Search Results - "Ouyang, Liang"

Journal of Medicinal Chemistry Collection: Drug Discovery in China by Yu, Bin, Ouyang, Liang

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Holographic superconductors in 4D Einstein-Gauss-Bonnet gravity by Qiao, Xiongying, OuYang, Liang, Wang, Dong, Pan, Qiyuan, Jing, Jiliang

“…A bstract We investigate the neutral AdS black-hole solution in the consistent D → 4 Einstein-Gauss-Bonnet gravity proposed in [K. Aoki, M.A. Gorji, and S…”
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Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions by Liao, Minru, Zhang, Jin, Wang, Guan, Wang, Leiming, Liu, Jie, Ouyang, Liang, Liu, Bo

“…Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but an effective targeted therapy has not been well-established so far…”
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An overview of Sirtuins as potential therapeutic target: Structure, function and modulators by Wang, Yijie, He, Jun, Liao, Mengya, Hu, Mingxing, Li, Wenzhen, Ouyang, Hongling, Wang, Xin, Ye, Tinghong, Zhang, Yiwen, Ouyang, Liang

“…Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in…”
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The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy by Liu, Yao, Wang, Xiaohui, Wang, Guan, Yang, Yushang, Yuan, Yong, Ouyang, Liang

“…The p53 gene, a well-known tumor suppressor gene, plays a crucial role in cell cycle regulation, DNA repair, cell differentiation, and apoptosis. MDM2 exerts…”
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Recent advances in the design and discovery of synthetic tyrosinase inhibitors by Li, Jin, Feng, Lu, Liu, Li, Wang, Fang, Ouyang, Liang, Zhang, Lan, Hu, Xiuying, Wang, Guan

“…Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. As…”
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Targeting autophagy-related protein kinases for potential therapeutic purpose by Xiang, Honggang, Zhang, Jifa, Lin, Congcong, Zhang, Lan, Liu, Bo, Ouyang, Liang

“…Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control…”
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Optimal credit period and lot size for deteriorating items with expiration dates under two-level trade credit financing by Wu, Jiang, Ouyang, Liang-Yuh, Cárdenas-Barrón, Leopoldo Eduardo, Goyal, Suresh Kumar

“…•The retailer takes an up-stream trade credit and offers a down-stream trade credit.•The trade credit increases not only sales but opportunity cost and default…”
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Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives by Zhang, Ya, Zhang, Jifa, Wang, Jiaxing, Chen, Hao, Ouyang, Liang, Wang, Yuxi

“…The development of small-molecule inhibitors targeting G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 5 (GRK5) for the…”
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Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy by Zhang, Lan, Li, Jingjing, Ouyang, Liang, Liu, Bo, Cheng, Yan

“…Highlights • We focus on the roles of the human Atg4 family in the LC3 conjugation system and their function in apoptosis. • We discuss the roles of Atg4…”
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Emerging strategies to overcome resistance to third-generation EGFR inhibitors by Shi, Kunyu, Wang, Guan, Pei, Junping, Zhang, Jifa, Wang, Jiaxing, Ouyang, Liang, Wang, Yuxi, Li, Weimin

“…Abstract Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth factor family, regulates cell proliferation and signal…”
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Optimal production lot with imperfect production process under permissible delay in payments and complete backlogging by Ouyang, Liang-Yuh, Chang, Chun-Tao

“…The traditional economic production quantity (EPQ) model assumes that the production products are all perfect. It is not always true in the real production…”
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Manufacturer's pricing and lot-sizing decisions for perishable goods under various payment terms by a discounted cash flow analysis by Chang, Chun-Tao, Ouyang, Liang-Yuh, Teng, Jinn-Tsair, Lai, Kuei-Kuei, Cárdenas-Barrón, Leopoldo Eduardo

“…In practice, a cash payment is a classical payment term, a credit payment is commonly applied to stimulate sales, and an advance payment is used to avoid order…”
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FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth by Niu, Mengmeng, Xu, Jing, Liu, Yang, Li, Yuhuang, He, Tao, Ding, Liangping, He, Yajun, Yi, Yong, Li, Fengtian, Guo, Rongtian, Gao, Ya, Li, Rui, Li, Luping, Fu, Mengyuan, Hu, Qingyong, Luo, Yangkun, Zhang, Chunyan, Qin, Kewei, Yi, Jianqiao, Yu, Shuhan, Yang, Jian, Chen, Hu, Wang, Liang, Li, Zhonghan, Dong, Biao, Qi, Shiqian, Ouyang, Liang, Zhang, Yujun, Cao, Yang, Xiao, Zhi-Xiong Jim

“…Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to…”
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Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy by Liu, Yun, Li, Yang, Wang, Yuxi, Lin, Congcong, Zhang, Dan, Chen, Juncheng, Ouyang, Liang, Wu, Fengbo, Zhang, Jifa, Chen, Lei

“…Abstract Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein tyrosine kinases that play an important role in the regulation…”
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An analytic study on the excited states of holographic superconductors by Qiao, Xiongying, Wang, Dong, OuYang, Liang, Wang, Mengjie, Pan, Qiyuan, Jing, Jiliang

“…Based on the Sturm-Liouville eigenvalue problem, we develop a general analytic technique to investigate the excited states of the holographic superconductors…”
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A note on “optimal replenishment policies for non-instantaneous deteriorating items with price and stock sensitive demand under permissible delay in payment” by Wu, Jiang, Skouri, Konstantina, Teng, Jinn-Tsair, Ouyang, Liang-Yuh

“…Soni 2013. Int. J. Prod. Econ., 146 (1), 259–268 proposed optimal replenishment policies for non-instantaneous deteriorating items (i.e., the product starts…”
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Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease by Zhang, Kai, Zhu, Shiou, Li, Jiamei, Jiang, Tingting, Feng, Lu, Pei, Junping, Wang, Guan, Ouyang, Liang, Liu, Bo

“…Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to the health of the elderly. The current…”
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Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers by Jiang, Tingting, Wang, Guan, Liu, Yao, Feng, Lu, Wang, Meng, Liu, Jie, Chen, Yi, Ouyang, Liang

“…Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are…”
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Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives by Liu, Jiaxi, Wu, Yongya, Meng, Sha, Xu, Ping, Li, Shutong, Li, Yong, Hu, Xiuying, Ouyang, Liang, Wang, Guan

“…Eukaryotic cells engage in autophagy, an internal process of self-degradation through lysosomes. Autophagy can be classified as selective or non-selective…”
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