Search Results - "Otto, W R"

Side populations of gastrointestinal cancers are not enriched in stem cells by Burkert, J, Otto, WR, Wright, NA

“…The side population (SP) phenotype, defined as the reserpine-blockable ability to efflux the nucleic acid dye Hoechst 33342, has been claimed to be enriched…”
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TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons by Anand, U., Otto, W.R., Facer, P., Zebda, N., Selmer, I., Gunthorpe, M.J., Chessell, I.P., Sinisi, M., Birch, R., Anand, P.

“…TRPA1 is a receptor expressed by sensory neurons, that is activated by low temperature (<17 °C) and plant derivatives such as cinnamaldehyde and isoeugenol, to…”
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Lung epithelial stem cells by Otto, W. R.

“…This review concentrates on recent evidence about lung stem cell origins and plasticity. The range of potential cells which can repopulate the injured lung,…”
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Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage by Otto, W. R., Rao, J.

“…  Stem cells are regenerating medicine. Advances in stem cell biology, and bone marrow‐derived mesenchymal stem cells in particular, are demonstrating that…”
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Circulating mesenchymal stem cells by Roufosse, C.A, Direkze, N.C, Otto, W.R, Wright, N.A

“…Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and…”
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The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons by Anand, U., Otto, W.R., Casula, M.A., Day, N.C., Davis, J.B., Bountra, C., Birch, R., Anand, P.

“…We have studied the effect of key neurotrophic factors (NTFs) on morphology, levels of the vanilloid receptor-1 (TRPV1) and responses to capsaicin in adult…”
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Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential by Valorani, M. G, Germani, A, Otto, W. R, Harper, L, Biddle, A, Khoo, C. P, Lin, W. R, Hawa, M. I, Tropel, P, Patrizi, M. P, Pozzilli, P, Alison, M. R

“…Mesenchymal stem cells (MSCs) are usually cultured under normoxic conditions (21% oxygen). However, in vivo, the physiological “niches” for MSCs have a much…”
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Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice by Bamba, S, Lee, C-Y, Brittan, M, Preston, SL, Direkze, NC, Poulsom, R, Alison, MR, Wright, NA, Otto, WR

“…The authors have previously reported the derivation of colonic subepithelial myofibroblasts (SEMFs) in both humans and mice from bone marrow (BM). In the…”
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Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors by BOETTGER, M. K, TILL, S, BIRCH, R, ANAND, P, CHEN, M. X, ANAND, U, OTTO, W. R, PLUMPTON, C, TREZISE, D. J, TATE, S. N, BOUNTRA, C, COWARD, K

“…Calcium-activated potassium ion channels SK and IK (small and intermediate conductance, respectively) may be important in the pathophysiology of pain following…”
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Allogeneic skin substitutes applied to burns patients by Nanchahal, J., Dover, R., Otto, W.R.

“…Early re-surfacing of burn wounds remains the ideal but is limited by the availability of skin graft donor sites. Cultured grafts overcome these problems and…”
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Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potentials by Valorani, M. G., Montelatici, E., Germani, A., Biddle, A., D'Alessandro, D., Strollo, R., Patrizi, M. P., Lazzari, L., Nye, E., Otto, W. R., Pozzilli, P., Alison, M. R.

“…Objectives Hypoxia is an important factor in many aspects of stem‐cell biology including their viability, proliferation, differentiation and migration. We…”
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In vitro mesenchymal stem cell differentiation after mechanical stimulation by Sarraf, C. E., Otto, W. R., Eastwood, M.

“…Objectives:  Mesenchymal stem cells (MSC) are multipotent cells capable of differentiating into adipocytic, chondrocytic and osteocytic lineages on suitable…”
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Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer by Wright, N.A, Hoffmann, W, Otto, W.R, Rio, M.-C, Thim, L

“…Trefoil factor family (TFF)-domain peptides 1–3 are mucin-associated molecules, largely found in epithelia of gastro-intestinal tissues. Structurally similar,…”
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Recipes for adult stem cell plasticity: fusion cuisine or readymade? by Alison, M R, Poulsom, R, Otto, W R, Vig, P, Brittan, M, Direkze, N C, Lovell, M, Fang, T C, Preston, S L, Wright, N A

“…A large body of evidence supports the idea that certain adult stem cells, particularly those of bone marrow origin, can engraft at alternative locations,…”
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Impact of lanadelumab on health‐related quality of life in patients with hereditary angioedema in the HELP study by Lumry, William R., Weller, Karsten, Magerl, Markus, Banerji, Aleena, Longhurst, Hilary J., Riedl, Marc A., Lewis, Hannah B., Lu, Peng, Devercelli, Giovanna, Jain, Gagan, Maurer, Marcus, Hébert, J, Ritchie, B, Sussman, G, Yang, WH, Martinez‐Saguer, I, Staubach, P, Cicardi, M, Shennak, M, Zaragoza‐Urdaz, RH, Anderson, J, Baptist, AP, Bernstein, JA, Boggs, PB, Busse, PJ, Craig, T, Davis‐Lorton, M, Gierer, S, Gower, RG, Harris, D, Hong, DI, Jacobs, J, Johnston, DT, Li, HH, Lockey, RF, Lugar, P, Manning, ME, McNeil, DL, Melamed, I, Mostofi, T, Nickel, T, Otto, WR, Petrov, AA, Radojicic, C, Rehman, SM, Schwartz, LB, Shapiro, R, Sher, E, Smith, AM, Soteres, D, Tachdjian, R, Wedner, HJ, Weinstein, ME, Zafra, H

“…Background An objective of the phase 3 HELP Study was to investigate the effect of lanadelumab on health‐related quality of life (HRQoL) in patients with…”
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Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks by Riedl, Marc A., Maurer, Marcus, Bernstein, Jonathan A., Banerji, Aleena, Longhurst, Hilary J., Li, H. Henry, Lu, Peng, Hao, James, Juethner, Salomé, Lumry, William R., Hébert, J, Ritchie, B, Sussman, G, Yang, WH, Escuriola Ettingshausen, C, Magerl, M, Martinez‐Saguer, I, Maurer, M, Staubach, P, Zimmer, S, Cicardi, M, Perego, F, Wu, MA, Zanichelli, A, Al‐Ghazawi, A, Shennak, M, Zaragoza‐Urdaz, RH, Ghurye, R, Longhurst, HJ, Zinser, E, Anderson, J, Banerji, A, Baptist, AP, Bernstein, JA, Boggs, PB, Busse, PJ, Christiansen, S, Craig, T, Davis‐Lorton, M, Gierer, S, Gower, RG, Harris, D, Hong, DI, Jacobs, J, Johnston, DT, Levitch, ES, Li, HH, Lockey, RF, Lugar, P, Lumry, WR, Manning, ME, McNeil, DL, Melamed, I, Mostofi, T, Nickel, T, Otto, WR, Petrov, AA, Poarch, K, Radojicic, C, Rehman, SM, Riedl, MA, Schwartz, LB, Shapiro, R, Sher, E, Smith, AM, Smith, TD, Soteres, D, Tachdjian, R, Wedner, HJ, Weinstein, ME, Zafra, H, Zuraw, BL

“…Background Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study. Objective To assess time to onset of…”
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Influence of human skin injury on regeneration of sensory neurons by Taherzadeh, O, Otto, W R, Anand, U, Nanchahal, J, Anand, P

“…The regeneration of sensory nerve fibres is regulated by trophic factors released from their target tissue, particularly the basal epidermis, and matrix…”
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Lung stem cells by OTTO, W.R.

“…The identity of putative stem cells in tracheobronchial, bronchiolar and alveolar compartments is reviewed. Their developmental appearance is described, as is…”
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Trefoil factor family-interacting proteins by Otto, W R, Thim, L

“…Trefoil factor family (TFF) peptides have many in vivo and in vitro effects on restitution, wound healing, apoptosis, cell motility, adhesion and vectorial ion…”
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Trefoil factor family (TFF)-domain peptides in the mouse: embryonic gastrointestinal expression and wounding response by Otto, W R, Patel, K

“…Trefoil factor family (TFF)-domain peptides are mucin-associated molecules that play a role in maintaining gastrointestinal (GI) epithelial integrity. They are…”
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