Search Results - "Oueis, Emilia"

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics by Oueis, Emilia, Jaspars, Marcel, Westwood, Nicholas J., Naismith, James H.

“…The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are…”
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Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii by Moynié, Lucile, Serra, Ilaria, Scorciapino, Mariano A, Oueis, Emilia, Page, Malcolm Gp, Ceccarelli, Matteo, Naismith, James H

“…New strategies are urgently required to develop antibiotics. The siderophore uptake system has attracted considerable attention, but rational design of…”
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Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates by Ludewig, Hannes, Czekster, Clarissa M, Oueis, Emilia, Munday, Elizabeth S, Arshad, Mohammed, Synowsky, Silvia A, Bent, Andrew F, Naismith, James H

“…Cyclic ribosomally derived peptides possess diverse bioactivities and are currently of major interest in drug development. However, it can be chemically…”
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First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors by Oueis, Emilia, Nachon, Florian, Sabot, Cyrille, Renard, Pierre-Yves

“…The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic…”
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Risk Assessment of Phthalates and Their Metabolites in Hospitalized Patients: A Focus on Di- and Mono-(2-ethylhexyl) Phthalates Exposure from Intravenous Plastic Bags by Saab, Yolande, Oueis, Emilia, Mehanna, Stephanie, Nakad, Zahi, Stephan, Rita, Khnayzer, Rony S.

“…Phthalate esters (PAEs) are plasticizers associated with multiple toxicities; however, no strict regulations have been implemented to restrict their use in…”
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Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization by Oueis, Emilia, Nardone, Brunello, Jaspars, Marcel, Westwood, Nicholas J., Naismith, James H.

“…Natural products comprise a diverse array of molecules, many of which are biologically active. Most natural products are derived from combinations of…”
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Visible‐Light‐Driven Cyclizations by Oueis, Emilia, Elkadi, Mirella, Rios, Ramon

“…In recent years, the interest to develop cyclizations promoted by visible light has been gaining a lot of attention due to its sustainability aspect. In this…”
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Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides by Oueis, Emilia, Klefisch, Thorsten, Zaburannyi, Nestor, Garcia, Ronald, Plaza, Alberto, Müller, Rolf

“…The structures of five linear lipopeptides, thaxteramides A1, A2, B1, B2, and C isolated from the myxobacterium Jahnella thaxteri, were elucidated. They have a…”
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New insights into the kinetic target-guided synthesis of protein ligands by Oueis, Emilia, Sabot, Cyrille, Renard, Pierre-Yves

“…The kinetic target-guided synthesis (KTGS) strategy is an unconventional discovery approach that takes advantage of the presence of the biological target…”
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Persicamidines—Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses by Keller, Lena, Oueis, Emilia, Kaur, Amninder, Safaei, Nasim, Kirsch, Susanne H., Gunesch, Antonia P., Haid, Sibylle, Rand, Ulfert, Čičin‐Šain, Luka, Fu, Chengzhang, Wink, Joachim, Pietschmann, Thomas, Müller, Rolf

“…A new family of highly unusual sesquarterpenoids (persicamidines A–E) exhibiting significant antiviral activity was isolated from a newly discovered…”
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Regio‐ and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives by Hofer, Walter, Oueis, Emilia, Fayad, Antoine Abou, Deschner, Felix, Andreas, Anastasia, Carvalho, Laìs Pessanha, Hüttel, Stephan, Bernecker, Steffen, Pätzold, Linda, Morgenstern, Bernd, Zaburannyi, Nestor, Bischoff, Markus, Stadler, Marc, Held, Jana, Herrmann, Jennifer, Müller, Rolf

“…The rise of antimicrobial resistance poses a severe threat to public health. The natural product chlorotonil was identified as a new antibiotic targeting…”
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Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species by Thongkongkaew, Tawatchai, Ding, Wei, Bratovanov, Evgeni, Oueis, Emilia, Garcı́a-Altares, Marı́a, Zaburannyi, Nestor, Harmrolfs, Kirsten, Zhang, Youming, Scherlach, Kirstin, Müller, Rolf, Hertweck, Christian

“…Bacterial infections of agriculturally important mushrooms and plants pose a major threat to human food sources worldwide. However, structures of chemical…”
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Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles by Sabot, Cyrille, Oueis, Emilia, Brune, Xavier, Renard, Pierre-Yves

“…A general and single-step access to polysubstituted 3-hydroxypyridine scaffolds via hetero-Diels-Alder (HDA) reactions between readily prepared…”
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Derivatisable Cyanobactin Analogues: A Semisynthetic Approach by Oueis, Emilia, Adamson, Catherine, Mann, Greg, Ludewig, Hannes, Redpath, Philip, Migaud, Marie, Westwood, Nicholas J., Naismith, James H.

“…Many natural cyclic peptides have potent and potentially useful biological activities. Their use as therapeutic starting points is often limited by the…”
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Persicamidine – Außergewöhnliche Sesquarterpenoide mit potenter antiviraler Bioaktivität gegen Coronaviren by Keller, Lena, Oueis, Emilia, Kaur, Amninder, Safaei, Nasim, Kirsch, Susanne H., Gunesch, Antonia P., Haid, Sibylle, Rand, Ulfert, Čičin‐Šain, Luka, Fu, Chengzhang, Wink, Joachim, Pietschmann, Thomas, Müller, Rolf

“…Eine neue Substanzfamilie von ungewöhnlichen Sesquarterpenoiden (Persicamidine A–E) mit hoher antiviraler Aktivität wurde aus einem kürzlich entdeckten…”
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Reaction site-driven regioselective synthesis of AChE inhibitors by Oueis, Emilia, Santoni, Gianluca, Ronco, Cyril, Syzgantseva, Olga, Tognetti, Vincent, Joubert, Laurent, Romieu, Anthony, Weik, Martin, Jean, Ludovic, Sabot, Cyrille, Nachon, Florian, Renard, Pierre-Yves

“…The enzyme-directed synthesis is an emerging fragment-based lead discovery approach in which the biological target is able to assemble its own multidentate…”
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Regio‐ und stereoselektive Epoxidierung und saure Epoxidöffnung der antibakteriellen und antiplasmodischen Chlorotonile ergeben hochpotente Derivate by Hofer, Walter, Oueis, Emilia, Fayad, Antoine Abou, Deschner, Felix, Andreas, Anastasia, Carvalho, Laìs Pessanha, Hüttel, Stephan, Bernecker, Steffen, Pätzold, Linda, Morgenstern, Bernd, Zaburannyi, Nestor, Bischoff, Markus, Stadler, Marc, Held, Jana, Herrmann, Jennifer, Müller, Rolf

“…Die Zunahme von antimikrobiellen Resistenzen stellt eine ernsthafte Bedrohung für die öffentliche Gesundheit dar. Der Naturstoff Chlorotonil wurde als neues…”
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Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics by Oueis, Emilia, Jaspars, Marcel, Westwood, Nicholas J., Naismith, James H.

“…The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are…”
Get full text

Regio‐ und stereoselektive Epoxidierung und saure Epoxidöffnung der antibakteriellen und antiplasmodischen Chlorotonile ergeben hochpotente Derivate by Hofer, Walter, Oueis, Emilia, Antoine Abou Fayad, Deschner, Felix, Anastasia, Andreas, Laìs Pessanha de Carvalho, Hüttel, Stephan, Bernecker, Steffen, Pätzold, Linda, Morgenstern, Bernd, Zaburannyi, Nestor, Bischoff, Markus, Stadler, Marc, Held, Jana, Herrmann, Jennifer, Müller, Rolf

“…Die Zunahme von antimikrobiellen Resistenzen stellt eine ernsthafte Bedrohung für die öffentliche Gesundheit dar. Der Naturstoff Chlorotonil wurde als neues…”
Get full text