Search Results - "Oun, Asmaa"

Collagen type I alters the proteomic signature of macrophages in a collagen morphology-dependent manner by Vasse, Gwenda F., Russo, Sara, Barcaru, Andrei, Oun, Asmaa A. A., Dolga, Amalia M., van Rijn, Patrick, Kwiatkowski, Marcel, Govorukhina, Natalia, Bischoff, Rainer, Melgert, Barbro N.

“…Idiopathic pulmonary fibrosis is a progressive lung disease that causes scarring and loss of lung function. Macrophages play a key role in fibrosis, but their…”
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Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity by Sabogal-Guáqueta, Angélica María, Hobbie, Fabian, Keerthi, Akshaya, Oun, Asmaa, Kortholt, Arjan, Boddeke, Erik, Dolga, Amalia

“…[Display omitted] Mitochondrial dysfunction and inflammation contribute to the initiation and development of several brain pathological conditions, including…”
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Protective effect of metformin against palmitate-induced hepatic cell death by Geng, Yana, Hernández Villanueva, Alejandra, Oun, Asmaa, Buist-Homan, Manon, Blokzijl, Hans, Faber, Klaas Nico, Dolga, Amalia, Moshage, Han

“…Lipotoxicity causes hepatic cell death and therefore plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metformin, a…”
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LRRK2 protects immune cells against erastin-induced ferroptosis by Oun, Asmaa, Soliman, Ahmed, Trombetta-Lima, Marina, Tzepapadaki, Afroditi, Tsagkari, Dikaia, Kortholt, Arjan, Dolga, Amalia M.

“…Ferroptosis is an iron-dependent regulated cell death pathway characterized by excessive lipid peroxidation. It is implicated in many neurodegenerative…”
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The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids by Oun, Asmaa, Sabogal-Guaqueta, Angelica Maria, Galuh, Sekar, Alexander, Anastasia, Kortholt, Arjan, Dolga, Amalia M.

“…Parkinson's disease (PD) is the second most common neurodegenerative disease affecting elderly people. Pathogenic mutations in Leucine-Rich Repeat Kinase 2…”
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Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction by Sabogal-Guáqueta, Angélica María, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Oun, Asmaa, Hunneman, Jasmijn, Chen, Tingting, Koistinaho, Jari, Lehtonen, Sarka, Kortholt, Arjan, Wolters, Justina C., Bakker, Barbara M., Eggen, Bart J. L., Boddeke, Erik, Dolga, Amalia

“…Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative…”
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2 by Singh, Ranjan K, Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim

“…Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2…”
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Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages by Oun, Asmaa, Hoeksema, Emmy, Soliman, Ahmed, Brouwer, Famke, García-Reyes, Fabiola, Pots, Henderikus, Trombetta-Lima, Marina, Kortholt, Arjan, Dolga, Amalia M

“…Dysfunction of the immune system and mitochondrial metabolism has been associated with Parkinson's disease (PD) pathology. Mutations and increased kinase…”
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Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors by Aguilar Mora, Fabio Alejandro, Musheshe, Nshunge, Oun, Asmaa, Buist-Homan, Manon, Lezoualc'h, Frank, Cheng, Xiaodong, Schmidt, Martina, Moshage, Han

“…Chronic consumption of the nonsteroidal anti-inflammatory drug diclofenac may induce drug-induced liver injury (DILI). The mechanism of diclofenac-induced…”
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Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity by Musheshe, Nshunge, Oun, Asmaa, Sabogal-Guáqueta, Angélica María, Trombetta-Lima, Marina, Mitchel, Sarah C, Adzemovic, Ahmed, Speek, Oliver, Morra, Francesca, van der Veen, Christina H J T, Lezoualc'h, Frank, Cheng, Xiaodong, Schmidt, Martina, Dolga, Amalia M

“…Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range of cellular functions including oxidative stress and cell survival…”
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Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells by Cattani-Cavalieri, Isabella, Trombetta-Lima, Marina, Yan, Hong, Manzano-Covarrubias, Ana L, Baarsma, Hoeke A, Oun, Asmaa, van der Veen, Melissa Mol, Oosterhout, Emily, Dolga, Amalia M, Ostrom, Rennolds S, Valenca, Samuel Santos, Schmidt, Martina

“…Air pollution from diesel combustion is linked in part to the generation of diesel exhaust particles (DEP). DEP exposure induces various processes, including…”
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THE IMPORTANCE OF MICROGLIA IN METABOLIC CHANGES IN THE BRAIN: A WORLD TO EXPLORE by Sabogal, Angelica, Marmolejo, Alejandro, Lima, Marina Trombetta, Oun, Asmaa, Chen, Tingting, Koistinaho, Jari, Lehtonen, Šarka, Kortholt, Arjan, Bakker, Barbara, Eggen, Bart, Boddeke, Erik, Dolga, Amalia

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A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity by Rosenbusch, Katharina E., Oun, Asmaa, Sanislav, Oana, Lay, Sui T., Keizer-Gunnink, Ineke, Annesley, Sarah J., Fisher, Paul R., Dolga, Amalia M., Kortholt, Arjan

“…Parkinson’s Disease (PD) is the second most common neurodegenerative disease world-wide. Mutations in the multidomain protein Leucine Rich Repeat Kinase 2…”
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The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2) by Konstantinidou, Markella, Oun, Asmaa, Pathak, Pragya, Zhang, Bidong, Wang, Zefeng, ter Brake, Frans, Dolga, Amalia M., Kortholt, Arjan, Dömling, Alexander

“…Here we present the rational design and synthetic methodologies towards proteolysis‐targeting chimeras (PROTACs) for the recently‐emerged target leucine‐rich…”
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Diesel exhaust particles alter cAMP dynamics in human bronchial epithelial cells by Cattani‐Cavalieri, Isabella, Baarsma, Hoeke, Oun, Asmaa, Veen, Melissa, Oosterhout, Emily, Dolga, Amalia, Ostrom, Rennolds, Valença, Samuel, Schmidt, Martina

“…Diesel exhaust particles (DEP) are one of the main causes of air pollution and are associated with lung disorders. DEP exposure may promote several…”
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Linalool attenuates cell death against oxidative stress and mitochondrial dysfunction in neurodegenerative diseases by Guaqueta, Angelica Maria Sabogal, Hobbie, Fabian, Oun, Asmaa, Boddeke, Erik, Gomez, Gloria Patricia Cardona, Dolga, Amalia

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