Search Results - "Otto, Keith A."

Structural basis for GPR40 allosteric agonism and incretin stimulation by Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq

“…Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of…”
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Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis by Cao, Guoqing, Liang, Yu, Broderick, Carol L., Oldham, Brian A., Beyer, Thomas P., Schmidt, Robert J., Zhang, Youyan, Stayrook, Keith R., Suen, Chen, Otto, Keith A., Miller, Anne R., Dai, Jiannong, Foxworthy, Patricia, Gao, Hong, Ryan, Timothy P., Jiang, Xian-Cheng, Burris, Thomas P., Eacho, Patrick I., Etgen, Garret J.

“…The oxysterol receptors LXR (liver X receptor)-α and LXRβ are nuclear receptors that play a key role in regulation of cholesterol and fatty acid metabolism. We…”
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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) by Hamdouchi, Chafiq, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, Eessalu, Thomas E, Ficorilli, James V, Marcelo, Marialuisa C, Otto, Keith A, Wilbur, Kelly L, Lineswala, Jayana P, Piper, Jared L, Coffey, D. Scott, Sweetana, Stephanie A, Haas, Joseph V, Brooks, Dawn A, Pratt, Edward J, Belin, Ruth M, Deeg, Mark A, Ma, Xiaosu, Cannady, Ellen A, Johnson, Jason T, Yumibe, Nathan P, Chen, Qi, Maiti, Pranab, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Reifel Miller, Anne

“…The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to…”
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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus by Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M, DeBaillie, Amy C, Otto, Keith A, Wilbur, Kelly L, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P, Neathery, Grace L, Bouaichi, Cecilia, Diseroad, Benjamin A, Campbell, Alison N, Sweetana, Stephanie A, Adams, Lisa A, Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel

“…As a part of our program to identify potent GPR40 agonists capable of being dosed orally once daily in humans, we incorporated fused heterocycles into our…”
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Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes by Liu, Yanfang, Michael, M. Dodson, Kash, Shera, Bensch, William R, Monia, Brett P, Murray, Susan F, Otto, Keith A, Syed, Samreen K, Bhanot, Sanjay, Sloop, Kyle W, Sullivan, John M, Reifel-Miller, Anne

“…Adiponectin/adiponectin receptors (AdipoR) are involved in energy homeostasis and inflammatory pathways. To investigate the role of AdipoR2 in metabolic…”
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Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARγ signaling by Moyers, Julie S., Shiyanova, Tatiyana L., Mehrbod, Farrokh, Dunbar, James D., Noblitt, Timothy W., Otto, Keith A., Reifel-Miller, Anne, Kharitonenkov, Alexei

“…Fibroblast growth factor (FGF)‐21 is a novel regulator of insulin‐independent glucose transport in 3T3‐L1 adipocytes and has glucose and triglyceride lowering…”
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Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling by Moyers, Julie S, Shiyanova, Tatiyana L, Mehrbod, Farrokh, Dunbar, James D, Noblitt, Timothy W, Otto, Keith A, Reifel-Miller, Anne, Kharitonenkov, Alexei

“…Fibroblast growth factor (FGF)-21 is a novel regulator of insulin-independent glucose transport in 3T3-L1 adipocytes and has glucose and triglyceride lowering…”
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