Search Results - "Otto, Sigrid A."

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans by den Braber, Ineke, Mugwagwa, Tendai, Vrisekoop, Nienke, Westera, Liset, Mögling, Ramona, Bregje de Boer, Anne, Willems, Neeltje, Schrijver, Elise H.R., Spierenburg, Gerrit, Gaiser, Koos, Mul, Erik, Otto, Sigrid A., Ruiter, An F.C., Ackermans, Mariette T., Miedema, Frank, Borghans, José A.M., de Boer, Rob J., Tesselaar, Kiki

“…Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an…”
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Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT by Baliu-Piqué, Mariona, van Hoeven, Vera, Drylewicz, Julia, van der Wagen, Lotte E, Janssen, Anke, Otto, Sigrid A, van Zelm, Menno C, de Boer, Rob J, Kuball, Jürgen, Borghans, Jose Am, Tesselaar, Kiki

“…Lymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and lifespan increase homeostatically when lymphocyte…”
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Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial by van Lelyveld, Steven F L, Drylewicz, Julia, Krikke, Maaike, Veel, Ellen M, Otto, Sigrid A, Richter, Clemens, Soetekouw, Robin, Prins, Jan M, Brinkman, Kees, Mulder, Jan Willem, Kroon, Frank, Middel, Ananja, Symons, Jori, Wensing, Annemarie M J, Nijhuis, Monique, Borghans, José A M, Tesselaar, Kiki, Hoepelman, Andy I M

“…The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of…”
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Low Immune Activation despite High Levels of Pathogenic Human Immunodeficiency Virus Type 1 Results in Long-Term Asymptomatic Disease by CHOUDHARY, Shailesh K, VRISEKOOP, Nienke, JANSEN, Christine A, OTTO, Sigrid A, SCHUITEMAKER, Hanneke, MIEDEMA, Frank, CAMERMI, David

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection by Drylewicz, Julia, Vrisekoop, Nienke, Mugwagwa, Tendai, de Boer, Anne Bregje, Otto, Sigrid A, Hazenberg, Mette D, Tesselaar, Kiki, de Boer, Rob J, Borghans, José A M

“…Naive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have…”
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Turnover of Murine Cytomegalovirus-Expanded CD8 + T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response by Baliu-Piqué, Mariona, Drylewicz, Julia, Zheng, Xiaoyan, Borkner, Lisa, Swain, Arpit C, Otto, Sigrid A, de Boer, Rob J, Tesselaar, Kiki, Cicin-Sain, Luka, Borghans, José A M

“…The potential of memory T cells to provide protection against reinfection is beyond question. Yet, it remains debated whether long-term T cell memory is due to…”
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Evidence that human CD8+CD45RA+CD27– cells are induced by antigen and evolve through extensive rounds of division by Hamann, Dörte, Kostense, Stefan, Wolthers, Katja C., Otto, Sigrid A., Baars, Paul A., Miedema, Frank, van Lier, René A. W.

“…We recently showed that circulating human CD8+ effector cells have a CD45RA+CD27– membrane phenotype. In itself this phenotype appeared to pose a paradox:…”
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Quantification of T-cell dynamics during latent cytomegalovirus infection in humans by van den Berg, Sara P H, Derksen, Lyanne Y, Drylewicz, Julia, Nanlohy, Nening M, Beckers, Lisa, Lanfermeijer, Josien, Gessel, Stephanie N, Vos, Martijn, Otto, Sigrid A, de Boer, Rob J, Tesselaar, Kiki, Borghans, José A M, van Baarle, Debbie

“…Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to be associated with ageing of the immune system. The effect on the…”
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In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow by Baliu-Piqué, Mariona, Otto, Sigrid A., Borghans, José A.M., Tesselaar, Kiki

“…[Display omitted] •CD4+ and CD8+ memory T-cells from bone marrow, spleen and lymph nodes have similar turnover rates.•Memory T-cells are continuously…”
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Persistent immune activation in HIV-1 infection is associated with progression to AIDS by HAZENBERG, Mette D, OTTO, Sigrid A, VAN BENTHEM, Birgit H. B, ROOS, Marijke Th. L, COUTINHO, Roel A, LANGE, Joep M. A, HAMANN, Dörte, PRINS, Maria, MIEDEMA, Frank

“…HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood. To study the…”
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Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome by Bloemers, Beatrijs L P, Bont, Louis, de Weger, Roel A, Otto, Sigrid A, Borghans, Jose A, Tesselaar, Kiki

“…Children with Down syndrome (DS) have low numbers of naive T cells and abnormal thymus development and function. Because next to thymic production, peripheral…”
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Quantification of naive and memory T-cell turnover during HIV-1 infection by Vrisekoop, Nienke, Drylewicz, Julia, Van Gent, Rogier, Mugwagwa, Tendai, Van Lelyveld, Steven F L, Veel, Ellen, Otto, Sigrid A, Ackermans, Mariëtte T, Vermeulen, Joost N, Huidekoper, Hidde H, Prins, Jan M, Miedema, Frank, de Boer, Rob J, Tesselaar, Kiki, Borghans, José A M

“…In HIV infection, the homeostasis of CD4 and CD8 T cells is dramatically disturbed, and several studies have pointed out that T-cell turnover rates are…”
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Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration? by van Gent, Rogier, Schadenberg, Alvin W.L., Otto, Sigrid A., Nievelstein, Rutger A.J., Sieswerda, Gertjan T., Haas, Felix, Miedema, Frank, Tesselaar, Kiki, Jansen, Nicolaas J.G., Borghans, José A.M.

“…Thymectomy during early childhood is generally thought to have serious consequences for the establishment of the T-cell compartment. In the present study, we…”
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Low-Level CD4+ T Cell Activation Is Associated with Low Susceptibility to HIV-1 Infection by Koning, Fransje A, Otto, Sigrid A, Hazenberg, Mette D, Dekker, Linda, Prins, Maria, Miedema, Frank, Schuitemaker, Hanneke

“…Different features have been associated with low susceptibility to HIV type 1 (HIV-1) infection in exposed seronegative individuals. These include genetic…”
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Immune reconstitution in children following chemotherapy for haematological malignancies: a long‐term follow‐up by van Tilburg, Cornelis M., van Gent, Rogier, Bierings, Marc B., Otto, Sigrid A., Sanders, Elisabeth A. M., Nibbelke, Elisabeth E., Gaiser, Jacobus F., Janssens‐Korpela, Pirkko L., Wolfs, Tom F. W., Bloem, Andries C., Borghans, José A. M., Tesselaar, Kiki

“…Summary Modern intensive chemotherapy for childhood haematological malignancies has led to high cure rates, but has detrimental effects on the immune system…”
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Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency by Borghans, José A., Bredius, Robbert G., Hazenberg, Mette D., Roelofs, Helene, Jol-van der Zijde, Els C., Heidt, Jeroen, Otto, Sigrid A., Kuijpers, Taco W., Fibbe, Willem E., Vossen, Jaak M., Miedema, Frank, van Tol, Maarten J.

“…The immune system of patients with severe combined immunodeficiency (SCID) reconstitutes to a large extent during the first years after hematopoietic stem cell…”
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Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection by Miedema, Frank, Hazenberg, Mette D, Otto, Sigrid A, Stuart, James W.T. Cohen, Verschuren, Martie C.M, Borleffs, Jan C.C, Boucher, Charles A.B, Coutinho, Roel A, Lange, Joep M.A, de Wit, Tobias F. Rinke, Tsegaye, Aster, van Dongen, Jacques J.M, Hamann, Dörte, de Boer, Rob J

“…Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs…”
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Restoration of the CD4 T Cell Compartment after Long-Term Highly Active Antiretroviral Therapy without Phenotypical Signs of Accelerated Immunological Aging by Vrisekoop, Nienke, van Gent, Rogier, de Boer, Anne Bregje, Otto, Sigrid A, Borleffs, Jan C. C, Steingrover, Radjin, Prins, Jan M, Kuijpers, Taco W, Wolfs, Tom F. W, Geelen, Sibyl P. M, Vulto, Irma, Lansdorp, Peter, Tesselaar, Kiki, Borghans, Jose A. M, Miedema, Frank

“…It remains uncertain whether full T cell reconstitution can be established in HIV-infected children and adults with long-term sustained virological control by…”
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T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events by Hazenberg, Mette D., Otto, Sigrid A., de Pauw, Elmar S., Roelofs, Helene, Fibbe, Willem E., Hamann, Dörte, Miedema, Frank

“…It is generally believed that homeostatic responses regulate T-cell recovery after peripheral stem cell transplantation (PSCT). We studied in detail immune…”
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In vivo Dynamics of Stable Chronic Lymphocytic Leukemia Inversely Correlate with Somatic Hypermutation Levels and Suggest No Major Leukemic Turnover in Bone Marrow by VAN GENT, Rogier, KATER, Arnon P, VAN OERS, Marinus H. J, TESSELAAR, Kiki, KERSTEN, Marie José, MIEDEMA, Frank, OTTO, Sigrid A, JASPERS, A, BORGHANS, José A. M, VRISEKOOP, Nienke, ACKERMANS, Mariëtte A. T, RUITER, An F. C, WITTEBOL, Shulamiet, ELDERING, Eric

“…Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this…”
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