Search Results - "Ouwehand, Krista"

Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration by Ouwehand, Krista, Spiekstra, Sander W., Waaijman, Taco, Scheper, Rik J., Gruijl, Tanja D., Gibbs, Susan

“…New method to develop a human skin‐equivalent containing LC‐like cells in vitro, under conditions that mimic the natural tissue composition. In this report,…”
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CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis by Ouwehand, Krista, Santegoets, Saskia J.A.M, Bruynzeel, Derk P, Scheper, Rik J, de Gruijl, Tanja D, Gibbs, Susan

“…The initial step in Langerhans cell (LC) migration from the epidermis to the lymph node involves migration of maturing LC into the dermis. Here, we…”
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Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5 by Ouwehand, Krista, Scheper, Rik J, de Gruijl, Tanja D, Gibbs, Susan

“…Skin irritation is generally not considered to be an immunological event; however, alterations in the density of Langerhans cells (LC) in the epidermis do…”
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Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors by Verhaagh, Sandra, de Jong, Esmeralda, Goudsmit, Jaap, Lecollinet, Sylvie, Gillissen, Gert, de Vries, Margreet, van Leuven, Kees, Que, Ivo, Ouwehand, Krista, Mintardjo, Ratna, Weverling, Gerrit Jan, Radosevic, Katarina, Richardson, Jennifer, Eloit, Marc, Lowik, Clemens, Quax, Paul, Havenga, Menzo

“…1 Crucell Holland BV, Archimedesweg 4, 2333 CN Leiden, The Netherlands 2 Ecole National Veterinaire d'Alfort, Alfort, France 3 Gaubius Laboratory, TNO Leiden,…”
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Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins by Ouwehand, Krista, de Ruijter, Annemieke J.M., van Bree, Chris, Caron, Huib N., van Kuilenburg, André B.P.

“…Histone deacetylase inhibitors (HDACi) have been discovered as potential drugs for cancer treatment. The effect of BL1521, a novel HDACi, on the cell cycle…”
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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III by Alagramam, Kumar N, Gopal, Suhasini R, Geng, Ruishuang, Chen, Daniel H-C, Nemet, Ina, Lee, Richard, Tian, Guilian, Miyagi, Masaru, Malagu, Karine F, Lock, Christopher J, Esmieu, William R K, Owens, Andrew P, Lindsay, Nicola A, Ouwehand, Krista, Albertus, Faywell, Fischer, David F, Bürli, Roland W, MacLeod, Angus M, Harte, William E, Palczewski, Krzysztof, Imanishi, Yoshikazu

“…A small molecule identified from high-throughput screening and optimization specifically stabilizes a disease-linked CLRN1 protein, delivering it to its site…”
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Irritant-Induced Migration of Langerhans Cells Coincides with an IL-10-Dependent Switch to a Macrophage-Like Phenotype by Ouwehand, Krista, Oosterhoff, Dinja, Breetveld, Melanie, Scheper, Rik J., de Gruijl, Tanja D., Gibbs, Susan

“…Langerhans cells (LCs) migrate after topical exposure of the skin to irritants, despite the supposed independence of irritant contact dermatitis from adaptive…”
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CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents by Ouwehand, Krista, Spiekstra, Sander W., Waaijman, Taco, Breetveld, Melanie, Scheper, Rik J., de Gruijl, Tanja D., Gibbs, Susan

“…Epidermal Langerhans cells (LC) play a key role in initiation and regulation of immune responses. Whereas LC migration out of the epidermis upon environmental…”
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Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells by Ouwehand, Krista, Spiekstra, Sander W., Reinders, Judith, Scheper, Rik J., de Gruijl, Tanja D., Gibbs, Susan

“…As the induction of contact hypersensitivity is the result of a series of cellular processes, including maturation and migration of epidermal dendritic cells…”
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Irritant-Induced Migration of Langerhans Cells Coincides with an I L-10-Dependent Switch to a Macrophage-Like Phenotype by OUWEHAND, Krista, OOSTERHOFF, Dinja, BREETVELD, Melanie, SCHEPER, Rik J, DE GRUIJL, Tanja D, GIBBS, Susan

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Expression and immunogenicity of thePlasmodium falciparumcircumsporozoite protein: The role of GPI signal sequence by Ophorst, Olga JAE, Radosevic, Katarina, Ouwehand, Krista, van Beem, Wouter, Mintardjo, Ratna, Sijtsma, Jeroen, Kaspers, Jorn, Companjen, Arjen, Holterman, Lennart, Goudsmit, Jaap, Havenga, Menzo JE

“…Previous studies have shown that the immunogenicity of rodent malaria parasite-derived circumsporozoite protein (CS) can be improved by deleting the…”
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Expression and immunogenicity of the Plasmodium falciparum circumsporozoite protein: The role of GPI signal sequence by Ophorst, Olga J.A.E, Radošević, Katarina, Ouwehand, Krista, van Beem, Wouter, Mintardjo, Ratna, Sijtsma, Jeroen, Kaspers, Jorn, Companjen, Arjen, Holterman, Lennart, Goudsmit, Jaap, Havenga, Menzo J.E

“…Abstract Previous studies have shown that the immunogenicity of rodent malaria parasite-derived circumsporozoite protein (CS) can be improved by deleting the…”
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