Search Results - "Ouisse, Laure‐Hélène"

Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models by Chenouard, Vanessa, Remy, Séverine, Tesson, Laurent, Ménoret, Séverine, Ouisse, Laure-Hélène, Cherifi, Yacine, Anegon, Ignacio

“…The rat has been extensively used as a small animal model. Many genetically engineered rat models have emerged in the last two decades, and the advent of…”
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CD4 + and CD8 + regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model by Ménoret, Séverine, Tesson, Laurent, Remy, Séverine, Gourain, Victor, Sérazin, Céline, Usal, Claire, Guiffes, Aude, Chenouard, Vanessa, Ouisse, Laure-Hélène, Gantier, Malika, Heslan, Jean-Marie, Fourgeux, Cynthia, Poschmann, Jeremie, Guillonneau, Carole, Anegon, Ignacio

“…Regulatory T cells (Treg) in diverse species include CD4 and CD8 T cells. In all species, CD8 Treg have been only partially characterized and there is no rat…”
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Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease by Ossart, Jason, Moreau, Anne, Autrusseau, Elodie, Ménoret, Séverine, Martin, Jérôme C, Besnard, Marine, Ouisse, Laure-Hélène, Tesson, Laurent, Flippe, Léa, Kisand, Kai, Peterson, Pärt, Hubert, François-Xavier, Anegon, Ignacio, Josien, Régis, Guillonneau, Carole

“…Autoimmune regulator (AIRE) deficiency in humans induces a life-threatening generalized autoimmune disease called autoimmune…”
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In Vivo Analysis of Human Immune Responses in Immunodeficient Rats by Ménoret, Séverine, Ouisse, Laure-Hélène, Tesson, Laurent, Remy, Séverine, Usal, Claire, Guiffes, Aude, Chenouard, Vanessa, Royer, Pierre-Joseph, Evanno, Gwenaelle, Vanhove, Bernard, Piaggio, Eliane, Anegon, Ignacio

“…BACKGROUND.Humanized immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune responses in a variety of models,…”
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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies by Clarke, Starlynn C, Ma, Biao, Trinklein, Nathan D, Schellenberger, Ute, Osborn, Michael J, Ouisse, Laure-Hélène, Boudreau, Andrew, Davison, Laura M, Harris, Katherine E, Ugamraj, Harshad S, Balasubramani, Aarti, Dang, Kevin H, Jorgensen, Brett, Ogana, Heather Anne N, Pham, Duy T, Pratap, Payal P, Sankaran, Preethi, Anegon, Ignacio, van Schooten, Wim C, Brüggemann, Marianne, Buelow, Roland, Force Aldred, Shelley

“…Heavy chain-only antibodies (HCAbs) do not associate with light chains and their V regions are functional as single domains, forming the smallest active…”
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Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment by Ouisse, Laure-Hélène, Remy, Séverine, Lafoux, Aude, Larcher, Thibaut, Tesson, Laurent, Chenouard, Vanessa, Guillonneau, Carole, Brusselle, Lucas, Vimond, Nadège, Rouger, Karl, Péréon, Yann, Chenouard, Alexis, Gras-Le Guen, Christèle, Braudeau, Cécile, Josien, Régis, Huchet, Corinne, Anegon, Ignacio

“…Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited…”
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Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models by Ménoret, Séverine, Ouisse, Laure-Hélène, Tesson, Laurent, Delbos, Frédéric, Garnier, Delphine, Remy, Séverine, Usal, Claire, Concordet, Jean-Paul, Giovannangeli, Carine, Chenouard, Vanessa, Brusselle, Lucas, Merieau, Emmanuel, Nerrière-Daguin, Véronique, Duteille, Franck, Bellier-Waast, Frédérique, Fraichard, Alexandre, Nguyen, Tuan H, Anegon, Ignacio

“…BACKGROUNDImmunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune…”
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High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region by Osborn, Michael J, Ma, Biao, Avis, Suzanne, Binnie, Ashleigh, Dilley, Jeanette, Yang, Xi, Lindquist, Kevin, Ménoret, Séverine, Iscache, Anne-Laure, Ouisse, Laure-Hélène, Rajpal, Arvind, Anegon, Ignacio, Neuberger, Michael S, Buelow, Roland, Brüggemann, Marianne

“…Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively…”
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TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity by Ugamraj, Harshad S., Dang, Kevin, Ouisse, Laure-Hélène, Buelow, Benjamin, Chini, Eduardo N., Castello, Giulia, Allison, James, Clarke, Starlynn C, Davison, Laura M., Buelow, Roland, Deng, Rong, Iyer, Suhasini, Schellenberger, Ute, Manika, Sankar N., Bijpuria, Shipra, Musnier, Astrid, Poupon, Anne, Cuturi, Maria Cristina, van Schooten, Wim, Dalvi, Pranjali

“…Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to…”
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Gene targeting in rats using transcription activator-like effector nucleases by Ménoret, Séverine, Tesson, Laurent, Rémy, Séverine, Usal, Claire, Thépenier, Virginie, Thinard, Reynald, Ouisse, Laure-Hélène, De Cian, Anne, Giovannangeli, Carine, Concordet, Jean-Paul, Anegon, Ignacio

“…The rat is a model of choice to understanding gene function and modeling human diseases. Since recent years, successful engineering technologies using…”
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A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals：A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis by Chenouard, Vanessa, Brusselle, Lucas, Heslan, Jean-Marie, Remy, Séverine, Ménoret, Séverine, Usal, Claire, Ouisse, Laure-Hélène, NGuyen, Tuan Huy, Anegon, Ignacio, Tesson, Laurent

“…The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various…”
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Adrenal gland infection by serotype 5 adenovirus requires coagulation factors by Tran, Lucile, Ouisse, Laure-Hélène, Richard-Fiardo, Peggy, Franken, Philippe R, Darcourt, Jacques, Cornilleau, Gaétan, Benihoud, Karim, Vassaux, Georges

“…Recombinant, replication-deficient serotype 5 adenovirus infects the liver upon in vivo, systemic injection in rodents. This infection requires the binding of…”
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Transgenic animals and genetic engineering techniques. Nantes, France, 2–3 July, 2015 by Ménoret, Séverine, Tesson, Laurent, Remy, Séverine, Usal, Claire, Ouisse, Laure-Hélène, Brusselle, Lucas, Chenouard, Vanessa, Nguyen, Tuan H., David, Laurent, Anegon, Ignacio

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Early Treg suppression by a listeriolysin-O-expressing E. coli vaccine in heterologous prime–boost vaccination against cancer by Dai, Ming-Shen, Vassaux, Georges, Xu, Man, You, Ren-In, Hsieh, Yu-Feng, Ouisse, Laure-Hélène, Lo, Kai-Yu, Sytwu, Huey-Kang, Chao, Tsu-Yi

“…Highlights ► Heterologous vaccination against cancer is more immunogenic than homologous. ► Early regulatory T cell suppression is the key to enhanced…”
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A HLA-DQ5 restricted Melan-A/MART-1 epitope presented by melanoma tumor cells to CD4+ T lymphocytes by Larrieu, Pierre, Ouisse, Laure-Hélène, Guilloux, Yannick, Jotereau, Francine, Fonteneau, Jean-François

“…Melan-A/MART1 is a melanocytic differentiation antigen expressed by tumor cells of the majority of melanoma patients and, as such, is considered as a good…”
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Generation of Rag1‐knockout immunodeficient rats and mice using engineered meganucleases by Ménoret, Séverine, Fontanière, Sandra, Jantz, Derek, Tesson, Laurent, Thinard, Reynald, Rémy, Séverine, Usal, Claire, Ouisse, Laure‐Hélène, Fraichard, Alexandre, Anegon, Ignacio

“…Despite the recent availability of gene‐specific nucleases, such as zinc‐finger nucleases (ZFNs) and transcription activator‐like nucleases (TALENs), there is…”
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Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies by Ouisse, Laure-Hélène, Gautreau-Rolland, Laetitia, Devilder, Marie-Claire, Osborn, Michael, Moyon, Melinda, Visentin, Jonathan, Halary, Frank, Bruggemann, Marianne, Buelow, Roland, Anegon, Ignacio, Saulquin, Xavier

“…There is an ever-increasing need of monoclonal antibodies (mAbs) for biomedical applications and fully human binders are particularly desirable due to their…”
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Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regions by Ma, Biao, Osborn, Michael J., Avis, Suzanne, Ouisse, Laure-Hélène, Ménoret, Séverine, Anegon, Ignacio, Buelow, Roland, Brüggemann, Marianne

“…Expression of human antibody repertoires in transgenic animals has been accomplished by introducing large human Ig loci into mice and, more recently, a…”
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Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats by Jung, Chris J., Ménoret, Séverine, Brusselle, Lucas, Tesson, Laurent, Usal, Claire, Chenouard, Vanessa, Remy, Séverine, Ouisse, Laure-Hélène, Poirier, Nicolas, Vanhove, Bernard, de Jong, Pieter J., Anegon, Ignacio

“…BAC transgenic mammalian systems offer an important platform for recapitulating human gene expression and disease modeling. While the larger body mass, and…”
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Advances in transgenic animal models and techniques by Ménoret, Séverine, Tesson, Laurent, Remy, Séverine, Usal, Claire, Ouisse, Laure-Hélène, Brusselle, Lucas, Chenouard, Vanessa, Anegon, Ignacio

“…On May 11th and 12th 2017 was held in Nantes, France, the international meeting “Advances in transgenic animal models and techniques” (…”
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