Search Results - "Ouyang, Changhan"

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission by Wang, Qilong, Zhang, Miao, Torres, Gloria, Wu, Shengnan, Ouyang, Changhan, Xie, Zhonglin, Zou, Ming-Hui

“…Metformin is a widely used antidiabetic drug that exerts cardiovascular protective effects in patients with diabetes. How metformin protects against…”
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The interplay between autophagy and apoptosis in the diabetic heart by Ouyang, Changhan, You, Jieyun, Xie, Zhonglin

“…Abstract Diabetic cardiomyopathy is characterized by ventricular dysfunction that occurs in diabetic patients independent of coronary artery disease,…”
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Adipose HuR protects against diet-induced obesity and insulin resistance by Li, Jingyuan, Gong, Li, Liu, Shaozhuang, Zhang, Yujie, Zhang, Chunmei, Tian, Mi, Lu, Huixia, Bu, Peili, Yang, Jianmin, Ouyang, Changhan, Jiang, Xiuxin, Wu, Jiliang, Zhang, Yun, Min, Qing, Zhang, Cheng, Zhang, Wencheng

“…Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many physiological processes. Obesity, as a worldwide healthcare…”
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Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo by Wu, Yue, Song, Ping, Zhang, Wencheng, Liu, Junhui, Dai, Xiaoyan, Liu, Zhaoyu, Lu, Qiulun, Ouyang, Changhan, Xie, Zhonglin, Zhao, Zhengxing, Zhuo, Xiaozhen, Viollet, Benoit, Foretz, Marc, Wu, Jiliang, Yuan, Zuyi, Zou, Ming-Hui

“…Nicotine acts on adipocytes to induce activation of AMPK, promoting excess lipolysis and weight loss but also the development of whole-body insulin resistance…”
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AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response by Li, Hongliang, Min, Qing, Ouyang, Changhan, Lee, Jiyeon, He, Chaoyong, Zou, Ming-Hui, Xie, Zhonglin

“…Lipid accumulation is a central event in the development of chronic metabolic diseases, including obesity and type 2 diabetes, but the mechanisms responsible…”
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Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway by Lei, Min, Guo, Xiying, Yao, Yue, Shu, Ting, Ren, Zhanhong, Yang, Xiaosong, Ouyang, Changhan, Chen, Qingjie, Liu, Chao, Liu, Xiufen

“…Cognitive impairment frequently coexists with diabetes. Trelagliptin is a once-weekly taking selective dipeptidyl peptidase-4 (DPP-4) inhibitor and a long-term…”
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The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation by Zhou, Qiaofeng, Guo, Xiying, Chen, Tu, Liu, Yumin, Ji, Huimin, Sun, Yixuan, Yang, Xiaosong, Ouyang, Changhan, Liu, Xiufen, Lei, Min

“…Celastrol, the primary constituent of Tripterygium wilfordii, has demonstrated neuroprotective properties in rats with dementia by reducing inflammation. A…”
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Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats by Guo, Xiying, Lei, Min, Zhao, Jiangyan, Wu, Min, Ren, Zhanhong, Yang, Xiaosong, Ouyang, Changhan, Liu, Xiufen, Liu, Chao, Chen, Qingjie

“…Background: One of the typical symptoms of diabetes mellitus patients was memory impairment, which was followed by gradual cognitive deterioration and for…”
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Diabetic nephropathy execrates epithelial-to-mesenchymal transition (EMT) via miR-2467-3p/Twist1 pathway by Xu, Yan, Ouyang, Changhan, Lyu, Dayin, Lin, Zhangmei, Zheng, Wencai, Xiao, Fan, Xu, Zhimin, Ding, Lexi

“…Although diabetic nephropathy (DN) is induced by a complicate interplay of multiple factors, the underlying mechanisms remain poorly characterized, even the…”
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Effects of DPP4 Inhibitors as Neuroprotective Drug on Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review by Yuan, Yuting, Zhang, Yue, Lei, Min, Guo, Xiying, Yang, Xiaosong, Ouyang, Changhan, Liu, Chao, Chen, Qingjie

“…Purpose. Type 2 diabetes mellitus is considered as one of the risk factors for cognitive impairment. DPP4 inhibitors are effective drugs for the treatment of…”
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Identification of key genes and pathways in atherosclerosis using integrated bioinformatics analysis by Li, Shihuan, Li, Suqin, Li, Qingjie, Zhou, Qiaofeng, Liao, Wenli, Yu, Liangzhu, Ouyang, Changhan, Xia, Hongli, Liu, Chao, Li, Mincai

“…Atherosclerosis (AS) is a chronic inflammatory disease that might induce severe cardiovascular events, such as myocardial infarction and cerebral infarction…”
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Attenuating Atherosclerosis through Inhibition of the NF-κB/NLRP3/IL-1β Pathway-Mediated Pyroptosis in Vascular Smooth Muscle Cells (VSMCs) by Li, Shihuan, Li, Qingjie, Zhou, Qiaofeng, Li, Suqin, Wang, Siqi, Yao, Qing, Ouyang, Changhan, Liu, Chao, Li, Mincai

“…Objective. We investigated the effects of resveratrol (Res) and MCC950 on the pyroptosis of vascular smooth muscle cells (VSMCs) and the potential pathway…”
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Research progress of brain organoids in the field of diabetes by Su, Ying, Liu, Aimei, Chen, Hongguang, Chen, Qingjie, Zhao, Bo, Gao, Runze, Zhang, Kangwei, Peng, Tie, Zhang, Zhenwang, Ouyang, Changhan, Zhu, Dan

“…Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological…”
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Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1 by Zhang, Tianran, Li, Hongxuan, Ouyang, Changhan, Cao, Guangqing, Gao, Jiangang, Wu, Jiliang, Yang, Jianmin, Yu, Nengwang, Min, Qing, Zhang, Cheng, Zhang, Wencheng

“…Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays…”
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Increased Neuromedin B is Associated with a Favorable Prognosis in Glioblastoma by Li, Suqin, Li, Shihuan, Li, Qingjie, Liu, Fei, Liao, Wenli, Yu, Liangzhu, Ouyang, Changhan, Xia, Hongli, Liu, Chao, Li, Mincai

“…Neuromedin B (NMB) is a neuropeptide that plays a key role in many physiological processes and is involved in the pathology of various diseases. Increased…”
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Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum by Ouyang, Changhan, Guo, Lianjun, Lu, Qing, Xu, Xulin, Wang, Hongxing

“…Cerebral ischemia causes an excess release of glutamate, which can injure neurons. The striatum is one of the important regions vulnerable to hypoxia and…”
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P2O-A4-5 Rosiglitazone prevents oxidative/nitrative stress, gliosis and memory deficits induced by intracerebroventricular injection of streptozotocin in rats by Ouyang Changhan, Wu Jiliang

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Apigenin inhibits proliferation and differentiation of cardiac fibroblasts through AKT/GSK3β signaling pathway by Kan, Hongshuang, Wang, Pengyu, Yang, Yayuan, Jia, Hongyu, Liu, Aimei, Wang, Miao, Ouyang, Changhan, Yang, Xiaosong

“…Salvia miltiorrhiza Bunge (S. miltiorrhiza) is an important Traditional Chinese herbal Medicine (TCM) used to treat cardio-cerebrovascular diseases. Based on…”
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Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression by Yao, Hongmin, Li, Jian, Liu, Zhixue, Ouyang, Changhan, Qiu, Yu, Zheng, Xiaoxu, Mu, Jing, Xie, Zhonglin

“…Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood…”
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P3O-A1-4 [6]-gingerol reduces cerebral ischemia/reperfusion injury in the hippocampus of rats via regulation of SGK1/GSK-3beta pathway by Cai Fei, Li Cairong, Wu Jiliang, Ouyang Changhan, Zheng Min

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