Search Results - "Ou, Jianhong"
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trackViewer: a Bioconductor package for interactive and integrative visualization of multi-omics data
Published in Nature methods (01-06-2019)Get full text
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Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
Published in Nature cell biology (01-08-2020)“…Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However, the identity of transitional states and the mechanisms that drive…”
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Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
Published in Nature communications (25-05-2020)“…Nucleoporin proteins (Nups) have been proposed to mediate spatial and temporal chromatin organization during gene regulation. Nevertheless, the molecular…”
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Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis
Published in Nature communications (01-08-2022)“…X chromosome inactivation (XCI) is a dosage compensation phenomenon that occurs in females. Initiation of XCI depends on Xist RNA, which triggers silencing of…”
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The BRAF Oncoprotein Functions through the Transcriptional Repressor MAFG to Mediate the CpG Island Methylator Phenotype
Published in Molecular cell (18-09-2014)“…Most colorectal cancers (CRCs) containing activated BRAF (BRAF[V600E]) have a CpG island methylator phenotype (CIMP) characterized by aberrant hypermethylation…”
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motifStack for the analysis of transcription factor binding site evolution
Published in Nature methods (01-01-2018)Get full text
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ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data
Published in BMC genomics (01-03-2018)“…ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility…”
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Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model
Published in eLife (28-06-2022)“…Mutations in the RNA helicase, , are a leading cause of Intellectual Disability and present as syndrome, a neurodevelopmental disorder associated with cortical…”
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RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis
Published in The Journal of clinical investigation (15-05-2023)“…Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate…”
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TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein
Published in Nature (London) (04-12-2014)“…The RING finger protein TRIM37 is encoded by a gene that is amplified in certain breast cancers, but its function is unknown; here, it is shown to…”
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Electrosynthesis of Organic Compounds from Carbon Dioxide Is Catalyzed by a Diversity of Acetogenic Microorganisms
Published in Applied and Environmental Microbiology (01-05-2011)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity
Published in Developmental cell (07-12-2015)“…Progression from brown preadipocytes to adipocytes engages two transcriptional programs: the expression of adipogenic genes common to both brown fat (BAT) and…”
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Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish
Published in Developmental cell (25-03-2019)“…Attaining proper organ size during development and regeneration hinges on the activity of mitogenic factors. Here, we performed a large-scale chemical screen…”
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VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin
Published in Science signaling (01-05-2018)“…The role of vascular endothelial growth factor (VEGF) signaling in cancer is not only well known in the context of angiogenesis but also important in the…”
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Enhancer selection dictates gene expression responses in remote organs during tissue regeneration
Published in Nature cell biology (01-05-2022)“…Acute trauma stimulates local repair mechanisms but can also impact structures distant from the injury, for example through the activity of circulating…”
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U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3′ End Formation
Published in Molecular cell (19-05-2016)“…Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote…”
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Tead and AP1 Coordinate Transcription and Motility
Published in Cell reports (Cambridge) (09-02-2016)“…The Tead family transcription factors are the major intracellular mediators of the Hippo-Yap pathway. Despite the importance of Hippo signaling in…”
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Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
Published in Nature communications (12-07-2017)“…Browning of subcutaneous white fat (iWAT) involves several reprograming events, but the underlying mechanisms are incompletely understood. Here we show that…”
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miR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Published in eLife (18-02-2014)“…Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF…”
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MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway
Published in Cell reports (Cambridge) (05-12-2017)“…Melanoma accounts for more than 80% of skin cancer-related deaths, and current therapies provide only short-term benefit to patients. Here, we show in melanoma…”
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