Search Results - "Outten, Caryn E."

Monothiol CGFS Glutaredoxins and BolA-like Proteins: [2Fe-2S] Binding Partners in Iron Homeostasis by Li, Haoran, Outten, Caryn E

“…Monothiol glutaredoxins (Grxs) with a signature CGFS active site and BolA-like proteins have recently emerged as novel players in iron homeostasis. Elegant…”
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Iron sensing and regulation in Saccharomyces cerevisiae : Ironing out the mechanistic details by Outten, Caryn E, Albetel, Angela-Nadia

“…Highlights • Iron-dependent Aft1 nuclear export is not required for iron regulon deactivation. • High and low iron sensing depends on mitochondrial iron–sulfur…”
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The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix by Hu, Jingjing, Dong, Lixue, Outten, Caryn E.

“…Redox control in the mitochondrion is essential for the proper functioning of this organelle. Disruption of mitochondrial redox processes contributes to a host…”
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Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip by Ponsero, Alise J., Igbaria, Aeid, Darch, Maxwell A., Miled, Samia, Outten, Caryn E., Winther, Jakob R., Palais, Gael, D’Autréaux, Benoit, Delaunay-Moisan, Agnès, Toledano, Michel B.

“…In the endoplasmic reticulum (ER), Ero1 catalyzes disulfide bond formation and promotes glutathione (GSH) oxidation to GSSG. Since GSSG cannot be reduced in…”
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Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast by Toledano, Michel B, Delaunay-Moisan, Agnès, Outten, Caryn E, Igbaria, Aeid

“…The thioredoxin (TRX) and glutathione (GSH) pathways are universally conserved thiol-reductase systems that drive an array of cellular functions involving…”
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Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2 by Poor, Catherine B., Wegner, Seraphine V., Li, Haoran, Dlouhy, Adrienne C., Schuermann, Jonathan P., Sanishvili, Ruslan, Hinshaw, James R., Riggs-Gelasco, Pamela J., Outten, Caryn E., He, Chuan

“…The paralogous iron-responsive transcription factors Aft1 and Aft2 (a̱activators of f̱errous ṯransport) regulate iron homeostasis in Saccharomyces cerevisiae…”
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Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast by Li, Haoran, Mapolelo, Daphne T., Dingra, Nin N., Keller, Greg, Riggs-Gelasco, Pamela J., Winge, Dennis R., Johnson, Michael K., Outten, Caryn E.

“…The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces…”
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Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis by Kumánovics, Attila, Chen, Opal S., Li, Liangtao, Bagley, Dustin, Adkins, Erika M., Lin, Huilan, Dingra, Nin N., Outten, Caryn E., Keller, Greg, Winge, Dennis, Ward, Diane M., Kaplan, Jerry

“…The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the…”
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Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe-2S] cluster binding by Dlouhy, Adrienne C, Beaudoin, Jude, Labbé, Simon, Outten, Caryn E

“…The fission yeast Schizosaccharomyces pombe expresses the CCAAT-binding factor Php4 in response to iron deprivation. Php4 forms a transcription complex with…”
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Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR by Changela, Anita, Chen, Kui, Xue, Yi, Holschen, Jackie, Outten, Caryn E., O'Halloran, Thomas V., Mondragón, Alfonso

“…The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators…”
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Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis by Outten, Caryn E., O'Halloran, Thomas V.

“…Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range. To test this, we…”
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Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1 by Bouldin, Samantha D, Darch, Maxwell A, Hart, P John, Outten, Caryn E

“…The intramolecular disulfide bond in hSOD1 [human SOD1 (Cu,Zn superoxide dismutase 1)] plays a key role in maintaining the protein's stability and quaternary…”
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Iron–sulfur cluster signaling: The common thread in fungal iron regulation by Gupta, Malini, Outten, Caryn E.

“…Iron homeostasis in fungi involves balancing iron uptake and storage with iron utilization to achieve adequate, nontoxic levels of this essential nutrient…”
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Activation of Cu,Zn-Superoxide Dismutase in the Absence of Oxygen and the Copper Chaperone CCS by Leitch, Jeffry M., Jensen, Laran T., Bouldin, Samantha D., Outten, Caryn E., Hart, P. John, Culotta, Valeria C.

“…Eukaryotic Cu,Zn-superoxide dismutases (SOD1s) are generally thought to acquire the essential copper cofactor and intramolecular disulfide bond through the…”
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Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins by Talib, Evan A., Outten, Caryn E.

“…The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and eukaryotes requires coordination within an expanding network of proteins…”
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Alternative Start Sites in the Saccharomyces cerevisiae GLR1 Gene Are Responsible for Mitochondrial and Cytosolic Isoforms of Glutathione Reductase by Outten, Caryn E., Culotta, Valeria C.

“…To combat oxidative damage, eukaryotic cells have evolved with numerous anti-oxidant factors that are often distributed between cytosolic and mitochondrial…”
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Checks and balances for the iron bank by Outten, Caryn E.

“…The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated by either Fe-S cluster insertion or protein degradation mediated by the E3 ligase…”
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Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae by Outten, Caryn E, Falk, Robert L, Culotta, Valeria C

“…Prolonged exposure to hyperoxia represents a serious danger to cells, yet little is known about the specific cellular factors that affect hyperoxia stress. By…”
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The conserved CDC motif in the yeast iron regulator Aft2 mediates iron–sulfur cluster exchange and protein–protein interactions with Grx3 and Bol2 by Li, Haoran, Outten, Caryn E.

“…The Saccharomyces cerevisiae transcriptional activator Aft1 and its paralog Aft2 respond to iron deficiency by upregulating expression of proteins required for…”
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Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal by Hati, Debolina, Brault, Ariane, Gupta, Malini, Fletcher, Kylie, Jacques, Jean-François, Labbé, Simon, Outten, Caryn E.

“…The Bol2 homolog Fra2 and monothiol glutaredoxin Grx4 together play essential roles in regulating iron homeostasis in Schizosaccharomyces pombe. In vivo…”
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