Search Results - "Ouyang, Weiming"
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1
Inflammation, a Key Event in Cancer Development
Published in Molecular cancer research (01-04-2006)“…Several recent studies have identified nuclear factor-κB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in…”
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2
Erk1/2 Inactivation-Induced c-Jun Degradation Is Regulated by Protein Phosphatases, UBE2d3, and the C-Terminus of c-Jun
Published in International journal of molecular sciences (09-04-2021)“…Constitutive photomorphogenic 1 (COP1) is the ubiquitin E3 ligase that mediates degradation of c-Jun protein upon Erk1/2 inactivation. It remains unknown how…”
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3
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Published in The EMBO journal (23-07-2008)“…The target of rapamycin (TOR), as part of the rapamycin‐sensitive TOR complex 1 (TORC1), regulates various aspects of protein synthesis. Whether TOR functions…”
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4
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Published in Toxins (28-08-2023)“…Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF)…”
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5
Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo
Published in International journal of molecular sciences (14-07-2021)“…Proinflammatory cytokine production following infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is associated with poor clinical…”
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6
Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1
Published in Viruses (27-10-2023)“…Human immunodeficiency virus type 2 (HIV-2) is known to be less pathogenic than HIV-1. However, the mechanism(s) underlying the decreased HIV-2 pathogenicity…”
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7
The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability
Published in Scientific reports (12-02-2020)“…PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy…”
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8
Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs
Published in International journal of biological sciences (01-01-2015)“…Cold adaptation is a body's protective response to cold stress. Mild chronic intermittent cold (CIC) exposure has been used to generate animal models for cold…”
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9
Cyclooxygenase-2 Induction by Arsenite through the IKKβ/NFκB Pathway Exerts an Antiapoptotic Effect in Mouse Epidermal Cl41 Cells
Published in Environmental health perspectives (01-04-2007)“…Background: Arsenic contamination has become a major public health concern worldwide. Epidemiologic data show that long-term arsenic exposure results in the…”
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10
Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability
Published in Toxicology and applied pharmacology (01-09-2012)“…Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at…”
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11
Pb exposure attenuates hypersensitivity in vivo by increasing regulatory T cells
Published in Toxicology and applied pharmacology (01-12-2012)“…Pb is a common environmental pollutant affecting various organs. Exposure of the immune system to Pb leads to immunosuppression or immunodysregulation…”
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12
A New Murine Model for Gastrointestinal Anthrax Infection
Published in PloS one (18-06-2013)“…The scientific community has been restricted by the lack of a practical and informative animal model of gastrointestinal infection with vegetative Bacillus…”
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13
Cyclooxygenase-2 Induction by Arsenite Is through a Nuclear Factor of Activated T-cell-dependent Pathway and Plays an Antiapoptotic Role in Beas-2B Cells
Published in The Journal of biological chemistry (25-08-2006)“…Arsenite is a well known metalloid human carcinogen, and epidemiological evidence has demonstrated its association with the increased incidence of lung cancer…”
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14
PI-3K/Akt Pathway-Dependent Cyclin D1 Expression Is Responsible for Arsenite-Induced Human Keratinocyte Transformation
Published in Environmental health perspectives (01-01-2008)“…Background: Long-term exposure of arsenite leads to human skin cancer. However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be…”
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15
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor κB induced by UV radiation
Published in Cancer research (Chicago, Ill.) (01-08-2005)“…Abstract Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of carcinogenesis. However, the…”
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16
p85α Acts as a Novel Signal Transducer for Mediation of Cellular Apoptotic Response to UV Radiation
Published in Molecular and Cellular Biology (01-04-2007)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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17
Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor‐κB kinase β‐subunit‐/nuclear factor‐κB is critical for cyclooxygenase‐2 induction by benzo[a]pyrene in human bronchial epithelial cells
Published in Cancer science (01-09-2007)“…The carcinogenic effect of benzo[a]pyrene (B[a]P), presenting mainly in cigarette smoke and air pollution, has been well demonstrated both in vitro and…”
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18
A JNK1/AP-1–Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate–Induced Cell Transformation through Regulating Cell Cycle Progression
Published in Molecular cancer research (01-01-2008)“…Cyclooxygenase-2 (COX-2) is reported to be one of the early-response gene products induced by 12- O -tetradecanoylphorbol-13-acetate (TPA). However, the…”
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19
Genome wide mapping of Foxo1 binding-sites in murine T lymphocytes
Published in Genomics data (01-12-2014)“…The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells…”
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20
JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
Published in Carcinogenesis (New York) (01-04-2007)“…Activation of the signaling pathways leading to gene expression regulation is critical in the carcinogenic effects of nickel exposure. In the present study, we…”
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