Search Results - "Ouellette, André J."

Strain-Specific Polymorphisms in Paneth Cell α-Defensins of C57BL/6 Mice and Evidence of Vestigial Myeloid α-Defensin Pseudogenes by Shanahan, Michael T, Tanabe, Hiroki, Ouellette, André J

“…Paneth cells at the base of small intestinal crypts secrete microbicidal α-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity…”
Get full text

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice by Zhao, Fang, Edwards, Robert, Dizon, Diana, Afrasiabi, Kambiz, Mastroianni, Jennifer R., Geyfman, Mikhail, Ouellette, André J., Andersen, Bogi, Lipkin, Steven M

“…Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that plays important roles in diverse processes in multiple cell lineages as a developmental…”
Get full text

Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species by Basso, Virginia, Garcia, Angie, Tran, Dat Q, Schaal, Justin B, Tran, Patti, Ngole, Diana, Aqeel, Younus, Tongaonkar, Prasad, Ouellette, André J, Selsted, Michael E

“…Systemic candidiasis is a growing health care concern that is becoming even more challenging due to the growing frequency of infections caused by…”
Get full text

CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity by Burkhardt, Amanda M, Tai, Kenneth P, Flores-Guiterrez, Juan P, Vilches-Cisneros, Natalia, Kamdar, Karishma, Barbosa-Quintana, Oralia, Valle-Rios, Ricardo, Hevezi, Peter A, Zuñiga, Joaquin, Selman, Moises, Ouellette, André J, Zlotnik, Albert

“…The mucosal immune network is a crucial barrier preventing pathogens from entering the body. The network of immune cells that mediates the defensive mechanisms…”
Get full text

Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α–converting enzyme by Schaal, Justin B., Maretzky, Thorsten, Tran, Dat Q., Tran, Patti A., Tongaonkar, Prasad, Blobel, Carl P., Ouellette, André J., Selsted, Michael E.

“…Theta-defensins (θ-defensins) are macrocyclic peptides expressed exclusively in granulocytes and selected epithelia of Old World monkeys. They contribute to…”
Get full text

Rhesus macaque θ‐defensin RTD‐1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF‐κB and MAPK pathways by Tongaonkar, Prasad, Trinh, Katie K., Schaal, Justin B., Tran, Dat, Gulko, Percio S., Ouellette, André J., Selsted, Michael E.

“…The anti‐inflammatory effects of θ‐defensin RTD‐1 are mediated by cell signaling pathways that down‐regulate expression of pro‐inflammatory cytokines…”
Get full text

Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms by Basso, Virginia, Tran, Dat Q., Schaal, Justin B., Tran, Patti, Eriguchi, Yoshihiro, Ngole, Diana, Cabebe, Anthony E., Park, A. young, Beringer, Paul M., Ouellette, André J., Selsted, Michael E.

“…Invasive candidiasis is an increasingly frequent cause of serious and often fatal infections in hospitalized and immunosuppressed patients. Mortality rates…”
Get full text

A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1 by Nevins, Amanda M, Subramanian, Akshay, Tapia, Jazma L, Delgado, David P, Tyler, Robert C, Jensen, Davin R, Ouellette, André J, Volkman, Brian F

“…Chemokines make up a superfamily of ∼50 small secreted proteins (8–12 kDa) involved in a host of physiological processes and disease states, with several…”
Get full text

Arginine in α-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior by Schmidt, Nathan W, Tai, Kenneth P, Kamdar, Karishma, Mishra, Abhijit, Lai, Ghee Hwee, Zhao, Kun, Ouellette, André J, Wong, Gerard C L

“…The conserved tridisulfide array of the α-defensin family imposes a common triple-stranded β-sheet topology on peptides that may have highly diverse primary…”
Get full text

Electropositive Charge in α-Defensin Bactericidal Activity: Functional Effects of Lys-for-Arg Substitutions Vary with the Peptide Primary Structure by Llenado, R. Alan, Weeks, Colby S, Cocco, Melanie J, Ouellette, André J

“…Cationic amino acids contribute to α-defensin bactericidal activity. Curiously, although Arg and Lys have equivalent electropositive charges at neutral pH,…”
Get full text

RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts by Tongaonkar, Prasad, Punj, Vasu, Subramanian, Akshay, Tran, Dat Q, Trinh, Katie K, Schaal, Justin B, Laragione, Teresina, Ouellette, André J, Gulko, Percio S, Selsted, Michael E

“…Rhesus theta defensin-1 (RTD-1), a macrocyclic immunomodulatory host defense peptide from Old World monkeys, is therapeutic in pristane-induced arthritis (PIA)…”
Get full text

Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities by Tongaonkar, Prasad, Tran, Patti, Roberts, Kevin, Schaal, Justin, Ösapay, George, Tran, Dat, Ouellette, André J., Selsted, Michael E.

“…θ‐defensins account for a major portion of the antimicrobial activity in macaque neutrophil granules and for the superior activity of macaque preparations…”
Get full text

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice by Canale, Vinicius, Spalinger, Marianne R., Alvarez, Rocio, Sayoc-Becerra, Anica, Sanati, Golshid, Manz, Salomon, Chatterjee, Pritha, Santos, Alina N., Lei, Hillmin, Jahng, Sharon, Chu, Timothy, Shawki, Ali, Hanson, Elaine, Eckmann, Lars, Ouellette, André J., McCole, Declan F.

“…Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for…”
Get full text

High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3 by Tongaonkar, Prasad, Golji, Amir E, Tran, Patti, Ouellette, André J, Selsted, Michael E

“…The azurophilic granules of human neutrophils contain four α-defensins called human neutrophil peptides (HNPs 1-4). HNPs are tridisulfide-linked antimicrobial…”
Get full text

Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS by Zaragoza, Melinda M, Sankaran-Walters, Sumathi, Canfield, Don R, Hung, Jason K S, Martinez, Enrique, Ouellette, André J, Dandekar, Satya

“…Gastrointestinal mucosa is an early target of HIV and a site of viral replication and severe CD4(+) T cell depletion. However, effects of HIV infection on gut…”
Get full text

Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa by Tai, Kenneth P, Kamdar, Karishma, Yamaki, Jason, Le, Valerie V, Tran, Dat, Tran, Patti, Selsted, Michael E, Ouellette, André J, Wong-Beringer, Annie

“…Antibiotic-resistant bacterial pathogens threaten public health. Because many antibiotics target specific bacterial enzymes or reactions, corresponding genes…”
Get more information

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance by Andersson, Håkan S., Figueredo, Sharel M., Haugaard-Kedström, Linda M., Bengtsson, Elina, Daly, Norelle L., Qu, Xiaoqing, Craik, David J., Ouellette, André J., Rosengren, K. Johan

“…Salt-bridge interactions between acidic and basic amino acids contribute to the structural stability of proteins and to protein–protein interactions. A…”
Get full text

Elevated Expression of Paneth Cell CRS4C in Ileitis-prone SAMP1/YitFc Mice: REGIONAL DISTRIBUTION, SUBCELLULAR LOCALIZATION, AND MECHANISM OF ACTION by Shanahan, Michael T, Vidrich, Alda, Shirafuji, Yoshinori, Dubois, Claire L, Henschen-Edman, Agnes, Hagen, Susan J, Cohn, Steven M, Ouellette, André J

“…Paneth cells at the base of small intestinal crypts of Lieberkühn secrete host defense peptides and proteins, including α-defensins, as mediators of innate…”
Get full text

Paneth cells and innate mucosal immunity by Ouellette, André J

“…PURPOSE OF REVIEWRecent evidence shows that disruption of Paneth cell homeostasis by induction of endoplasmic reticulum stress or autophagy, with consequent…”
Get full text

Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization by Schmidt, Nathan W, Mishra, Abhijit, Lai, Ghee Hwee, Davis, Matthew, Sanders, Lori K, Tran, Dat, Garcia, Angie, Tai, Kenneth P, McCray, Paul B, Ouellette, André J, Selsted, Michael E, Wong, Gerard C. L

“…Defensins comprise a potent class of membrane disruptive antimicrobial peptides (AMPs) with well-characterized broad spectrum and selective microbicidal…”
Get full text