and Opportunities by Munteanu, Viorel, Saldana, Michael, Ciorba, Dumitru, Bostan, Viorel, Su, Justin Maine, Kasianchuk, Nadiia, Sharma, Nitesh Kumar, Knyazev, Sergey, Gordeev, Victor, Aßmann, Eva, Lobiuc, Andrei, Covasa, Mihai, Crandall, Keith A, Ouyang, Wenhao O, Wu, Nicholas C, Mason, Christopher, Tierney, Braden T, Lucaci, Alexander G, Zelikovsky, Alex, Mohebbi, Fatemeh, Skums, Pavel, Gibas, Cynthia, Schlueter, Jessica, Rzymski, Piotr, Solo-Gabriele, Helena, Hölzer, Martin, Smith, Adam, Mangul, Serghei

“…During the SARS-CoV-2 pandemic, wastewater-based genomic surveillance (WWGS) emerged as an efficient viral surveillance tool that takes into account…”
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