Search Results - "Ou, Yitao"

Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2 by Lan, Tian, Li, Changzheng, Yang, Guizhi, Sun, Yue, Zhuang, Lihang, Ou, Yitao, Li, Hui, Wang, Genshu, Kisseleva, Tatiana, Brenner, David, Guo, Jiao

“…Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer cells (KCs) leads to liver fibrosis. Here, we aimed to investigate…”
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Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition by Chen, Yinghua, Ou, Yitao, Dong, Jiale, Yang, Guizhi, Zeng, Zhi, Liu, Ying, Liu, Bing, Li, Weidong, He, Xiaoshun, Lan, Tian

“…Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and progression of liver fibrosis. HSCs are believed to be the major source…”
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Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase by Yang, Xiangyu, Lin, Geng, Chen, Yitong, Lei, Xueping, Ou, Yitao, Yan, Yuyun, Wu, Ruiwen, Yang, Jie, Luo, Yiming, Zhao, Lixin, Zhang, Xiuxiu, Yang, Zhongjin, Qin, Aiping, Sun, Ping, Yu, Xi-Yong, Hu, Wenhui

“…Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited treatment options. Thus, it is essential to investigate potential…”
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Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation by Deng, Wenmin, Yang, Zhongjin, Yue, Hu, Ou, Yitao, Hu, Wenhui, Sun, Ping

“…The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a vital role in mediating the innate immune system. Its aberrant activation…”
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Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation by Yue, Hu, Yang, Zhongjin, Ou, Yitao, Liang, Shuli, Deng, Wenmin, Chen, Hao, Zhang, Cheng, Hua, Lei, Hu, Wenhui, Sun, Ping

“…[Display omitted] •15 tanshinones suppressed NLRP3 inflammasome activation.•Tanshinones reduced mitochondrial ROS production and alleviated mitochondrial…”
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Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation by Hao, Ying, Ou, Yitao, Zhang, Cheng, Chen, Hao, Yue, Hu, Yang, Zhongjin, Zhong, Xiaofen, Hu, Wenhui, Sun, Ping

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Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome by Ou, Yitao, Sun, Ping, Wu, Nannan, Chen, Hao, Wu, Dan, Hu, Wenhui, Yang, Zhongjin

“…[Display omitted] Parthenolide (PTL) can target NLRP3 inflammasome to treat inflammation and its related disease, but its cytotoxicity limits further…”
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Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation by Zhou, Yinghua, Yang, Zhongjin, Ou, Yitao, Cai, Haowei, Liu, Zhuorong, Lin, Geng, Liang, Shuli, Hua, Lei, Yan, Yuyun, Zhang, Xiuxiu, Wu, Ruiwen, Qin, Aiping, Hu, Wenhui, Sun, Ping

“…The aberrant activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is known to…”
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Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation by Chen, Xiuhui, Chen, Yanhong, Ou, Yitao, Min, Wenjie, Liang, Shuli, Hua, Lei, Zhou, Yinghua, Zhang, Cheng, Chen, Peifeng, Yang, Zhongjin, Hu, Wenhui, Sun, Ping

“…[Display omitted] The abnormal activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3)…”
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Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities by Zhang, Cheng, Yue, Hu, Sun, Ping, Hua, Lei, Liang, Shuli, Ou, Yitao, Wu, Dan, Wu, Xinyi, Chen, Hao, Hao, Ying, Hu, Wenhui, Yang, Zhongjin

“…NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery…”
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Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis by Hua, Lei, Liang, Shuli, Zhou, Yinghua, Wu, Xinyi, Cai, Haowei, Liu, Zhuorong, Ou, Yitao, Chen, Yanhong, Chen, Xiuhui, Yan, Yuyun, Wu, Dan, Sun, Ping, Hu, Wenhui, Yang, Zhongjin

“…[Display omitted] •Artemisitene significantly inhibits inflammasome-dependent IL-1β release.•Artemisitene can be readily semi-synthesized from…”
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Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway by Ji, Xiaoqian, Li, Changzheng, Ou, Yitao, Li, Ning, Yuan, Kai, Yang, Guizhi, Chen, Xiaoyan, Yang, Zhicheng, Liu, Bing, Cheung, Wai W., Wang, Lijing, Huang, Ren, Lan, Tian

“…Diabetic nephropathy (DN) is characterized by proliferation of mesangial cells, mesangial hypertrophy and extracellular matrix (ECM) accumulation. Our recent…”
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Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity by Wu, Xinyi, Sun, Ping, Chen, Xiuhui, Hua, Lei, Cai, Haowei, Liu, Zhuorong, Zhang, Cheng, Liang, Shuli, Chen, Yanhong, Wu, Dan, Ou, Yitao, Hu, Wenhui, Yang, Zhongjin

“…NLRP3 inflammasome activation plays a critical role in inflammation-related disorders. More small-molecule entities are needed to study the mechanism of NLRP3…”
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Antagonizing interleukin-5 receptor ameliorates dextran sulfate sodium-induced experimental colitis in mice through reducing NLRP3 inflammasome activation by Ou, Yitao, Yang, Zhongjin, Zhou, Yinghua, Yue, Hu, Hua, Lei, Liu, Zhuorong, Lin, Geng, Cai, Haowei, Chen, Yanhong, Hu, Wenhui, Sun, Ping

“…Inflammatory bowel disease (IBD) is a condition characterized by inflammation in the gastrointestinal tract. Reducing intestinal inflammation is a promising…”
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Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice by Liang, Shuli, Yang, Zhongjin, Hua, Lei, Chen, Yanhong, Zhou, Yinghua, Ou, Yitao, Chen, Xiuhui, Yue, Hu, Yang, Xiangyu, Wu, Xinyi, Hu, Wenhui, Sun, Ping

“…The maturation and secretion of interleukin-1β (IL-1β) mediated by NLRP3 inflammasome activation plays an important role in the progression of many…”
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Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice by Chen, Yanhong, Chen, Xiuhui, Liang, Shuli, Ou, Yitao, Lin, Geng, Hua, Lei, Wu, Xinyi, Zhou, Yinghua, Liu, Zhuorong, Cai, Haowei, Yang, Zhongjin, Hu, Wenhui, Sun, Ping

“…Psoriasis is a common chronic autoinflammatory/autoimmune skin disease associated with elevated pro-inflammatory cytokines. The pivotal role of interleukin…”
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Activation of Slit2-Robo1 signaling promotes liver fibrosis by Chang, Jianlan, Lan, Tian, Li, Changzheng, Ji, Xiaoqian, Zheng, Lingyun, Gou, Hongju, Ou, Yitao, Wu, Teng, Qi, Cuiling, Zhang, Qianqian, Li, Jiangchao, Gu, Quliang, Wen, Dingwen, Cao, Liu, Qiao, Liang, Ding, Yanqing, Wang, Lijing

“…Background & Aims The secretory protein Slit2 and its receptor Robo1 are believed to regulate cell growth and migration. Here, we aimed to determine whether…”
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Compound AD110 Acts as Therapeutic Management for Alzheimer’s Disease and Stroke in Mouse and Rat Models by Sun, Ping, Zhou, Wei, Yue, Hu, Zhang, Cheng, Ou, Yitao, Yang, Zhongjin, Hu, Wenhui

“…Anti-inflammatory therapy may be an effective therapeutic intervention for neurological diseases, such as Alzheimer’s disease (AD) and stroke. As an important…”
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Corrigendum to “Osteopontin promotes collagen I synthesis in hepatic stellate cells by miRNA-129-5p inhibition” [Exp. Cell Res. 362(2) (2018) 343–348] by Chen, Yinghua, Ou, Yitao, Dong, Jiale, Yang, Guizhi, Zeng, Zhi, Liu, Ying, Liu, Bing, Li, Weidong, He, Xiaoshun, Lan, Tian

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Compound AD16 Reduces Amyloid Plaque Deposition and Modifies Microglia in a Transgenic Mouse Model of Alzheimer’s Disease by Sun, Ping, Yue, Hu, Xing, Qi, Deng, Wenmin, Ou, Yitao, Pan, Guangjin, Zhong, Xiaofen, Hu, Wenhui

“…Microglial dysfunction is involved in the pathological cascade of Alzheimer’s disease (AD). The regulation of microglial function may be a novel strategy for…”
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