Search Results - "Ouwerkerk, Jan"

Phase I Pharmacokinetic and Pharmacodynamic Study of the Aurora Kinase Inhibitor Danusertib in Patients With Advanced or Metastatic Solid Tumors by STEEGHS, Neeltje, ESKENS, Ferry A. L. M, LAFFRANCHI, Bernard, DE JONGE, Maja J. A, GELDERBLOM, Hans, VERWEIJ, Jaap, NORTIER, Johan W. R, OUWERKERK, Jan, VAN NOORT, Conny, MARIANI, Mariangela, SPINELLI, Riccardo, CARPINELLI, Patrizia

“…Danusertib (PHA-739358) is a small-molecule pan-aurora kinase inhibitor. This phase I dose escalation study was conducted to evaluate safety and tolerability…”
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Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib by van Erp, Nielka P, Gelderblom, Hans, Karlsson, Mats O, Li, Jing, Zhao, Ming, Ouwerkerk, Jan, Nortier, Johan W, Guchelaar, Henk-Jan, Baker, Sharyn D, Sparreboom, Alex

“…Purpose: To evaluate the effects of ritonavir, a potent inhibitor of CYP3A4, on the steady-state pharmacokinetics of imatinib. Experimental Design: Imatinib…”
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Quantification of sunitinib in human plasma by high-performance liquid chromatography–tandem mass spectrometry by Minkin, Patton, Zhao, Ming, Chen, Zhaoyuan, Ouwerkerk, Jan, Gelderblom, Hans, Baker, Sharyn D.

“…A rapid, sensitive and specific method was developed and validated using LC/MS/MS for determination of sunitinib in human plasma. Sample preparation involved a…”
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Phase I Dose Escalation Study of Telatinib, a Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor 2 and 3, Platelet-Derived Growth Factor Receptor β, and c-Kit, in Patients With Advanced or Metastatic Solid Tumors by Eskens, Ferry A L M, Steeghs, Neeltje, Verweij, Jaap, Bloem, Johan L, Christensen, Olaf, van Doorn, Leni, Ouwerkerk, Jan, de Jonge, Maja J A, Nortier, Johan W R, Kraetzschmar, Joern, Rajagopalan, Prabhu, Gelderblom, Hans

“…Telatinib (BAY 57-9352) is an orally available tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR) -2, VEGFR-3, platelet-derived…”
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Elbow Flexion Contractures in Childhood in Obstetric Brachial Plexus Lesions: A Longitudinal Study of 20 Neurosurgically Reconstructed Infants with 8-Year Follow-up by van der Sluijs, Maaike J, van Ouwerkerk, Willem-Jan R, van der Sluijs, Johannes A, van Royen, Barend J

“…Little knowledge exists on the development of elbow flexion contractures in children with obstetrical brachial plexus lesion (OBPL). This study aims to…”
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Prevention and management of adverse events related to regorafenib by De Wit, Mieke, Boers-Doets, Christine B., Saettini, Alessandra, Vermeersch, Kristina, de Juan, Carmen Roncero, Ouwerkerk, Jan, Raynard, See-See, Bazin, Ashley, Cremolini, Chiara

“…Regorafenib is an oral multikinase inhibitor that has shown antitumor activity in a range of solid tumors. Based on data from phase III clinical trials,…”
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Oral Adverse Events Associated with Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in Renal Cell Carcinoma: A Structured Literature Review by Boers‐Doets, Christine B., Epstein, Joel B., Raber‐Durlacher, Judith E., Ouwerkerk, Jan, Logan, Richard M., Brakenhoff, Jan A., Lacouture, Mario E., Gelderblom, Hans

“…Learning Objectives After completing this course, the reader will be able to: Describe the oral manifestations that can appear with TKI/mTORI. Describe the…”
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Best practices in the management of toxicities related to anti-EGFR agents for metastatic colorectal cancer by Ouwerkerk, Jan, Boers-Doets, Christine

“…Abstract Purpose To provide oncology nurses with an overview of the toxicity management associated with the anti-epidermal growth factor receptor (EGFR)…”
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Central venous access related adverse events after trabectedin infusions in soft tissue sarcoma patients; experience and management in a nationwide multi-center study by Verboom, Michiel C, Ouwerkerk, Jan, Steeghs, Neeltje, Lutjeboer, Jacob, Martijn Kerst, J, van der Graaf, Winette T A, Reyners, Anna K L, Sleijfer, Stefan, Gelderblom, Hans

“…Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access…”
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Translation and linguistic validation of the FACT-EGFRI-18 quality of life instrument from English into Dutch by Boers-Doets, Christine B, Gelderblom, Hans, Lacouture, Mario E, Bredle, Jason M, Epstein, Joel B, Schrama, Natascha A.W.P, Gall, Helen, Ouwerkerk, Jan, Brakenhoff, Jan A.C, Nortier, Johan W.R, Kaptein, Ad A

“…Abstract Purpose The Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitor 18 (FACT-EGFRI-18) is a patient-reported outcomes…”
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Phase I Dose Escalation Study of Telatiiaib, a Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor 2 and 3, Platelet-Derived Growth Factor Receptor β, and β-Kit, in Patients With Advanced or Metastatic Solid Tumors by ESKENS, Ferry A. L. M, STEEGHS, Neeltje, RAJAGOPALAN, Prabhu, GELDERBLOM, Hans, VERWEIJ, Jaap, BLOEM, Johan L, CHRISTENSEN, Olaf, VAN DOORN, Leni, OUWERKERK, Jan, DE JONGE, Maja J. A, NORTIER, Johan W. R, KRAETZSCHMAR, Joern

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Knowledge of haematological toxicities amongst European nurses—a learning needs assessment by Foubert, Jan, Kearney, Nora, Ouwerkerk, Jan, Uhlenhopp, Mary, Vaessen, Giel

“…Haematological toxicities such as neutropenia, anaemia and thrombocytopenia have a significant impact on patients with cancer. They can have a life-threatening…”
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TITAN: modifying an innovative American program for use with a European audience by Ahlberg, Karin, Dielenseger, Pascale, Dolan, Shelley, Foubert, Jan, Munoz, Maria, Ouwerkerk, Jan, Uhlenhopp, Mary, Wujcik, Debra

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High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes by Kerbusch, Thomas, Huitema, Alwin D.R, Kettenes-van den Bosch, Jantien J, Keizer, H.Jan, Ouwerkerk, Jan, de Kraker, Jan, Beijnen, Jos H

“…A method using reversed-phase high-performance liquid chromatography (RP-HPLC) is described for the measurement of the stabilized activated metabolite of…”
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Cancer therapy-induced emesis: the nurse's perspective by Ouwerkerk, J

“…There have been significant improvements in the diagnosis and treatment of malignant tumours. However, recent advances in cytostatic therapy are associated…”
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A man with blisters on hand and feet by Gelderblom, A J Hans, van der Rhee, Jasper I, Ouwerkerk, Jan

“…A 41-year-old man with metastases of a gastrointestinal stroma tumour was treated with an angiogenesis inhibitor. He presented with a distinct painful…”
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Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers by MULDERS, T. M. T, KEIZER, H. J, OUWERKERK, J, VAN DER VELDE, E. A, BREIMER, D. D, MULDER, G. J

“…Several studies have suggested that the glutathione/glutathione S-transferase (GSH/GST) system is involved in resistance of tumors toward ifosfamide and other…”
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Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine by van Delft, J H, van den Ende, A M, Keizer, H J, Ouwerkerk, J, Baan, R A

“…An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating…”
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Psychologic aspects of the treatment of emesis in cancer nursing by Ouwerkerk, J, Keizer, H J

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Changing patterns of medical disease in Soweto, South Africa 1981-1990 by Gill, G V, Ouwerkerk, J

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