Search Results - "Otwinowski, Z."

Crystal Structures of Mitochondrial Processing Peptidase Reveal the Mode for Specific Cleavage of Import Signal Sequences by Taylor, Alexander B., Smith, Barbara S., Kitada, Sakae, Kojima, Katsuhiko, Miyaura, Hideki, Otwinowski, Zbyszek, Ito, Akio, Deisenhofer, Johann

“…Background: Mitochondrial processing peptidase (MPP) is a metalloendopeptidase that cleaves the N-terminal signal sequences of nuclear-encoded proteins…”
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Strategies for macromolecular synchrotron crystallography by Minor, W, Tomchick, DR, Otwinowski, Z

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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA by Luisi, B. F, Xu, W. X, Otwinowski, Z, Freedman, L. P, Yamamoto, K. R, Sigler, P. B

“…Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two…”
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To automate or not to automate: this is the question by Cymborowski, M, Klimecka, M, Chruszcz, M, Zimmerman, M. D, Shumilin, I. A, Borek, D, Lazarski, K, Joachimiak, A, Otwinowski, Z, Anderson, W, Minor, W

“…New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited…”
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Crystal structure of trp represser/operator complex at atomic resolution by Otwinowski, Z, Schevitz, R. W, Zhang, R.-G, Lawson, C. L, Joachimiak, A, Marmorstein, R. Q, Luisi, B. F, Sigler, P. B

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Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site by Walsh, Martin A, Otwinowski, Zbyszek, Perrakis, Anatassis, Anderson, Paul M, Joachimiak, Andrzej

“…Background: Cyanase is an enzyme found in bacteria and plants that catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. In…”
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Using surface-bound rubidium ions for protein phasing by Korolev, S., Dementieva, I., Sanishvili, R., Minor, W., Otwinowski, Z., Joachimiak, A.

“…Rubidium is a monovalent metal that can be used as a counterion in protein solutions. X‐ray anomalous scattering from rubidium ions bound to the protein…”
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The crystal structure of trp aporepressor at 1.8 Å shows how binding tryptophan enhances DNA affinity by Zhang, R.-g, Joachimiak, A, Lawson, C. L, Schevitz, R. W, Otwinowski, Z, Sigler, P. B

“…Comparison of the crystal structure of inactive unliganded trp aporepressor with that of trp repressor shows that binding tryptophan activates the dimer a…”
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Multiparametric scaling of diffraction intensities by Otwinowski, Zbyszek, Borek, Dominika, Majewski, Wladyslaw, Minor, Wladek

“…A novel and general approach to scaling diffraction intensities is presented. The method minimizes the disagreement among multiple measurements of…”
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Processing of X-ray diffraction data collected in oscillation mode by Otwinowski, Z, Minor, W

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From Nonpeptide toward Noncarbon Protease Inhibitors: Metallacarboranes as Specific and Potent Inhibitors of HIV Protease by Petr Cígler, Milan Kožíšek, Pavlína Řezáčová, Jíří Brynda, Otwinowski, Zbyszek, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Lucie Dolečková-Marešová, Martin Máša, Juraj Sedláček, Jochen Bodem, Kräusslich, Hans-Georg, Král, Vladimír, Jan Konvalinka

“…HIV protease (PR) represents a prime target for rational drug design, and protease inhibitors (PI) are powerful antiviral drugs. Most of the current PIs are…”
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Structural genomics: keeping up with expanding knowledge of the protein universe by Grabowski, Marek, Joachimiak, Andrzej, Otwinowski, Zbyszek, Minor, Wladek

“…Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology,…”
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What is the issue with autodeposit? by Otwinowski, Z.

“…Abstract only…”
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Crystal Structure of Soybean Lipoxygenase L-1 at 1.4 Å Resolution by Minor, Wladek, Steczko, Janusz, Stec, Boguslaw, Otwinowski, Zbyszek, Bolin, Jeffrey T, Walter, Rick, Axelrod, Bernard

“…Lipoxygenases, which are widely distributed among plant and animal species, are Fe-containing dioxygenases that act on lipids containing (Z,Z)-pentadiene…”
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Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor by Machius, Mischa, Brautigam, Chad A., Tomchick, Diana R., Ward, Patrick, Otwinowski, Zbyszek, Blevins, Jon S., Deka, Ranjit K., Norgard, Michael V.

“…Tp0655 of Treponema pallidum, the causative agent of syphilis, is predicted to be a 40 kDa membrane lipoprotein. Previous sequence analysis of Tp0655 noted its…”
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The structural genomics experimental pipeline: Insights from global target lists by O'Toole, Nicholas, Grabowski, Marek, Otwinowski, Zbyszek, Minor, Wladek, Cygler, Miroslaw

“…Structural genomics (SG) initiatives are currently attempting to achieve the high‐throughput determination of protein structures on a genome‐wide scale. Here…”
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Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus by Řezáčová, Pavlína, Borek, Dominika, Moy, Shiu F., Joachimiak, Andrzej, Otwinowski, Zbyszek

“…The crystal structure of the Midwest Center for Structural Genomics target APC35832, a 14.7‐kDa cytosolic protein from Bacillus stearothermophilus, has been…”
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Facing up to membranes: structure/function relationships in phospholipases by Achari, A, Scott, D, Barlow, P, Vidal, J C, Otwinowski, Z, Brunie, S, Sigler, P B

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Measurement errors and their consequences in protein crystallography by Borek, Dominika, Minor, Wladek, Otwinowski, Zbyszek

“…This article analyzes the relative impact of various types of measurement uncertainties on different stages of structure determination. The treatment of errors…”
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Hinge-loop mutation can be used to control domain swapping of human cystatin C by Orlikowska, M., Jankowska, E., Behrendt, I., Borek, D., Otwinowski, Z., Skowron, P., Szymańska, A.

“…Abstract only…”
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