Search Results - "Ounzain, Samir"

The promise of enhancer-associated long noncoding RNAs in cardiac regeneration by Ounzain, Samir, PhD, Pedrazzini, Thierry, PhD

“…Abstract Heart failure is a worldwide epidemic and represents a major cause of morbidity and mortality. Current clinical therapies for heart disease prolong…”
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CARMEN , a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis by Ounzain, Samir, Micheletti, Rudi, Arnan, Carme, Plaisance, Isabelle, Cecchi, Dario, Schroen, Blanche, Reverter, Ferran, Alexanian, Michael, Gonzales, Christine, Ng, Shi Yan, Bussotti, Giovanni, Pezzuto, Iole, Notredame, Cedric, Heymans, Stephane, Guigó, Roderic, Johnson, Rory, Pedrazzini, Thierry

“…Abstract Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental pathways. However, their roles in human cardiac precursor cell…”
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Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease by Ounzain, Samir, Pezzuto, Iole, Micheletti, Rudi, Burdet, Frédéric, Sheta, Razan, Nemir, Mohamed, Gonzales, Christine, Sarre, Alexandre, Alexanian, Michael, Blow, Matthew J, May, Dalit, Johnson, Rory, Dauvillier, Jérôme, Pennacchio, Len A, Pedrazzini, Thierry

“…Abstract The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of…”
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A transcribed enhancer dictates mesendoderm specification in pluripotency by Alexanian, Michael, Maric, Daniel, Jenkinson, Stephen P., Mina, Marco, Friedman, Clayton E., Ting, Ching-Chia, Micheletti, Rudi, Plaisance, Isabelle, Nemir, Mohamed, Maison, Damien, Kernen, Jasmin, Pezzuto, Iole, Villeneuve, Dominic, Burdet, Frédéric, Ibberson, Mark, Leib, Stephen L., Palpant, Nathan J., Hernandez, Nouria, Ounzain, Samir, Pedrazzini, Thierry

“…Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer…”
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Editorial: RNA-chromatin interactions: Biology, mechanism, disease and therapeutics by Mathiyalagan, Prabhu, Martelotto, Luciano G, Ounzain, Samir, El-Osta, Assam, Uchida, Shizuka

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The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males by Rogala, Sandra, Ali, Tamer, Melissari, Maria-Theodora, Währisch, Sandra, Schuster, Peggy, Sarre, Alexandre, Emídio, Rebeca Cordellini, Boettger, Thomas, Rogg, Eva-Maria, Kaur, Jaskiran, Krishnan, Jaya, Dumbović, Gabrijela, Dimmeler, Stefanie, Ounzain, Samir, Pedrazzini, Thierry, Herrmann, Bernhard G., Grote, Phillip

“…After myocardial infarction in the adult heart the remaining, non-infarcted tissue adapts to compensate the loss of functional tissue. This adaptation requires…”
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Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression by Plaisance, Isabelle, PhD, Perruchoud, Stéphanie, MD, Fernandez-Tenorio, Miguel, PhD, Gonzales, Christine, PhD, Ounzain, Samir, PhD, Ruchat, Patrick, MD, Nemir, Mohamed, PhD, Niggli, Ernst, MD, Pedrazzini, Thierry, PhD

“…Visual Abstract…”
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FIMICS: A panel of long noncoding RNAs for cardiovascular conditions by Firat, Huseyin, Zhang, Lu, Baksi, Shounak, Leszek, Przemyslaw, Schordan, Eric, Ounzain, Samir, Kottwitz, Jan, Patriki, Dimitri, Heidecker, Bettina, Lüscher, Thomas F., Pedrazzini, Thierry, Devaux, Yvan

“…Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve…”
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Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes by Bitsi, Stavroula, Ali, Houda, Maskell, Lauren, Ounzain, Samir, Mohamed-Ali, Vidya, Budhram-Mahadeo, Vishwanie S

“…The POU4F2/Brn-3b transcription factor has been identified as a potentially novel regulator of key metabolic processes. Loss of this protein in Brn-3b knockout…”
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STARS is essential to maintain cardiac development and function in vivo via a SRF pathway by Chong, Nelson W, Koekemoer, Andrea L, Ounzain, Samir, Samani, Nilesh J, Shin, Jordan T, Shaw, Stanley Y

“…STARS (STriated muscle Activator of Rho Signaling) is a sarcomeric protein expressed early in cardiac development that acts as an acute stress sensor for…”
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Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4 by Ounzain, Samir, Kobayashi, Satoru, Peterson, Richard E., He, Aibin, Motterle, Anna, Samani, Nilesh J., Menick, Donald R., Pu, William T., Liang, Qiangrong, Chong, Nelson W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Long Noncoding RNAs in Cardiac Development by Alexanian, Michael, Ounzain, Samir

“…The exquisite transcriptional control of developmental gene programs is critical for hardwiring the complex expression patterns that govern cell-fate…”
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Super-enhancer lncs to cardiovascular development and disease by Ounzain, Samir, Pedrazzini, Thierry

“…Cardiac development, function and pathological remodelling in response to stress depend on the dynamic control of tissue specific gene expression by distant…”
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Targeting and engineering long non-coding RNAs for cancer therapy by Coan, Michela, Haefliger, Simon, Ounzain, Samir, Johnson, Rory

“…RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising…”
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Divergent Paths Lnc Cell Fates by Ounzain, Samir, Pedrazzini, Thierry

“…Long noncoding RNAs (lncRNAs) comprise a class of regulatory molecules that may control diverse stem cell properties. Now in Cell Stem Cell, Luo et al. (2016)…”
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Small and long non-coding RNAs in cardiac homeostasis and regeneration by Ounzain, Samir, Crippa, Stefania, Pedrazzini, Thierry

“…Cardiovascular diseases and in particular heart failure are major causes of morbidity and mortality in the Western world. Recently, the notion of promoting…”
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Discovery and functional characterization of cardiovascular long noncoding RNAs by Ounzain, Samir, Burdet, Frédéric, Ibberson, Mark, Pedrazzini, Thierry

“…Abstract Recent advances in sequencing and genomic technologies have resulted in the discovery of thousands of previously unannotated long noncoding RNAs…”
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The long noncoding RNA Wisper controls cardiac fibrosis and remodeling by Micheletti, Rudi, Plaisance, Isabelle, Abraham, Brian J, Sarre, Alexandre, Ting, Ching-Chia, Alexanian, Michael, Maric, Daniel, Maison, Damien, Nemir, Mohamed, Young, Richard A, Schroen, Blanche, González, Arantxa, Ounzain, Samir, Pedrazzini, Thierry

“…Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these…”
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Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs by Ounzain, Samir, Micheletti, Rudi, Beckmann, Tal, Schroen, Blanche, Alexanian, Michael, Pezzuto, Iole, Crippa, Stefania, Nemir, Mohamed, Sarre, Alexandre, Johnson, Rory, Dauvillier, Jérôme, Burdet, Frédéric, Ibberson, Mark, Guigó, Roderic, Xenarios, Ioannis, Heymans, Stephane, Pedrazzini, Thierry

“…Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are…”
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Long non-coding RNAs in heart failure: a promising future with much to learn by Ounzain, Samir, Pedrazzini, Thierry

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