Search Results - "Ouangraoua, Aida"
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SimSpliceEvol2: alternative splicing-aware simulation of biological sequence evolution and transcript phylogenies
Published in BMC bioinformatics (11-07-2024)“…SimSpliceEvol is a tool for simulating the evolution of eukaryotic gene sequences that integrates exon-intron structure evolution as well as the evolution of…”
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Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
Published in eLife (30-10-2017)“…Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open-reading frames…”
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Median and small parsimony problems on RNA trees
Published in Bioinformatics (Oxford, England) (28-06-2024)“…Abstract Motivation Noncoding RNAs (ncRNAs) express their functions by adopting molecular structures. Specifically, RNA secondary structures serve as a…”
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SimSpliceEvol: alternative splicing-aware simulation of biological sequence evolution
Published in BMC bioinformatics (17-12-2019)“…It is now well established that eukaryotic coding genes have the ability to produce more than one type of transcript thanks to the mechanisms of alternative…”
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OpenProt 2021: deeper functional annotation of the coding potential of eukaryotic genomes
Published in Nucleic acids research (08-01-2021)“…Abstract OpenProt (www.openprot.org) is the first proteogenomic resource supporting a polycistronic annotation model for eukaryotic genomes. It provides a…”
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Gene tree and species tree reconciliation with endosymbiotic gene transfer
Published in Bioinformatics (Oxford, England) (01-07-2021)“…Abstract Motivation It is largely established that all extant mitochondria originated from a unique endosymbiotic event integrating an α−proteobacterial genome…”
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DoubleRecViz: a web-based tool for visualizing transcript–gene–species tree reconciliation
Published in Bioinformatics (Oxford, England) (27-07-2021)“…Abstract Motivation A phylogenetic tree reconciliation is a mapping of one phylogenetic tree onto another which represents the co-evolution of two sets of taxa…”
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SplicedFamAlign: CDS-to-gene spliced alignment and identification of transcript orthology groups
Published in BMC bioinformatics (29-03-2019)“…The inference of splicing orthology relationships between gene transcripts is a basic step for the prediction of transcripts and the annotation of gene…”
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OpenProt: a more comprehensive guide to explore eukaryotic coding potential and proteomes
Published in Nucleic acids research (08-01-2019)“…Abstract Advances in proteomics and sequencing have highlighted many non-annotated open reading frames (ORFs) in eukaryotic genomes. Genome annotations,…”
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aliFreeFold: an alignment-free approach to predict secondary structure from homologous RNA sequences
Published in Bioinformatics (01-07-2018)“…Abstract Motivation Predicting the conserved secondary structure of homologous ribonucleic acid (RNA) sequences is crucial for understanding RNA functions…”
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Toward a Better Understanding of G4 Evolution in the 3 Living Kingdoms
Published in Evolutionary bioinformatics online (01-01-2023)“…Background: G-quadruplexes (G4s) are secondary structures in DNA and RNA that impact various cellular processes, such as transcription, splicing, and…”
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Reconstructing a SuperGeneTree minimizing reconciliation
Published in BMC bioinformatics (02-10-2015)“…Combining a set of trees on partial datasets into a single tree is a classical method for inferring large phylogenetic trees. Ideally, the combined tree should…”
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OpenProt 2.0 builds a path to the functional characterization of alternative proteins
Published in Nucleic acids research (05-01-2024)“…Abstract The OpenProt proteogenomic resource (https://www.openprot.org/) provides users with a complete and freely accessible set of non-canonical or…”
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Reconstructing the architecture of the ancestral amniote genome
Published in Bioinformatics (01-10-2011)“…MOTIVATION: The ancestor of birds and mammals lived approximately 300 million years ago. Inferring its genome organization is key to understanding the…”
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G-quadruplex occurrence and conservation: more than just a question of guanine–cytosine content
Published in NAR genomics and bioinformatics (01-03-2022)“…Abstract G-quadruplexes are motifs found in DNA and RNA that can fold into tertiary structures. Until now, they have been studied experimentally mainly in…”
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The SCJ Small Parsimony Problem for Weighted Gene Adjacencies
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-07-2019)“…Reconstructing ancestral gene orders in a given phylogeny is a classical problem in comparative genomics. Most existing methods compare conserved features in…”
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Reconstructing protein and gene phylogenies using reconciliation and soft-clustering
Published in Journal of bioinformatics and computational biology (01-12-2017)“…The architecture of eukaryotic coding genes allows the production of several different protein isoforms by genes. Current gene phylogeny reconstruction methods…”
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Gene Tree Construction and Correction Using SuperTree and Reconciliation
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-09-2018)“…The supertree problem asking for a tree displaying a set of consistent input trees has been largely considered for the reconstruction of species trees. Here,…”
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On the identification of conflicting contiguities in ancestral genome reconstruction
Published in Journal of computational biology (01-01-2014)“…In computional biology, up-to-date homology-based methods for the reconstruction of ancestral gene orders usually rely on two phases. First, potential…”
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Reconstructing the Phylogeny of Corynebacteriales while Accounting for Horizontal Gene Transfer
Published in Genome biology and evolution (01-04-2020)“…Abstract Horizontal gene transfer is a common mechanism in Bacteria that has contributed to the genomic content of existing organisms. Traditional methods for…”
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