Search Results - "Otto, Daniel P"

Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly by de Villiers, Melgardt M., Otto, Daniel P., Strydom, Schalk J., Lvov, Yuri M.

“…Studies on the adsorption of oppositely charged colloidal particles ultimately resulted in multilayered polyelectrolyte self-assembly. The inception of…”
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Layer-By-Layer Nanocoating of Antiviral Polysaccharides on Surfaces to Prevent Coronavirus Infections by Otto, Daniel P, de Villiers, Melgardt M

“…In 2020, the world is being ravaged by the coronavirus, SARS-CoV-2, which causes a severe respiratory disease, Covid-19. Hundreds of thousands of people have…”
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In Vitro Skin Delivery of Griseofulvin by Layer-by-Layer Nanocoated Emulsions Stabilized by Whey Protein and Polysaccharides by Otto, Daniel P, Otto, Anja, de Villiers, Melgardt M

“…Griseofulvin is a poorly water-soluble drug administered orally to treat topical fungal infections of the skin and hair. However, oral administration leads to…”
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Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity by Strydom, Schalk J., MSc, Rose, Warren E., PharmD, Otto, Daniel P., PhD, Liebenberg, Wilna, DSc, de Villiers, Melgardt M., PhD

“…Abstract Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM)…”
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Solid State Concerns During Drug Discovery and Development: Thermodynamic and Kinetic Aspects of Crystal Polymorphism and the Special Cases of Concomitant Polymorphs, Co-Crystals and Glasses by Otto, Daniel P, De Villiers, Melgardt M

“…During drug discovery and development the thermodynamics and kinetics of crystal form transitions must be studied and the fundamental properties of polymorphs…”
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Dissipative Particle Dynamics Investigation of the Transport of Salicylic Acid through a Simulated In Vitro Skin Permeation Model by Otto, Daniel P, Combrinck, Johann, Otto, Anja, Tiedt, Louwrens R, de Villiers, Melgardt M

“…Permeation models are often used to determine diffusion properties of a drug through a membrane as it is released from a delivery system. In order to…”
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Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies by Wallis, Lonette, Malan, Maides, Gouws, Chrisna, Steyn, Dewald, Ellis, Suria, Abay, Efrem, Wiesner, Lubbe, Otto, Daniel P, Hamman, Josias

“…Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed…”
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Application of halloysite clay nanotubes as a pharmaceutical excipient by Yendluri, Raghuvara, Otto, Daniel P., De Villiers, Melgardt M., Vinokurov, Vladimir, Lvov, Yuri M.

“…[Display omitted] Halloysite nanotubes, a biocompatible nanomaterial of 50–60nm diameter and ca. 15nm lumen, can be used for loading, storage and sustained…”
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Poly(amidoamine) Dendrimers as a Pharmaceutical Excipient. Are We There yet? by Otto, Daniel P, de Villiers, Melgardt M

“…Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can…”
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All-atomistic molecular dynamics (AA-MD) studies and pharmacokinetic performance of PAMAM-dendrimer-furosemide delivery systems by Otto, Daniel P., de Villiers, Melgardt M.

“…[Display omitted] Improvement of problematic dissolution and solubility properties of a model drug, furosemide, was investigated for poly(amidoamine) (PAMAM)…”
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Coarse-Grained Molecular Dynamics (CG-MD) Simulation of the Encapsulation of Dexamethasone in PSS/PDDA Layer-by-Layer Assembled Polyelectrolyte Nanocapsules by Otto, Daniel P., de Villiers, Melgardt M.

“…Experimental studies have reported the fundamental and applied science aspects of polyelectrolyte (PE) layer-by-layer (LbL) self-assembly. LbL nanocoating is a…”
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Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery by Otto, Daniel P, Otto, Anja, de Villiers, Melgardt M

“…The increase in the development of novel nanoparticle drug delivery systems makes the choice between micro- and nanoscale drug delivery systems ubiquitous…”
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Experimental and mesoscale computational dynamics studies of the relationship between solubility and release of quercetin from PEG solid dispersions by Otto, Daniel P., Otto, Anja, de Villiers, Melgardt M.

“…The flavonol quercetin is potentially clinically relevant for its antimicrobial, beneficial cardiovascular effects, cancer treatment amongst others. However,…”
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Aluminum triflate-cocatalyzed radical copolymerization of styrene and ethyl acrylate by Guyo, Upenyu, Otto, Daniel P., Young, Desmond A., Vosloo, Hermanus C. M.

“…Various random copolymers, poly(styrene- co -ethyl acrylate), were synthesized by free radical bulk copolymerization cocatalyzed by aluminum triflate (Al(OTf)…”
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Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes by Devarakonda, Bharathi, Otto, Daniel P., Judefeind, Anja, Hill, Ronald A., de Villiers, Melgardt M.

“…The complexation of the practically insoluble drug furosemide (acidic p K a 3.22) with lower generation PAMAM dendrimers showed a significant release…”
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Prevention of Biofilm Formation by Methacrylate-Based Copolymer Films Loaded With Rifampin, Clarithromycin, Doxycycline Alone or in Combination by Rose, Warren E., Otto, Daniel P., Aucamp, Marique E., Miller, Zach, de Villiers, Melgardt M.

“…Purpose This study reports the incorporation of the antibiotics rifampin, doxycycline and clarithromycin in poly(styrene- co -methyl methacrylate films and…”
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What is the future of heated transdermal delivery systems? by Otto, Daniel P, de Villiers, Melgardt M

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Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles by Strydom, Schalk J., Otto, Daniel P., Stieger, Nicole, Aucamp, Marique E., Liebenberg, Wilna, de Villiers, Melgardt M.

“…A layer-by-layer (LbL) nanocoat (<25nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles…”
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The Experimental Evaluation and Molecular Dynamics Simulation of a Heat-Enhanced Transdermal Delivery System by Otto, Daniel P., de Villiers, Melgardt M.

“…Transdermal delivery systems are useful in cases where preferred routes such as the oral route are not available. However, low overall extent of delivery is…”
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Preparation and characterization of directly compactible layer-by-layer nanocoated cellulose by Strydom, Schalk J., Otto, Daniel P., Liebenberg, Wilna, Lvov, Yuri M., de Villiers, Melgardt M.

“…Microcrystalline cellulose is a commonly used direct compression tablet diluent and binder. It is derived from purified α-cellulose in an environmentally…”
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