Search Results - "Ouchi, Toru"

The application of Toll like receptors for cancer therapy by So, Eui Young, Ouchi, Toru

“…Toll-like receptor (TLR) proteins play key roles in immune responses against infection. Using TLR proteins, host can recognize the conserved molecular…”
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BRCA1 phosphorylation: Biological consequences by Ouchi, Toru

“…More than a decade has passed since BRCA1, breast cancer tumor suppressor 1, was isolated by reverse genetics in 1994. Its molecular structure and potential…”
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BRCA1 affects global DNA methylation through regulation of DNMT1 by Shukla, Vivek, Coumoul, Xavier, Lahusen, Tyler, Wang, Rui-Hong, Xu, Xiaoling, Vassilopoulos, Athanassios, Xiao, Cuiying, Lee, Mi-Hye, Man, Yan-Gao, Ouchi, Mutsuko, Ouchi, Toru, Deng, Chu-Xia

“…Global DNA hypomethylation at CpG islands coupled with local hypermethylation is a hallmark for breast cancer, yet the mechanism underlying this change remains…”
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A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters by Mahpour, Amin, Scruggs, Benjamin S, Smiraglia, Dominic, Ouchi, Toru, Gelman, Irwin H

“…How TATA-less promoters such as those within CpG islands (CGI) control gene expression is still a subject of active research. Here, we have identified the…”
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Impact of directional coronary atherectomy followed by drug-coated balloon strategy to avoid the complex stenting for bifurcation lesions by Okutsu, Masaaki, Mitomo, Satoru, Ouchi, Toru, Yuki, Hisahito, Ueno, Takahiro, Onish, Hirokazu, Yabushita, Hiroto, Matsuoka, Satoshi, Kawamoto, Hiroyoshi, Watanabe, Yusuke, Tanaka, Kentaro, Naganuma, Toru, Sato, Tomohiko, Tahara, Satoko, Kurita, Naoyuki, Nakamura, Shotaro, Nakamura, Sunao

“…Although the simple single stenting rather than complex double stenting is recommended on percutaneous coronary intervention (PCI) for bifurcation lesions,…”
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Prognostic relevance of B‐type natriuretic peptide in patients with moderate mixed aortic valve disease by Onishi, Hirokazu, Naganuma, Toru, Izumo, Masaki, Ouchi, Toru, Yuki, Haruhito, Mitomo, Satoru, Nakamura, Sunao

“…Aims Data on B‐type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate…”
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Clinical impact of aortic valve replacement in patients with moderate mixed aortic valve disease by Onishi, Hirokazu, Izumo, Masaki, Ouchi, Toru, Yuki, Haruhito, Naganuma, Toru, Nakao, Tatsuya, Nakamura, Sunao

“…Background Information is scarce regarding the clinical implications of aortic valve replacement (AVR) for patients suffering from moderate mixed aortic valve…”
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Physiological and oncogenic Aurora-A pathway by Saeki, Toshiaki, Ouchi, Mutsuko, Ouchi, Toru

“…Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family…”
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STAT1-induced Apoptosis Is Mediated by Caspases 2, 3, and 7 by Sironi, Juan J., Ouchi, Toru

“…STAT1 (signal transducer and activator of transcription 1) has been implicated as a mediator of a variety of biological responses in response to stimulation by…”
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Essential roles of mTOR/Akt pathway in Aurora-A cell transformation by Taga, Makoto, Hirooka, Eiji, Ouchi, Toru

“…We have recently demonstrated that Aurora-A kinase is a potential oncogene to develop mammary gland tumors in mice, when expressed under MMTV promoter. These…”
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BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition by Ouchi, Mutsuko, Fujiuchi, Nobuko, Sasai, Kaori, Katayama, Hiroshi, Minamishima, Yohji A, Ongusaha, Pat P, Deng, Chuxia, Sen, Subrata, Lee, Sam W, Ouchi, Toru

“…Aurora-A/BTAK/STK15 localizes to the centrosome in the G 2 -M phase, and its kinase activity regulates the G 2 to M transition of the cell cycle. Previous…”
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Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors by Shionome, Yoshimi, Yan, Li, Liu, Song, Saeki, Toshiaki, Ouchi, Toru

“…We have previously shown that mammary tumorigenesis in MMTV-Aurora-A mice is further enhanced when p53 is inactivated, demonstrating that integrity of p53…”
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Subsurface velocity structure and site amplification characteristics in Mashiki Town, Kumamoto Prefecture, Japan, inferred from microtremor and aftershock recordings of the 2016 Kumamoto earthquakes by Hayashida, Takumi, Yamada, Masumi, Yamada, Masayuki, Hada, Koji, Mori, Jim, Fujino, Yoshinori, Sakaue, Hiromu, Fukatsu, Sosuke, Nishihara, Eiko, Ouchi, Toru, Fujii, Akio

“…In order to investigate the seismic velocity structure in the region of concentrated severe damage during the 2016 Kumamoto earthquake sequence, we conducted…”
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A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway by AGLIPAY, Jason A, LEE, Sam W, OUCHI, Toru, OKADA, Shinya, FUJIUCHI, Nobuko, OHTSUKA, Takao, KWAK, Jennifer C, YI WANG, JOHNSTONE, Ricky W, CHUXIA DENG, JUN QIN

“…We identified IFI16 as a BRCA1-associated protein involved in p53-mediated apoptosis. IFI16 contains the Pyrin/PAAD/DAPIN domain, commonly found in cell…”
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Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization by Okada, Shinya, Ouchi, Toru

“…Phosphorylation of BRCA1 tumor suppressor protein is regulated during the cell cycle and in response to DNA damage. Several Ser/Thr kinases have been…”
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Long-term Outcome following Percutaneous Intervention of Intra-stent Coronary Occlusion and Evaluating the Different Treatment Modalities by Basavarajaiah, Sandeep, Mitomo, Satoru, Nakamura, Sunao, Sharma, Vinoda, Mohammed, Ishaq, Watanabe, Yusuke, Ouchi, Toru, Bhatia, Gurbir, Ment, Jerome, Athukorala, Sampath, Pitt, Michael, Pulikal, George, Freestone, Bethan, Rides, Hannah, Kumar, Nitin, Watkin, Richard, Lee, Kaeng

“…•Limited data on intra-stent CTO.•We explored the long-term outcomes in patients undergoing PCI to intra-stent CTO.•Acceptable rates of hard endpoints (cardiac…”
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Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase by Chen, Angus, Kleiman, Frida E., Manley, James L., Ouchi, Toru, Pan, Zhen-Qiang

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Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN by Martin, Sarah A, Ouchi, Toru

“…In this study, we show that depletion of Chk1 by small interfering RNA (siRNA) results in failure of reentry to the cell cycle after DNA replication has been…”
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BRCA1–Sp1 interactions in transcriptional regulation of the IGF-IR gene by Abramovitch, Shirley, Glaser, Tova, Ouchi, Toru, Werner, Haim

“…The insulin-like growth factor-I receptor (IGF-IR) plays a critical role in breast tumorigenesis and is overexpressed in most primary tumors. BRCA1 is a…”
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BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis by Martin, Sarah A, Ouchi, Toru

“…Apoptosis is implemented by death machinery that involves the caspase family of proteins, under the condition of a variety of stresses. Previous studies have…”
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