Search Results - "Otvös, Ferenc"

Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors by Zádor, Ferenc, Ötvös, Ferenc, Benyhe, Sándor, Zimmer, Andreas, Páldy, Eszter

“…[Display omitted] ► The cannabinoid antagonist rimonabant inhibited μ-opioid receptor (MOR) activation. ► Rimonabant seemed to interact with the antagonist…”
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Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel by Oláh, Zoltán, Jósvay, Katalin, Pecze, László, Letoha, Tamás, Babai, Norbert, Budai, Dénes, Otvös, Ferenc, Szalma, Sándor, Vizler, Csaba

“…Ca(2+)-loaded calmodulin normally inhibits multiple Ca(2+)-channels upon dangerous elevation of intracellular Ca(2+) and protects cells from…”
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Accelerated Molecular Dynamics Applied to the Peptaibol Folding Problem by Tyagi, Chetna, Marik, Tamás, Vágvölgyi, Csaba, Kredics, László, Ötvös, Ferenc

“…The use of enhanced sampling molecular dynamics simulations to facilitate the folding of proteins is a relatively new approach which has quickly gained…”
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Synthesis and biochemical evaluation of 17-N-beta-aminoalkyl-4,5α-epoxynormorphinans by Ötvös, Ferenc, Szűcs, Edina, Urai, Ákos, Köteles, István, Szabó, Pál T., Varga, Zsuzsanna Katalin, Gombos, Dávid, Hosztafi, Sándor, Benyhe, Sándor

“…Opiate alkaloids and their synthetic derivatives are still widely used in pain management, drug addiction, and abuse. To avoid serious side effects, compounds…”
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A round dance of acetaldehyde molecular ensembles on Rh(111) surface; formation and decomposition of various paraldehyde conformers by Kovács, Imre, Ötvös, Ferenc, Farkas, Arnold P., Kiss, János, Kónya, Zoltán

“…•The single molecule itself may have at least two possibilities for adsorption on Rh(111) surfaces, namely η1−(O)−CH3CHOa and η2−(O,C)−CH3CHOa adsorption forms…”
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Tripleurin XIIc: Peptide Folding Dynamics in Aqueous and Hydrophobic Environment Mimic Using Accelerated Molecular Dynamics by Tyagi, Chetna, Marik, Tamás, Szekeres, András, Vágvölgyi, Csaba, Kredics, László, Ötvös, Ferenc

“…Peptaibols are a special class of fungal peptides with an acetylated -terminus and a C-terminal 1,2-amino alcohol along with non-standard amino acid residues…”
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Novel glycosyl prodrug of RXP03 as MMP-11 prodrug: design, synthesis and virtual screening by Abdou, Moaz M., Ötvös, Ferenc, Dong, Dewen, Matziari, Magdalini

“…Like most phosphinic acids, the potent and selective RXP03 inhibitor of different MMPs exhibited moderate absorption and low bioavailability, which impaired…”
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Correction: Tyagi, C., et al. Accelerated Molecular Dynamics Applied to the Peptaibol Folding Problem. International Journal of Molecular Sciences , 2019, 20 , 4268 by Tyagi, Chetna, Marik, Tamás, Vágvölgyi, Csaba, Kredics, László, Ötvös, Ferenc

“…The authors wish to make the following corrections to this paper [...]…”
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Reversible Opening of Intercellular Junctions of Intestinal Epithelial and Brain Endothelial Cells With Tight Junction Modulator Peptides by Bocsik, Alexandra, Walter, Fruzsina R, Gyebrovszki, Andrea, Fülöp, Lívia, Blasig, Ingolf, Dabrowski, Sebastian, Ötvös, Ferenc, Tóth, András, Rákhely, Gábor, Veszelka, Szilvia, Vastag, Monika, Szabó-Révész, Piroska, Deli, Mária A

“…The intercellular junctions restrict the free passage of hydrophilic compounds through the paracellular clefts. Reversible opening of the tight junctions of…”
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Modeling the Effect on a Novel Fungal Peptaibol Placed in an All-Atom Bacterial Membrane Mimicking System via Accelerated Molecular Dynamics Simulations by Tyagi, Chetna, Marik, Tamás, Szekeres, András, Vágvölgyi, Csaba, Kredics, László, Ötvös, Ferenc

“…We previously reported on a novel peptaibol, named Tripleurin XIIc (TPN), an 18-residue long sequence produced by the fungus . We elucidated its 3D structure…”
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Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability by Bocsik, Alexandra, Gróf, Ilona, Kiss, Lóránd, Ötvös, Ferenc, Zsíros, Ottó, Daruka, Lejla, Fülöp, Lívia, Vastag, Monika, Kittel, Ágnes, Imre, Norbert, Martinek, Tamás A, Pál, Csaba, Szabó-Révész, Piroska, Deli, Mária A

“…The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation…”
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Conformational analysis of endomorphin-2 by molecular dynamics methods by Leitgeb, Balázs, Ötvös, Ferenc, Tóth, Géza

“…Endomorphin‐2 (EM2, H–Tyr–Pro–Phe–Phe–NH2) is a highly potent and selective μ‐opioid receptor agonist. A conformational analysis of EM2 was carried out by…”
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Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives by Szűcs, Edina, Marton, János, Szabó, Zoltán, Hosztafi, Sándor, Kékesi, Gabriella, Tuboly, Gábor, Bánki, László, Horváth, Gyöngyi, Szabó, Pál T., Tömböly, Csaba, Varga, Zsuzsanna Katalin, Benyhe, Sándor, Ötvös, Ferenc

“…Morphine and its derivatives play inevitably important role in the μ-opioid receptor (MOR) targeted antinociception. A structure-activity relationship study is…”
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Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data by Winter, Zoltán, Buhala, Andrea, Ötvös, Ferenc, Jósvay, Katalin, Vizler, Csaba, Dombi, György, Szakonyi, Gerda, Oláh, Zoltán

“…This review aims to create an overview of the currently available results of site-directed mutagenesis studies on transient receptor potential vanilloid type 1…”
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Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides by Erdei, Anna I., Borbély, Adina, Magyar, Anna, Szűcs, Edina, Ötvös, Ferenc, Gombos, Dávid, Al-Khrasani, Mahmoud, Stefanucci, Azzurra, Dimmito, Marilisa Pia, Luisi, Grazia, Mollica, Adriano, Benyhe, Sándor

“…•Hybrid peptides are research tools for GPCRs and their interacting complexes.•Nine new ligands were constructed from Dooley peptide RYYRIK and nociceptin…”
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Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions by Erdei, Anna I., Borbély, Adina, Magyar, Anna, Taricska, Nóra, Perczel, András, Zsíros, Ottó, Garab, Győző, Szűcs, Edina, Ötvös, Ferenc, Zádor, Ferenc, Balogh, Mihály, Al-Khrasani, Mahmoud, Benyhe, Sándor

“…•Bivalent ligands are research tools for GPCRs and their interacting complexes.•Three opioid-nociceptin hybrid peptides were studied by biochemical…”
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Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates by Monti, Ludovica, Stefanucci, Azzurra, Pieretti, Stefano, Marzoli, Francesca, Fidanza, Lorenzo, Mollica, Adriano, Mirzaie, Sako, Carradori, Simone, De Petrocellis, Luciano, Schiano Moriello, Aniello, Benyhe, Sándor, Zádor, Ferenc, Szűcs, Edina, Ötvös, Ferenc, Erdei, Anna I, Samavati, Reza, Dvorácskó, Szabolcs, Tömböly, Csaba, Novellino, Ettore

“…Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the…”
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Development of a Chirality-Sensitive Flexibility Descriptor for 3+3D-QSAR by Dervarics, Máté, Ötvös, Ferenc, Martinek, Tamás A

“…Multidimensional QSAR methodologies can be used to predict the active conformation encoded in the conformational preferences of molecules in an active series…”
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Ligand-Based Prediction of Active Conformation by 3D-QSAR Flexibility Descriptors and Their Application in 3+3D-QSAR Models by Martinek, Tamás A, Dervarics, Máté, Tóth, Géza, Fülöp, Ferenc

“…A conceptionally new 3D molecular descriptor type and methodology are deduced by simple statistical thermodynamic reasoning, based on the free energy change…”
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Binding characteristics of [3H]14-methoxymetopon, a high affinity µ-opioid receptor agonist by Spetea, Mariana, Tóth, Fanni, Schütz, Johannes, Ötvös, Ferenc, Tóth, Géza, Benyhe, Sandor, Borsodi, Anna, Schmidhammer, Helmut

“…The highly potent µ‐opioid receptor agonist 14‐methoxymetopon (4,5α‐epoxy‐3‐hydroxy‐14β‐methoxy‐5β,17‐dimethylmorphinan‐6‐one) was prepared in tritium labelled…”
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