Search Results - "Ou, Kristy"

Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo by Jiang, Yi-Zhou, Jiménez, Juan M, Ou, Kristy, McCormick, Margaret E, Zhang, Ling-Di, Davies, Peter F

“…RATIONALE:Hemodynamic disturbed flow (DF) is associated with susceptibility to atherosclerosis. Endothelial Kruppel-Like Factor 4 (KLF4) is an important…”
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Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation by Mosleh, Elham, Ou, Kristy, Haemmerle, Matthew W, Tembo, Teguru, Yuhas, Andrew, Carboneau, Bethany A, Townsend, Shannon E, Bosma, Karin J, Gannon, Maureen, O’Brien, Richard M, Stoffers, Doris A, Golson, Maria L

“…Abstract Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly…”
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Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function by Ou, Kristy, Hamo, Dania, Schulze, Anne, Roemhild, Andy, Kaiser, Daniel, Gasparoni, Gilles, Salhab, Abdulrahman, Zarrinrad, Ghazaleh, Amini, Leila, Schlickeiser, Stephan, Streitz, Mathias, Walter, Jörn, Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Reinke, Petra, Polansky, Julia K.

“…Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and…”
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Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice by Ou, Kristy, Zhang, Jia, Jiao, Yang, Wang, Zhao V., Scherer, Phillipp, Kaestner, Klaus H.

“…Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore…”
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The Dysregulation of the DLK1 - MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs by Kameswaran, Vasumathi, Golson, Maria L, Ramos-Rodríguez, Mireia, Ou, Kristy, Wang, Yue J, Zhang, Jia, Pasquali, Lorenzo, Kaestner, Klaus H

“…Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing β-cells to overcome insulin resistance. We previously identified an…”
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Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice by Bauer, Robert C, Tohyama, Junichiro, Cui, Jian, Cheng, Lan, Yang, Jifu, Zhang, Xuan, Ou, Kristy, Paschos, Georgios K, Zheng, X Long, Parmacek, Michael S, Rader, Daniel J, Reilly, Muredach P

“…Genome-wide association studies have established ADAMTS7 as a locus for coronary artery disease in humans. However, these studies fail to provide…”
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Targeted demethylation at the CDKN1C/p57 locus induces human β cell replication by Ou, Kristy, Yu, Ming, Moss, Nicholas G, Wang, Yue J, Wang, Amber W, Nguyen, Son C, Jiang, Connie, Feleke, Eseye, Kameswaran, Vasumathi, Joyce, Eric F, Naji, Ali, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H

“…The loss of insulin-secreting β cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of β cells for…”
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The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells by Hochmann, Sarah, Ou, Kristy, Poupardin, Rodolphe, Mittermeir, Michaela, Textor, Martin, Ali, Salaheddine, Wolf, Martin, Ellinghaus, Agnes, Jacobi, Dorit, Elmiger, Juri A J, Donsante, Samantha, Riminucci, Mara, Schäfer, Richard, Kornak, Uwe, Klein, Oliver, Schallmoser, Katharina, Schmidt-Bleek, Katharina, Duda, Georg N, Polansky, Julia K, Geissler, Sven, Strunk, Dirk

“…Multipotent stromal cells are considered attractive sources for cell therapy and tissue engineering. Despite numerous experimental and clinical studies, broad…”
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Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits by Lasconi, Chiara, Pahl, Matthew C, Pippin, James A, Su, Chun, Johnson, Matthew E, Chesi, Alessandra, Boehm, Keith, Manduchi, Elisabetta, Ou, Kristy, Golson, Maria L, Wells, Andrew D, Kaestner, Klaus H, Grant, Struan F A

“…Abstract We investigated the potential role of sleep-trait associated genetic loci in conferring a degree of their effect via pancreatic α- and β-cells, given…”
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Modulating platelet reactivity through control of RGS18 availability by Ma, Peisong, Ou, Kristy, Sinnamon, Andrew J., Jiang, Hong, Siderovski, David P., Brass, Lawrence F.

“…Most platelet agonists activate platelets by binding to G-protein–coupled receptors. We have shown previously that a critical node in the G-protein signaling…”
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Ins1-Cre and [Ins1-Cre.sup.ER] Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation by Mosleh, Elham, Ou, Kristy, Haemmerle, Matthew W, Tembo, Teguru, Yuhas, Andrew, Carboneau, Bethany A, Townsend, Shannon E, Bosma, Karin J, Gannon, Maureen, O'Brien, Richard M, Stoffers, Doris A, Golson, Maria L

“…Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly specific…”
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β Cell Replacement Therapy: A Novel Application for Targeted Epigenetic Editing by Ou, Kristy

“…Pancreatic β cells are the exclusive source of insulin, which normalizes blood glucose levels under hyperglycemic conditions. In 2015, over 252,000 deaths in…”
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Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation by Freitas-Dias, Ricardo, Lima, Tanes I., Costa-Junior, Jose Maria, Gonçalves, Luciana M., Araujo, Hygor N., Paula, Flavia M.M., Santos, Gustavo J., Branco, Renato Chaves Souto, Ou, Kristy, Kaestner, Klaus H., Silveira, Leonardo R., Oliveira, Camila A.M., Boschero, Antonio C., Zoppi, Claudio C., Carneiro, Everardo M.

“…Aim Investigate whether inheritance of improved skeletal muscle mitochondrial function and its association with glycemic control are multigenerational benefits…”
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Targeted demethylation at the CDKN1C/p57 locus induces human cell replication by Ou, Kristy, Yu, Ming, Moss, Nicholas G, Wang, Yue J, Wang, Amber W, Nguyen, Son C, Jiang, Connie, Feleke, Eseye, Kameswaran, Vasumathi, Joyce, Eric F, Naji, Ali, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H

“…The loss of insulin-secreting [beta] cells is characteristic among type I and type II diabetes. Stimulating proliferation to expand sources of [beta] cells for…”
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Abstract 405: Functional Characterization of Coronary Artery Disease (CAD) Associated SNPs at the ADAMTS7 Locus by Ou, Kristy, Nuernberg, Sylvia, Bauer, Robert C, Rader, Daniel J, Reilly, Muredach P

“…Abstract only SNPs in the genomic region containing the gene ADAMTS7, a gene that codes for a metalloproteinase involved in vascular smooth muscle cell…”
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Abstract 267: Identification of Proteolytic Substrates for ADAMTS7 Using Terminal Amine Isotope Labeling of Substrates by Zhang, Xuan, Klein, Theo, Cui, Jian, Ou, Kristy, Hinkle, Christine, Li, Wenjun, Overall, Christopher M, Reilly, Muredach P

“…Abstract only ADAMTS7 , a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, has been recently identified as a novel…”
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Abstract 465: Deciphering the Genetic Regulation of ADAMTS7 , a Novel Locus for Coronary Artery Disease by Ou, Kristy, Bauer, Robert C, Zhang, Xuan, Cui, Jian, Rader, Daniel J, Reilly, Muredach P

“…Abstract only Recent genome-wide association studies (GWAS) have identified an association between the ADAMTS7 locus and coronary artery disease (CAD) in…”
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Abstract 348: TNFα-induced Expression of Adamts7 Affects Primary Mouse Smooth Muscle Cell Migration ex vivo by Bauer, Robert C, Zhang, Xuan, Tohyama, Junichiro, Cui, Jian, Smith, Mikhaila A, Ou, Kristy, Zheng, X. Long, Parmacek, Michael S, Rader, Daniel J, Reilly, Muredach P

“…Abstract only ADAMTS7 has recently been identified as a novel genomic locus associated with coronary artery disease (CAD) in humans. We have recently shown…”
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Abstract 49: Knockout of ADAMTS7, a Novel Human CAD Locus, Reduces Atherosclerosis in Both LDLR and APOE Hyperlipidemic Mouse Models by Bauer, Robert C, Tohyama, Junichiro, Cui, Jian, Zhang, Xuan, Yu, Christopher, Ou, Kristy, Parmacek, Michael S, Rader, Daniel J, Reilly, Muredach P

“…Abstract only Multiple genome-wide association studies demonstrate that the genomic locus containing the gene ADAMTS7 is associated with coronary artery…”
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Knockout of Adamts7, A Novel CAD Locus in Humans, Reduces Atherosclerosis in Mice by Bauer, Robert C., Tohyama, Junichiro, Cui, Jian, Cheng, Lan, Yang, Jifu, Zhang, Xuan, Ou, Kristy, Paschos, Georgios K., Zheng, X. Long, Parmacek, Michael S., Rader, Daniel J., Reilly, Muredach P.

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