Rapid high-performance liquid chromatographic measurement of amisulpride in human plasma: application to manage acute intoxication

Rapid high-performance liquid chromatographic measurement of amisulpride in human plasma: application to manage acute intoxication

Amisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic and is effective as maintenance therapy in patients with schizophrenia. For toxicological purpose, a rapid RP-HPLC assay was developed for the determination of amisulpride in human plasma. A linear respo...

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Bibliographic Details
Published in:Journal of chromatography. B Vol. 789; no. 1; pp. 101 - 105
Main Authors: Péhourcq, F., Ouariki, S., Bégaud, B.
Format: Journal Article Conference Proceeding
Language:English
Published: Amsterdam Elsevier B.V 05-06-2003
Elsevier Science
Subjects:
Amisulpride
Antipsychotic Agents - blood
Antipsychotic Agents - poisoning
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
Drug intoxications. Doping
Humans
Medical sciences
Pharmacology. Drug treatments
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry, Ultraviolet
Sulpiride - analogs & derivatives
Sulpiride - blood
Sulpiride - poisoning
Amisulpride
Poisoning
Psychosis
Human
Biological fluid
Treatment
HPLC chromatography
Schizophrenia
Benzamide derivatives
Quantitative analysis
Blood plasma
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Summary:Amisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic and is effective as maintenance therapy in patients with schizophrenia. For toxicological purpose, a rapid RP-HPLC assay was developed for the determination of amisulpride in human plasma. A linear response was observed over the concentration range 100–1000 ng/ml. A good accuracy (≤5%) was achieved for all quality controls, with intra- and inter-day variation coefficients equal or inferior to 4.9%. The lower limit of quantification was 20 ng/ml, without interferences of endogenous components. This rapid method (run time <5 min) was used to monitor eight intoxications involving amisulpride.
ISSN:1570-0232
1873-376X
DOI:10.1016/S1570-0232(03)00045-X