Search Results - "Ouvrard‐Pascaud, Antoine"

Short‐ and long‐term administration of the non‐steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome‐related cardio‐renal dysfunction by Lachaux, Marianne, Barrera‐Chimal, Jonatan, Nicol, Lionel, Rémy‐Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anais, Wecker, Didier, Richard, Vincent, Kolkhof, Peter, Jaisser, Frederic, Ouvrard‐Pascaud, Antoine, Mulder, Paul

“…Aim To determine whether non‐steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome‐related end‐organ, i.e. cardiac, damage. Materials…”
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Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B‐deficient mice by Besnier, Marie, Galaup, Ariane, Nicol, Lionel, Henry, Jean‐Paul, Coquerel, David, Gueret, Alexandre, Mulder, Paul, Brakenhielm, Ebba, Thuillez, Christian, Germain, Stéphane, Richard, Vincent, Ouvrard‐Pascaud, Antoine

“…The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2…”
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Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models by Bonnard, Benjamin, Martínez-Martínez, Ernesto, Fernández-Celis, Amaya, Pieronne-Deperrois, Marie, Do, Quoc-Tuan, Ramos, Isbaal, Rossignol, Patrick, Zannad, Faiez, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia, Jaisser, Frédéric

“…Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological…”
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Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice by Pieronne‐Deperrois, Marie, Guéret, Alexandre, Djerada, Zoubir, Crochemore, Clément, Harouki, Najah, Henry, Jean‐Paul, Dumesnil, Anaïs, Larchevêque, Marine, Rego, Jean‐Claude, Rego, Jean‐Luc, Nicol, Lionel, Richard, Vincent, Jaisser, Frédéric, Kolkhof, Peter, Mulder, Paul, Monteil, Christelle, Ouvrard‐Pascaud, Antoine

“…Aims In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not…”
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Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction by Peschanski, Nicolas, Harouki, Najah, Soulie, Matthieu, Lachaux, Marianne, Nicol, Lionel, Remy‐Jouet, Isabelle, Henry, Jean‐Paul, Dumesnil, Anais, Renet, Sylvanie, Fougerousse, Françoise, Brakenhielm, Ebba, Ouvrard‐Pascaud, Antoine, Thuillez, Christian, Richard, Vincent, Roussel, Jérôme, Mulder, Paul

“…Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by…”
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Aldosterone promotes cardiac endothelial cell proliferation in vivo by Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic, Messaoudi, Smail

“…Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation through mineralocorticoid receptor…”
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Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction by Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Besnier, Marie, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Jaisser, Frédéric, Ouvrard-Pascaud, Antoine

“…Mineralocorticoid receptor (MR) antagonists slow down the progression of heart failure after myocardial infarction (MI), but the cell-specific role of MR in…”
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Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness by Galmiche, Guillaume, Pizard, Anne, Gueret, Alexandre, El Moghrabi, Soumaya, Ouvrard-Pascaud, Antoine, Berger, Stefan, Challande, Pascal, Jaffe, Iris Z., Labat, Carlos, Lacolley, Patrick, Jaisser, Frédéric

“…Arterial stiffness is recognized as a risk factor for many cardiovascular diseases. Aldosterone via its binding to and activation of the mineralocorticoid…”
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Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition by Ibarrola, Jaime, Matilla, Lara, Martínez-Martínez, Ernesto, Gueret, Alexandre, Fernández-Celis, Amaya, Henry, Jean-Paul, Nicol, Lionel, Jaisser, Frederic, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia

“…Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region, ischemia/reperfusion (IR) also initiates…”
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Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice by Bonnard, Benjamin, Pieronne-Deperrois, Marie, Djerada, Zoubir, Elmoghrabi, Soumaya, Kolkhof, Peter, Ouvrard-Pascaud, Antoine, Mulder, Paul, Jaisser, Frédéric, Messaoudi, Smail

“…Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a…”
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Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo by Messaoudi, Smail, Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Launay, Jean-Marie, Sierra-Ramos, Catalina, de la Rosa, Diego Alvarez, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic

“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice by Cattaneo, Monica, Aleksova, Aneta, Malovini, Alberto, Avolio, Elisa, Thomas, Anita, Alvino, Valeria Vincenza, Kilcooley, Michael, Pieronne-Deperrois, Marie, Ouvrard-Pascaud, Antoine, Maciag, Anna, Spinetti, Gaia, Kussauer, Sophie, Lemcke, Heiko, Skorska, Anna, Vasudevan, Praveen, Castiglione, Stefania, Raucci, Angela, David, Robert, Richard, Vincent, Beltrami, Antonio Paolo, Madeddu, Paolo, Puca, Annibale Alessandro

“…Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have shown that a…”
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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B by Gomez, Elodie, Vercauteren, Magali, Kurtz, Baptiste, Ouvrard-Pascaud, Antoine, Mulder, Paul, Henry, Jean-Paul, Besnier, Marie, Waget, Aurélie, Hooft Van Huijsduijnen, Rob, Tremblay, Michel L, Burcelin, Remy, Thuillez, Christian, Richard, Vincent

“…Abstract Protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase receptor-mediated responses, and especially negatively influences insulin…”
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Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression by Favre, Julie, Gao, Ji, Zhang, An Di, Remy-Jouet, Isabelle, Ouvrard-Pascaud, Antoine, Dautreaux, Brigitte, Escoubet, Brigitte, Thuillez, Christian, Jaisser, Frédéric, Richard, Vincent

“…The deleterious effects of aldosterone excess demonstrated in cardiovascular diseases might be linked in part to coronary vascular dysfunction. However,…”
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Conditional Transgenic Mice for Studying the Role of the Glucocorticoid Receptor in the Renal Collecting Duct by Nguyen Dinh Cat, Aurélie, Ouvrard-Pascaud, Antoine, Tronche, François, Clemessy, Maud, Gonzalez-Nunez, Daniel, Farman, Nicolette, Jaisser, Frederic

“…The mineralocorticoid receptor (MR) is a major regulator of renal sodium reabsorption and body fluid homeostasis. However, little is known about glucocorticoid…”
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Reversible Cardiac Fibrosis and Heart Failure Induced by Conditional Expression of an Antisense mRNA of the Mineralocorticoid Receptor in Cardiomyocytes by Beggah, Ahmed T., Escoubet, Brigitte, Puttini, Stefania, Cailmail, Stephane, Delage, Vanessa, Ouvrard-Pascaud, Antoine, Bocchi, Brigitte, Peuchmaur, Michel, Delcayre, Claude, Farman, Nicolette, Jaisser, Frederic

“…Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the reninangiotensin-aldosterone system has…”
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Managing cardio-renal-metabolic risk in patients with type 2 diabetes: the role of finerenone by Filardi, Tiziana, Feraco, Alessandra, Ouvrard-Pascaud, Antoine, Rizzo, Manfredi, Caprio, Massimiliano

“…•Diabetic kidney disease (DKD) develops in nearly 40% of patients with diabetes, and is a leading cause of end-stage renal disease…”
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Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB Pathway by Martínez-Martínez, Ernesto, Buonafine, Mathieu, Boukhalfa, Ines, Ibarrola, Jaime, Fernández-Celis, Amaya, Kolkhof, Peter, Rossignol, Patrick, Girerd, Nicolas, Mulder, Paul, López-Andrés, Natalia, Ouvrard-Pascaud, Antoine, Jaisser, Frédéric

“…Myocardial infarction (MI) is accompanied by cardiac fibrosis, which contributes to cardiac dysfunction. Mineralocorticoid receptor (MR) antagonists have…”
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Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure by Heron, Coraline, Dumesnil, Anais, Houssari, Mahmoud, Renet, Sylvanie, Lemarcis, Theo, Lebon, Alexis, Godefroy, David, Schapman, Damien, Henri, Orianne, Riou, Gaetan, Nicol, Lionel, Henry, Jean-Paul, Valet, Manon, Pieronne-Deperrois, Marie, Ouvrard-Pascaud, Antoine, Hagerling, Réné, Chiavelli, Hélène, Michel, Jean-Baptiste, Mulder, Paul, Fraineau, Sylvain, Richard, Vincent, Tardif, Virginie, Brakenhielm, Ebba

“…Lymphatics are essential for cardiac health, and insufficient lymphatic expansion (lymphangiogenesis) contributes to development of heart failure (HF) after…”
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Finerenone improves HFpEF in obese female mice and slows down its acceleration after a postmenopausal transition by Monmirel, Manon, Frimat, Coralie, Charrabi, Azzouz, Fauvel, Charles, Valet, Manon, Noel, Tony, Fernandes-Rosa, Fabio, Mulder, Paul, Fauconnier, Jérémy, Boulkroun, Sheerazed, Ouvrard-Pascaud, Antoine

“…Metabolic syndrome (MetS) and its related comorbidities significantly elevate the risk of heart failure with preserved ejection fraction (HFpEF), especially…”
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