Scleral lenses for severe chronic GvHD-related keratoconjunctivitis sicca: a retrospective study by the SFGM-TC

Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS....

Full description

Saved in:

Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 52; no. 6; pp. 878 - 882
Main Authors:	Magro, L, Gauthier, J, Richet, M, Robin, M, Nguyen, S, Suarez, F, Dalle, J-H, Fagot, T, Huynh, A, Rubio, M-T, Oumadely, R, Vigouroux, S, Milpied, N, Delcampe, A, Yakoub-Agha, I
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2017 Nature Publishing Group
Subjects:	692/700/565/2194 Acuity Adolescent Adult Aged Allografts Analysis Bone marrow Care and treatment Cell Biology Child Chronic Disease Contact lenses Cornea Dry eye syndromes Female Graft vs Host Disease - pathology Graft vs Host Disease - therapy Graft vs. host disease Graft-versus-host reaction Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Human health and pathology Humans Internal Medicine Keratoconjunctivitis Keratoconjunctivitis Sicca - etiology Keratoconjunctivitis Sicca - pathology Keratoconjunctivitis Sicca - therapy Lens Capsule, Crystalline - pathology Lenses Life Sciences Male Medicine Medicine & Public Health Middle Aged original-article Patients Public Health Quality assessment Quality of Life Retrospective Studies Severity of Illness Index Stem cell transplantation Stem Cells Transplantation Treatment outcome Visual acuity Visual observation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS. In this retrospective, multicenter study, we included 60 consecutive patients diagnosed with cGvHD-related KCS and fitted with scleral lenses. Patients were evaluated at baseline and at 2 months with the following tests: the Ocular Surface Disease Index (OSDI) to assess quality of life, the Oxford score to grade corneal damage and the logarithm of minimal angle of resolution (Log MAR) scale to determine visual acuity. We observed improvement in quality of life in 58 patients (97%). All parameters improved at 2 months. We observed significant differences at 2 months compared with baseline for the mean OSDI (86 versus 30, respectively, P <0.001), the mean Oxford score (3.2 versus 1.3, respectively, P <0.001) as well as visual acuity (Log MAR of 0.33 versus 0.10, respectively, P <0.001). Treatment with scleral lenses was discontinued in only 5 patients (8%) with a median follow-up of 20.5 months (range: 2–125 months). Scleral lenses were very efficient and well tolerated in patients with severe cGvHD-related KCS.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2017.9