Magnitude and associated factors of latent tuberculosis infection due to Mycobacterium tuberculosis complex among high-risk groups in urban Bobo-Dioulasso, Burkina Faso

•The overall prevalence of latent tuberculosis infection (LTBI) in this study was 63.36%.•The positivity rate for the tuberculin skin test was higher compared with the QuantiFERON-TB Gold Plus test.•The prevalence of LTBI was high among slaughterhouse workers (100%).•Protozoal infection was found to...

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Published in:	IJID regions Vol. 4; pp. 1 - 9
Main Authors:	Djibougou, Diakourga Arthur, Mensah, Gloria Ivy, Sagna, Tani, Sawadogo, Leon Tinoaga, Ouedraogo, Arsène Kiswensida, Kabore, Antoinette, Hien, Hervé, Meda, Clément Ziemlé, Combary, Adjima, Belem, Adrien Marie-Gaston, Addo, Kennedy Kwasi, Dabiré, Roch Konbobr, Perreau, Matthieu, Zinsstag, Jakob, Diagbouga, Serge Potiandi
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-09-2022 Elsevier
Subjects:	Burkina Faso Interferon-gamma release assay Latent tuberculosis infection Magnitude One Health Original Report TB high-risk groups Tuberculin skin test Burkina Faso TB high-risk groups Tuberculin skin test Interferon-gamma release assay Latent tuberculosis infection Magnitude One Health
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Summary:	•The overall prevalence of latent tuberculosis infection (LTBI) in this study was 63.36%.•The positivity rate for the tuberculin skin test was higher compared with the QuantiFERON-TB Gold Plus test.•The prevalence of LTBI was high among slaughterhouse workers (100%).•Protozoal infection was found to be significantly associated with LTBI. To determine the prevalence and risk factors for latent tuberculosis infection (LTBI) among three high-risk groups – household contacts of TB index cases, healthcare workers and slaughterhouse workers – in Bobo-Dioulasso, Burkina Faso. Participants were recruited to this cross-sectional study from March to July 2020 after giving informed consent. Sociodemographic, clinical and biological data were collected using a structured questionnaire. The QuantiFERON-TB Gold Plus test (QFT-Plus) and the tuberculin skin test (TST) were used for detection of LTBI. Bivariate and multivariate logistic regression analyses were performed to identify risk factors for LTBI. The prevalence of LTBI among 101 participants (age range 15–68 years) was 67.33% [95% confidence interval (CI) 57.27–76.33] and 84.16% (95% CI 75.55–90.66) based on QFT-Plus and TST results, respectively. Compared with healthcare workers and household contacts of TB index cases, the prevalence of LTBI among slaughterhouse workers was significantly higher for both QTF-Plus (96.8%; P<0.001) and TST (100%; P=0.003). Working in a slaughterhouse [adjusted odds ratio (AOR) 1.095, 95% CI 1.00–2.036], smoking (AOR 4.214, 95% CI 1.051–16.899), ≥15 years of exposure (AOR 5.617, 95% CI 1.202–32.198), having an animal at home (AOR 2.735, 95% CI 1.102–6.789) and protozoal infection (AOR 2.591, 95% CI 1.034–6.491) were significantly associated with LTBI on the QFT-Plus assay. The prevalence of LTBI was high in all three groups, particularly slaughterhouse workers. The risk factors identified could form the basis of targeted intervention.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2772-7076 2772-7076
DOI:	10.1016/j.ijregi.2022.05.004