Cardiac involvement in patients recovering from Delta Variant of COVID‐19: a prospective multi‐parametric MRI study

Cardiac involvement in patients recovering from Delta Variant of COVID‐19: a prospective multi‐parametric MRI study

Aims The cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 (COVID‐19) remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta Variant of COVID‐19 based on multi‐parametric cardiac magnetic resonance imaging (MRI). Meth...

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Published in:ESC Heart Failure Vol. 9; no. 4; pp. 2576 - 2584
Main Authors: Zhang, Lieguang, Wei, Xiaoyu, Wang, Huimin, Jiang, Rui, Tan, Zekun, Ouyang, Jienan, Li, Xiaodan, Lei, Chunliang, Liu, Hui, Liu, Jinxin
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01-08-2022
John Wiley and Sons Inc
Wiley
Subjects:
Contraindications
Contrast Media
coronavirus disease 2019
Coronaviruses
COVID-19
COVID-19 - complications
Delta Variant
Disease transmission
Edema
feature tracking
Female
Gadolinium
Humans
Laboratories
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Middle Aged
Musculoskeletal system
Myocarditis
Original
Prospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Software
T1 mapping
T2 mapping
Values
Netherlands
China
feature tracking
Delta Variant
T2 mapping
coronavirus disease 2019
T1 mapping
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Summary:Aims The cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 (COVID‐19) remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta Variant of COVID‐19 based on multi‐parametric cardiac magnetic resonance imaging (MRI). Methods and results We prospectively assessed patients recovering from Delta Variant of COVID‐19 using multi‐parametric cardiac magnetic resonance imaging (MRI) between June 2021 and July 2021. Comparison was made with 25 healthy controls. Forty‐four patients (median age 51 years, 28 women) recovering from Delta Variant were recruited and had a median time of 35 days between diagnosis and cardiac MRI. There were no patients with chest pain (0/44, 0%) and high sensitivity cardiac troponin T troponin elevation (median levels 2.20 pg/mL, IQR levels 0.85–4.40 pg/mL). Regarding the cardiac imaging findings, a total of 14 (32%) patients presented cardiac tissue feature abnormalities, and a total of 9 (20%) patients had a myocarditis‐like injury based on cardiac MRI 2018 Lake Louise criteria. When we further assessed the T1 and T2 mapping values for of patients' individual, abnormal raised global native T1, T2, and extracellular volume were seen in 6 (14%), 6 (14%), and 4 (9%) patients, respectively. Comparing with controls, the patients had lower LV global longitudinal strain and (−22.2 ± 2.8% vs. −24.6 ± 2.0%, P < 0.001) and global circumferential strain (−20.7 ± 6.8% vs. −24.3 ± 2.9%, P = 0.014), but higher global native T1 (1318.8 ± 55.5 ms vs. 1282.9 ± 38.1 ms, P = 0.006). Four (9%) patients presented myocardial late gadolinium enhancement with subepicardial pattern mostly common seen, and two (5%) patients presented pericardial enhancement. Conclusions The cardiac MRI could detect subclinical functional and myocardial tissue characteristic abnormalities in individuals who were recovering from Delta Variant without cardiac‐related clinical findings. The native T1 mapping and strain imaging may be a sensitive tool for the noninvasive detection of a subset of patients who are at risk for cardiac sequelae and more prone to myocardial damage in survivors with Delta Variant.
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ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13971