Search Results - "Ouellette, Marc"

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection by Bigot, Sophia, Leprohon, Philippe, Ouellette, Marc

“…Most of our understanding of folate metabolism in the parasite Leishmania is derived from studies of resistance to the antifolate methotrexate (MTX). A…”
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Growth dynamics of Escherichia coli cells on a surface having AgNbO3 antimicrobial particles by Talebpour, Cyrus, Fani, Fereshteh, Salimnia, Hossein, Ouellette, Marc, Alamdari, Houshang

“…The morphological dynamics of microbial cell proliferation on an antimicrobial surface at an early growth stage was studied with Escherichia coli on the…”
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An Examination of Semantic Performance in Mild Cognitive Impairment Progressors and Nonprogressors by Delage, Emilie, Rouleau, Isabelle, Akzam-Ouellette, Marc-Antoine, Roy-Côté, Frédérique, Joubert, Sven

“…Objective: Mild cognitive impairment (MCI) is a risk factor for developing Alzheimer's disease (AD), and about half of older people with MCI will progress to…”
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Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum by Bhattacharya, Arijit, Leprohon, Philippe, Ouellette, Marc

“…Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are reduced…”
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A boreal wildfire and harvesting database with ensemble confidence attributes for Ontario (1972–2021+) by Remmel, Tarmo K., Ouellette, Marc, Wu, Wesley J.

“…•Boreal wildfires and harvesting sites are mapped annually from 1972 onward.•Disturbances are mapped at point locations to avoid the scaling complexities…”
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Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania by Bhattacharya, Arijit, Leprohon, Philippe, Bigot, Sophia, Padmanabhan, Prasad Kottayil, Mukherjee, Angana, Roy, Gaétan, Gingras, Hélène, Mestdagh, Anais, Papadopoulou, Barbara, Ouellette, Marc

“…Current genome-wide screens allow system-wide study of drug resistance but detecting small nucleotide variants (SNVs) is challenging. Here, we use chemical…”
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Nisin is an effective inhibitor of Clostridium difficile vegetative cells and spore germination by Le Lay, Christophe, Dridi, Larbi, Bergeron, Michel G, Ouellette, Marc, Fliss, Ismaı L

“…Clostridium difficile is the most frequently identified enteric pathogen in patients with nosocomial antibiotic-associated diarrhoea and pseudomembranous…”
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Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania by Ubeda, Jean-Michel, Raymond, Frédéric, Mukherjee, Angana, Plourde, Marie, Gingras, Hélène, Roy, Gaétan, Lapointe, Andréanne, Leprohon, Philippe, Papadopoulou, Barbara, Corbeil, Jacques, Ouellette, Marc

“…Gene amplification of specific loci has been described in all kingdoms of life. In the protozoan parasite Leishmania, the product of amplification is usually…”
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Distinctive features of the oropharyngeal microbiome in Inuit of Nunavik and correlations of mild to moderate bronchial obstruction with dysbiosis by Flahaut, Mathilde, Leprohon, Philippe, Pham, Nguyen Phuong, Gingras, Hélène, Bourbeau, Jean, Papadopoulou, Barbara, Maltais, François, Ouellette, Marc

“…Inuit of Nunavik are coping with living conditions that can influence respiratory health. Our objective was to investigate associations between respiratory…”
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Decreased glutamate transport in acivicin resistant Leishmania tarentolae by Roy, Gaétan, Bhattacharya, Arijit, Leprohon, Philippe, Ouellette, Marc

“…Studies of drug resistance in the protozoan parasites of the genus Leishmania have been helpful in revealing biochemical pathways as potential drug targets…”
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The Game Studies Crisis: What Are the Rules of Play? by Marc Ouellette, Steven Conway

“…Though no field or discipline’s historical vector presents itself as a strictly linear building of knowledge, the historical trajectory of Game Studies is…”
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Holistic understanding of trimethoprim resistance in Streptococcus pneumoniae using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning by Pham, Nguyen-Phuong, Gingras, Hélène, Godin, Chantal, Feng, Jie, Groppi, Alexis, Nikolski, Macha, Leprohon, Philippe, Ouellette, Marc

“…Antimicrobial resistance (AMR) is a public health threat worldwide. Next-generation sequencing (NGS) has opened unprecedented opportunities to accelerate AMR…”
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Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites by Hadighi, Ramtin, Mohebali, Mehdi, Boucher, Patrick, Hajjaran, Homa, Khamesipour, Ali, Ouellette, Marc

“…Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate…”
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CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum by Queffeulou, Marine, Leprohon, Philippe, Fernandez-Prada, Christopher, Ouellette, Marc, Mejía-Jaramillo, Ana María

“…Parasites of the genus pose a global health threat with limited treatment options. New drugs are urgently needed, and genomic screens have the potential to…”
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Simulating dynamic fire regime and vegetation change in a warming Siberia by Williams, Neil G., Lucash, Melissa S., Ouellette, Marc R., Brussel, Thomas, Gustafson, Eric J., Weiss, Shelby A., Sturtevant, Brian R., Schepaschenko, Dmitry G., Shvidenko, Anatoly Z.

“…Background Climate change is expected to increase fire activity across the circumboreal zone, including central Siberia. However, few studies have…”
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Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling by Memari, Babak, Bouttier, Manuella, Dimitrov, Vassil, Ouellette, Marc, Behr, Marcel A, Fritz, Jorg H, White, John H

“…Understanding the mechanisms of host macrophage responses to Mycobacterium tuberculosis is essential for uncovering potential avenues of intervention to boost…”
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Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species by Raymond, Frédéric, Boisvert, Sébastien, Roy, Gaétan, Ritt, Jean-François, Légaré, Danielle, Isnard, Amandine, Stanke, Mario, Olivier, Martin, Tremblay, Michel J., Papadopoulou, Barbara, Ouellette, Marc, Corbeil, Jacques

“…The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an average 16-fold mean coverage by next-generation DNA sequencing technologies…”
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Thiophene derivatives activity against the protozoan parasite Leishmania infantum by Bigot, Sophia, Leprohon, Philippe, Vasquez, Abimael, Bhadoria, Rohit, Skouta, Rachid, Ouellette, Marc

“…Treatments against leishmaniasis are limited and the development of new molecules is crucial. One class of developmental drug that has shown activity against…”
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Comparison of the Wechsler Preschool and Primary Scale of Intelligence-Third Edition and the Leiter-R Intellectual Assessments for Clinic-Referred Children by Renaud, Florence, Béliveau, Marie-Julie, Akzam-Ouellette, Marc-Antoine, Jauvin, Karine, Labelle, Fannie

“…A review of clinical records was conducted for children with developmental, emotional, and behavioral difficulties who were assessed with both the Wechsler…”
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Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms by Fernandez-Prada, Christopher, Vincent, Isabel M, Brotherton, Marie-Christine, Roberts, Mathew, Roy, Gaétan, Rivas, Luis, Leprohon, Philippe, Smith, Terry K, Ouellette, Marc

“…Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short…”
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