Search Results - "Ou, Zhanhui"

Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells by Sun, Xiaofang, Ou, Zhanhui, Chen, Ruochan, Niu, Xiaohua, Chen, De, Kang, Rui, Tang, Daolin

“…Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation of lipid reactive oxygen species. However, the…”
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Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system by Song, Bing, Fan, Yong, He, Wenyin, Zhu, Detu, Niu, Xiaohua, Wang, Ding, Ou, Zhanhui, Luo, Min, Sun, Xiaofang

“…The generation of beta-thalassemia (β-Thal) patient-specific induced pluripotent stem cells (iPSCs), subsequent homologous recombination-based gene correction…”
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Cigarette smoking is associated with high level of ferroptosis in seminal plasma and affects semen quality by Ou, Zhanhui, Wen, Qirong, Deng, Yu, Yu, Yang, Chen, Zhiheng, Sun, Ling

“…The effects of cigarette smoking on male semen quality are controversial, and the molecular mechanisms underlying how cigarette smoking affects semen quality…”
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Using affected embryos to establish linkage phase in preimplantation genetic testing for thalassemia by Ou, Zhanhui, Deng, Yu, Liang, Yunhao, Chen, Zhiheng, Sun, Ling

“…This study aimed to evaluate the ability of next-generation sequencing (NGS) to conduct preimplantation genetic testing (PGT) for thalassemia using affected…”
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Day 3 Embryo Morphology is a Significant Predictor of Blastocyst Euploidy by Liang, Yunhao, Ou, Zhanhui, Chen, Zhiheng

“…Background: This retrospective cohort study aims to determine the relationship between morphologic grading of day 1 or 3 embryos and euploid blastocyst rate in…”
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Effects of reduced follicle-stimulating hormone dosage before human chorionic gonadotropin trigger on in vitro fertilization outcomes by Ou, Zhanhui, Du, Jing, Liu, Nengqing, Li, Jieliang, Lin, Xiufeng

“…ObjectiveTo determine whether a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger during ovarian stimulation…”
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Improved Non-Invasive Preimplantation Genetic Testing for Beta-Thalassemia Using Spent Embryo Culture Medium Containing Blastocoelic Fluid by Ou, Zhanhui, Deng, Yu, Liang, Yunhao, Chen, Zhiheng, Sun, Ling

“…To compare successful beta-thalassemia (β-thalassemia) detection rates obtained using spent culture medium and spent culture medium containing blastocoelic…”
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High concordance between next-generation sequencing and single-nucleotide polymorphism array in preimplantation genetic testing for aneuploidy by Ou, Zhanhui, Chen, Zhiheng, Deng, Yu, Sun, Ling

“…Background: This study aimed to compare the use of next-generation sequencing (NGS) and single-nucleotide polymorphism (SNP) array in preimplantation genetic…”
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Does current ovarian endometrioma increase the time for DOR patients to reach live birth in IVF? by Deng, Yu, Ou, Zhanhui, Yin, Minna, Chen, Zhiheng, Chen, Shiling, Sun, Ling

“…The contents of ovarian endometrioma (OMA) such as inflammatory mediators, reactive oxygen species, and iron may disrupt normal folliculogenesis and result in…”
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Feasibility of preimplantation genetic testing for aneuploidy on frozen-thawed embryos following conventional IVF insemination by Wen, Xiaojun, Li, Zhiming, Cheng, Lizi, Huo, Junye, Yu, Wenjuan, Ou, Zhanhui, Liu, Nengqing, Li, Jieliang, Fang, Xiaowu, Lin, Xiufeng

“…Intracytoplasmic sperm injection (ICSI) is commonly employed in preimplantation genetic testing (PGT) to minimize the risk of foreign sperm DNA contamination…”
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The impact of low oocyte maturity ratio on blastocyst euploidy rate: a matched retrospective cohort study by Ou, Zhanhui, Du, Jing, Liu, Nengqing, Fang, Xiaowu, Wen, Xiaojun, Li, Jieliang, Lin, Xiufeng

“…To investigate the association between a low oocyte maturity ratio from in vitro fertilization cycle and blastocyst euploidy. A total of 563 preimplantation…”
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Re-analysis of whole blastocysts after trophectoderm biopsy indicated chromosome aneuploidy by Ou, Zhanhui, Chen, Zhiheng, Yin, Minna, Deng, Yu, Liang, Yunhao, Wang, Wenjun, Yao, Yuanqing, Sun, Ling

“…To compare the concordance between trophectoderm (TE) analysis and whole blastocyst analysis of embryos from chromosomal structural rearrangement (SR)…”
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Case report: Preimplantation genetic testing for X-linked alport syndrome caused by variation in the COL4A5 gene by Liu, Nengqing, Wen, Xiaojun, Ou, Zhanhui, Fang, Xiaowu, Du, Jing, Lin, Xiufeng

“…X-Linked Alport Syndrome (XLAS) is an X-linked, dominant, hereditary nephropathy mainly caused by mutations in the COL4A5 gene, found on chromosome Xq22. In…”
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The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice by Xian, Yexing, Xie, Yingjun, Song, Bing, Ou, Zhanhui, Ouyang, Shuming, Xie, Yuhuan, Yang, Yi, Xiong, Zeyu, Li, Haoxian, Sun, Xiaofang

“…Background β-Thalassaemia is a clinically common cause of hereditary haemolytic anaemia stemming from mutations in important functional regions of the β-globin…”
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Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells by OuYang, Shuming, Sun, Xiaofang, Fan, Di, Song, Bing, He, Wenyin, Xie, Yingjun, Chen, Yuchang, Niu, Xiaohua, Luo, Min, Ou, Zhanhui, Xian, Yexing

“…Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within…”
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Elevated Hemoglobin A2 as a Marker for β-Thalassemia Trait in Pregnant Women by Ou, Zhanhui, Li, Qing, Liu, Weiqiang, Sun, Xiaofang

“…β-thalassemia is one of the most prevalent inherited hemoglobin disorders. Compound heterozygotes or homozygous mutations of the β-globin chain gene account…”
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Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient by Chen, Yuchang, Ou, Zhanhui, Song, Bing, Xian, Yexing, Ouyang, Shuming, Xie, Yuhuan, Xue, Yanting, Sun, Xiaofang

“…47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity…”
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Duchenne Muscular Dystrophy in a Female Patient with a Karyotype of 46,X,i(X)(q10) by Ou, Zhanhui, Li, Shaoying, Li, Qing, Chen, Xiaolin, Liu, Weiqiang, Sun, Xiaofang

“…Duchenne muscular dystrophy (DMD) is a severe recessive X-linked form of muscular dystrophy caused by mutations in the dystrophin gene and it affects males…”
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Combining Single Strand Oligodeoxynucleotides and CRISPR/Cas9 to Correct Gene Mutations in β-Thalassemia-induced Pluripotent Stem Cells by Niu, Xiaohua, He, Wenyin, Song, Bing, Ou, Zhanhui, Fan, Di, Chen, Yuchang, Fan, Yong, Sun, Xiaofang

“…β-Thalassemia (β-Thal) is one of the most common genetic diseases in the world. The generation of patient-specific β-Thal-induced pluripotent stem cells…”
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HSPB1 as a novel regulator of ferroptotic cancer cell death by Sun, X, Ou, Z, Xie, M, Kang, R, Fan, Y, Niu, X, Wang, H, Cao, L, Tang, D

“…Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock…”
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