Search Results - "Ouyang, Weiwei"

Feasibility of the inhibitor development for cancer: A systematic approach for drug design by Jiang, Yu, Liu, Ling, Geng, Yichao, Li, Qingsong, Luo, Daxian, Liang, Li, Liu, Wei, Ouyang, Weiwei, Hu, Jianping

“…The traditional Chinese medicine (TCM) bupleurum-ginger-licorice formula presents significant anti-cancer effects, but its active ingredients and inhibitory…”
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Appropriate delay of primary tumour radiotherapy may lead to better long-term overall survival for non-small cell lung cancer treated with EGFR-TKIs by Li, Qingsong, Liang, Na, Ouyang, Weiwei, Su, Shengfa, Ma, Zhu, Geng, Yichao, Hu, Yinxiang, Li, Huiqin, Lu, Bing

“…The most appropriate time of primary tumor radiotherapy in non-small cell lung cancer(NSCLC) with EGFR-TKIs remains unclear. The aim of this study was to…”
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NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions by Luo, Heyong, Zhou, Yanhua, Zhang, Jing, Zhang, Yingchun, Long, Shiqi, Lin, Xiaojin, Yang, Anqing, Duan, Jiangyao, Yang, Na, Yang, Zhiru, Che, Qiyuan, Yang, Yuxin, Guo, Ting, Zi, Dan, Ouyang, Weiwei, Yang, Wei, Zeng, Zhu, Zhao, Xing

“…Exosomes are membranous vesicles actively secreted by almost all cells and they deliver certain intracellular molecules, including nucleic acids, proteins, and…”
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Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation by Wu, Tingting, Cheng, Hu, Sima, Lijie, Wang, Zhongyuan, Ouyang, Weiwei, Wang, Jianta, Hou, Yunlei, Zhao, Dongsheng, Liao, Weike, Hu, Chujiao

“…The PD-1/PD-L1 pathway is considered as one of the most promising immune checkpoints in tumour immunotherapy. However, researchers are faced with the inherent…”
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S288T mutation altering MmpL3 periplasmic domain channel and H-bond network: a novel dual drug resistance mechanism by Ge, Yutong, Luo, Qing, Liu, Ling, Shi, Quanshan, Zhang, Zhigang, Yue, Xinru, Tang, Lingkai, Liang, Li, Hu, Jianping, Ouyang, Weiwei

“…Context Mycobacterial membrane proteins Large 3 (MmpL3) is responsible for the transport of mycobacterial acids out of cell membrane to form cell wall, which…”
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Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus by Zhao, Xing, Ouyang, Weiwei, Chester, Cariad, Long, Shiqi, Wang, Nianxue, He, Zhixu

“…Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing…”
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Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway by Long, Shiqi, Gu, Yangzhuo, An, Yuanyuan, Lin, Xiaojin, Chen, Xiaoqing, Wang, Xianyao, Liao, Chunxiang, Ouyang, Weiwei, Wang, Nianxue, He, Zhixu, Zhao, Xing

“…Cetuximab has been approved for use for first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, treatment with…”
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Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial by Shi, Yuankai, Fang, Jian, Hao, Xuezhi, Zhang, Shucai, Liu, Yunpeng, Wang, Lin, Chen, Jianhua, Hu, Yi, Hang, Xiaosheng, Li, Juan, Liu, Chunling, Zhang, Yiping, Wang, Zhehai, Hu, Yanping, Gu, Kangsheng, Huang, Jian’an, Zhang, Liangming, Shan, Jinlu, Ouyang, Weiwei, Zhao, Yanqiu, Zhuang, Wu, Yu, Yan, Zhao, Jun, Zhang, Helong, Lu, Pei, Li, Weidong, Si, Meimei, Ge, Mingjing, Geng, Huaize

“…WX-0593 (Iruplinalkib) is a novel, highly selective oral ALK and ROS1 tyrosine kinase inhibitor (TKI). In this study, the safety, antitumor activity, and…”
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First-in-human phase I/Ib study of QL1706 (PSB205), a bifunctional PD1/CTLA4 dual blocker, in patients with advanced solid tumors by Zhao, Yuanyuan, Ma, Yuxiang, Zang, Aimin, Cheng, Ying, Zhang, Yiping, Wang, Xiangcai, Chen, Zhendong, Qu, Song, He, Jianbo, Chen, Chuanben, Jin, Chuan, Zhu, Dongyuan, Li, Qingshan, Liu, Xianling, Su, Wuyun, Ba, Yi, Hao, Yanrong, Chen, Junmin, Zhang, Guoping, Qu, Shenhong, Li, Yong, Feng, Weineng, Yang, Mengxiang, Liu, Baorui, Ouyang, Weiwei, Liang, Jin, Yu, Zhuang, Kang, Xiaoyan, Xue, Shilin, Yang, Guihong, Yan, Wei, Yang, Yingying, Liu, Zhi, Peng, Yufeng, Fanslow, Bill, Huang, Xian, Zhang, Li, Zhao, Hongyun

“…QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and…”
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Correction: Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus by Zhao, Xing, Ouyang, Weiwei, Chester, Cariad, Long, Shiqi, Wang, Nianxue, He, Zhixu

“…[This corrects the article DOI: 10.1371/journal.pone.0184816.]…”
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Effect of primary tumor volume on survival of concurrent chemoradiotherapy in stage IV non‐small cell lung cancer by Chen, Xiaxia, Zhang, Wei, Luo, Lan, Fu, Shimei, Cao, Dongdong, Su, Shengfa, Li, Qingsong, Yang, Wengang, Geng, Yichao, Lu, Bing, Ouyang, Weiwei

“…Objective To explore the survival effect of thoracic gross tumor volume (GTV) in three‐dimensional (3D) radiotherapy for stage IV non‐small cell lung cancer…”
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Three-Dimensional Radiation Therapy to the Primary Tumor With Concurrent Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer: Results of a Multicenter Phase 2 Study From PPRA-RTOG, China by Su, ShengFa, MD, Li, Tao, MD, Lu, Bing, MD, Wang, XiaoHu, MD, Li, JianCheng, MD, Chen, Ming, MD, Lu, You, MD, Bai, YuJu, MD, Hu, YinXiang, MD, Ouyang, WeiWei, MD, Ma, Zhu, MD, Li, QingSong, MD, Li, HuiQin, MD, Wang, Yu, MD

“…Purpose The aim of this prospective multi-institutional phase 2 study was to investigate disease control, survival outcomes, and toxicity after thoracic…”
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Recombinant human endostatin combined with radiotherapy promotes cardiomyocyte apoptosis in rats via TGFβ1/Smads/CTGF signaling pathway by Ouyang, Weiwei, Fu, Shimei, Zhao, Xing, Su, Shengfa, Zhang, Jun, Luo, Daxian, Liu, Lina, Ding, Wenjin, Cao, Dongdong, Liu, Likun, He, Zhixu, Lu, Bing

“…The aim of the present study was to investigate the efficacy of recombinant human endostatin (ES) (rh-ES) combined with radiation on rat cardiomyocyte…”
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Reasonable Timing of Radiotherapy for Stage IV Non-Small-Cell Lung Cancer During Targeted Therapy Based on Tumour Volume Change by Li, Qingsong, Liang, Na, Zhang, Xia, Zhang, Yi, Ouyang, Weiwei, Su, Shengfa, Ma, Zhu, Hu, Yinxiang, Geng, Yichao, Chen, Xiaxia, Lu, Bing

“…The aim of this study was to investigate the reasonable timing of radiotherapy for stage IV non-small-cell lung cancer (NSCLC) with EGFR-positive mutations…”
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A multicenter randomized trials to compare the bioequivalence and safety of a generic doxorubicin hydrochloride liposome injection with Caelyx ® in advanced breast cancer by Li, Yinjuan, Qi, Lu, Wang, Yu, Li, Yan, Lei, Chunpu, Zhang, Yingjuan, Cheng, Xiaoqiang, Liu, Ju, Bai, HaiHong, Zhao, Xia, Lv, Shuzhen, Xiong, Bingjun, Liu, Juan, Shi, Yehui, Zhou, Huan, Li, Hongtao, Liu, Lihong, Jiang, Hongchuan, Ouyang, Weiwei, Li, Xiaowen, Li, Yanping, Wang, Xinghe

“…To compare the pharmacokinetic (PK) bioequivalence (BE) and safety of a generic pegylated liposomal doxorubicin (PLD) formulation with the reference product…”
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Large-scale Isolation of Exosomes Derived from NK Cells for Anti-tumor Therapy by Luo, Heyong, Zhang, Jing, Yang, Anqing, Ouyang, Weiwei, Long, Shiqi, Lin, Xiaojin, Yang, Na, Yang, Zhiru, Zhang, Yingchun, Yang, Wei, Che, Qiyuan, Yang, Yuxin, Guo, Ting, Zhao, Xing

“…Exosomes are lipid bilayer-enclosed vesicles, actively secreted by cells, containing proteins, lipids, nucleic acids, and other substances with multiple…”
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Thermoseed hyperthermia treatment of mammary orthotopic transplantation tumors in rats and impact on immune function by Ouyang, Weiwei, Gao, Fuping, Wang, Lufang, Xie, Xiaoxue, Lei, Fenglin, Zhou, Jumei, Liao, Yuping, Zhong, Meizuo, Tang, Jintian

“…To evaluate the effect of thermoseed inductive heating on mammary orthotopic transplantation tumors and immunologic function in rats. Walker-256 tumor cells…”
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Control of dissolved H2 concentration enhances electron generation, transport and TCE reduction by indigenous microbial community by Ouyang, Weiwei, Huang, Yao, Li, Cui, Huang, Wenyi, Yuan, Songhu, Liu, Hui

“…Electrokinetic enhanced bioremediation (EK-Bio) is practical for trichloroethene (TCE) dechlorination because the cathode can produce a wide range of dissolved…”
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High-Order Association Mapping for Expression Quantitative Trait Loci by Qin, Huaizhen, Ouyang, Weiwei, Zhao, Jinying

“…Mapping expression quantitative trait loci (eQTLs) is an important avenue to identify putative genetic variants in regulatory regions. Famed eQTL mapping…”
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Identification and synergetic mechanism of TCE, H2 and O2 metabolic microorganisms in the joint H2/O2 system by Li, Cui, Xue, Chen, Ouyang, Weiwei, Liu, Minghui, Sun, Yingtao, Liu, Hui

“…The sole H2 and O2 usually promote chlorinated hydrocarbons (CHCs) biotransformation by several mechanisms, including reductive dechlorination and aerobic…”
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