Search Results - "Otvos, B."

Sustainable Aldehyde Oxidations in Continuous Flow Using in Situ-Generated Performic Acid by Prieschl, Michael, Ötvös, Sándor B, Kappe, C. Oliver

“…The oxidation of aldehydes is one of the most prevalent methods for the synthesis of a diverse range of carboxylic acids. We herein present a performic acid…”
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Bismuth(III)-Catalyzed Hydration of Terminal Alkynes: Sustainable Synthesis of Methyl Ketones in Batch and Flow by Ötvös, Sándor B, Szécsényi, Zsanett, Fülöp, Ferenc

“…Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth­(III)-catalyzed activation and Markovnikov-type hydration of…”
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Alkyne-Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives by Ötvös, Sándor B., Mándity, István M., Kiss, Lóránd, Fülöp, Ferenc

“…A safe and efficient flow‐chemistry‐based procedure is presented for 1,3‐dipolar cycloaddition reactions between organic azides and acetylenes. This simple and…”
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A layered double hydroxide, a synthetically useful heterogeneous catalyst for azide−alkyne cycloadditions in a continuous-flow reactor by Ötvös, Sándor B., Georgiádes, Ádám, Ádok-Sipiczki, Mónika, Mészáros, Rebeka, Pálinkó, István, Sipos, Pál, Fülöp, Ferenc

“…•Cu(II)Fe(III)-based-layered double hydroxide was prepared and fully characterized.•The as-prepared material was highly active as catalyst in alkyne–azide…”
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Evaluation of the cost of CA-125 measurement, office visit and CT scan in the diagnosis of recurrent ovarian cancer by DeBernardo, R, Knight, J, Otvos, B

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Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut by Ötvös, Sándor B, Llanes, Patricia, Pericàs, Miquel A, Kappe, C Oliver

“…The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of the GABA analogues baclofen, phenibut, and fluorophenibut is…”
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Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition–Oxidative Aldehyde Esterification Sequence Using in Situ-Generated Persulfuric Acid as Oxidant by Nagy, Bence S, Llanes, Patricia, Pericas, Miquel A, Kappe, C. Oliver, Ötvös, Sándor B

“…A novel approach is reported for the enantioselective flow synthesis of rolipram comprising a telescoped asymmetric conjugate addition–oxidative aldehyde…”
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Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis by Ötvös, Sándor B, Pericàs, Miquel A, Kappe, C. Oliver

“…The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant (−)-paroxetine is demonstrated as a continuous flow process on…”
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A Telescoped Continuous Flow Enantioselective Process for Accessing Intermediates of 1‑Aryl-1,3-diols as Chiral Building Blocks by Maestro, Aitor, Nagy, Bence S., Ötvös, Sándor B., Kappe, C. Oliver

“…A telescoped continuous flow process is reported for the enantioselective synthesis of chiral precursors of 1-aryl-1,3-diols, intermediates in the synthesis of…”
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Controlled Transformations of Aryl Halides in a Flow System: Selective Synthesis of Aryl Azides and Aniline Derivatives by Georgiádes, Ádám, Ötvös, Sándor B., Fülöp, Ferenc

“…Copper‐mediated nitrogenation of aryl halides with sodium azide can result in either aryl azides or aniline derivatives. The selectivity of the transformation…”
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Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement by Petrovic, Nikola, Ötvös, Sándor B., Kappe, C. Oliver

“…A high-temperature continuous flow protocol is reported for the intensified synthesis of an important industrial raw material via aromatic Claisen…”
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Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass‐Based Polymeric Additive by Hammer, Susanne, Nanto, Filippo, Canu, Paolo, Ötvös, Sándor B., Kappe, C. Oliver

“…The utilization of water as a sustainable reaction medium has important advantages over traditional organic solvents. Hydroxypropyl methylcellulose has emerged…”
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A High‐Yielding Synthesis of EIDD‐2801 from Uridine by Steiner, Alexander, Znidar, Desiree, Ötvös, Sándor B., Snead, David R., Dallinger, Doris, Kappe, C. Oliver

“…A simple reordering of the reaction sequence allowed the improved synthesis of EIDD‐2801, an antiviral drug with promising activity against the SARS‐CoV‐2…”
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Enantioselective Flow Synthesis of a Tetrahydroquinoline SERM Enabled by Immobilized Chiral Phosphoric Acid Catalysis and Diboronic Acid Mediated Selective Nitro Reduction by Nagy, Bence S., Maestro, Aitor, Chaudhari, Moreshwar B., Kappe, C. Oliver, Ötvös, Sándor B.

“…An asymmetric enantioselective flow process is reported for the formal synthesis of a 1,2,3,4‐tetrahydroquinoline selective estrogen receptor modulator…”
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Continuous‐Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex by Ötvös, Sándor B., Kappe, C. Oliver

“…Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations…”
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Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions by Mandity, István M, Otvos, Sándor B, Szlsi, György, Fulop, Ferenc

“…There is a great need for effective transformations and a broad range of novel chemical entities. Continuous‐flow (CF) approaches are of considerable current…”
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Copper-Loaded Layered Bismuth SubcarbonateEfficient Multifunctional Heterogeneous Catalyst for Concerted C–S/C–N Heterocyclization by Kocsis, Marianna, Ötvös, Sándor B, Samu, Gergely F, Fogarassy, Zsolt, Pécz, Béla, Kukovecz, Ákos, Kónya, Zoltán, Sipos, Pál, Pálinkó, István, Varga, Gábor

“…An efficient self-supported Cu­(II)­Bi­(III) bimetallic catalyst with a layered structure was designed and developed. By careful characterization of the…”
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Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions by Szécsényi, Zsanett, Fülöp, Ferenc, Ötvös, Sándor B.

“…Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne…”
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Continuous-Flow Solid-Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess by Mándity, István M., Olasz, Balázs, Ötvös, Sándor B., Fülöp, Ferenc

“…A highly efficient continuous‐flow technique for the synthesis of peptides was developed. The method allows the application of only 1.5 equivalents of amino…”
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Pharmacokinetics-Driven Evaluation of the Antioxidant Activity of Curcuminoids and Their Major Reduced Metabolites—A Medicinal Chemistry Approach by Girst, Gábor, Ötvös, Sándor B., Fülöp, Ferenc, Balogh, György T., Hunyadi, Attila

“…Curcuminoids are the main bioactive components of the well-known Asian spice and traditional medicine turmeric. Curcuminoids have poor chemical stability and…”
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