Examination of the failure properties of the anterior cruciate ligament during the estrous cycle

Examination of the failure properties of the anterior cruciate ligament during the estrous cycle

The purpose of this study was to determine whether the mechanical properties of the rat anterior cruciate ligament (ACL) vary when tested in vitro at different stages of the estrous cycle. Sixty female rats were allocated to four groups according to their stage of the estrous cycle: diestrus ( n=16)...

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Bibliographic Details
Published in:The knee Vol. 12; no. 1; pp. 37 - 40
Main Authors: Rau, M.D., Renouf, D., Benfield, D., Otto, D.D., Thornton, G.M., Raso, V.J., Bagnall, K.M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 2005
Elsevier Limited
Subjects:
Animals
Anterior cruciate ligament
Anterior Cruciate Ligament - metabolism
Anterior Cruciate Ligament - physiopathology
Biomechanics
Estrogen Receptor alpha - metabolism
Estrogens
Estrous Cycle - physiology
Failure properties
Female
Health sciences
Hindlimb - physiology
Hormonal cycle
Hypotheses
Immunohistochemistry
In Vitro Techniques
Load
Mechanical properties
Mechanical testing
Menstruation
Rats
Rats, Sprague-Dawley
Rodents
Sheep
Stress, Mechanical
Studies
Weight-Bearing - physiology
Women
Immunohistochemistry
Mechanical testing
Failure properties
Anterior cruciate ligament
Hormonal cycle
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Summary:The purpose of this study was to determine whether the mechanical properties of the rat anterior cruciate ligament (ACL) vary when tested in vitro at different stages of the estrous cycle. Sixty female rats were allocated to four groups according to their stage of the estrous cycle: diestrus ( n=16), proestrus ( n=17), estrus ( n=13) and metestrus ( n=14). Right hindlimbs were harvested for mechanical testing and left hindlimbs were harvested for immunohistochemical staining to confirm the presence of the estrogen receptor. Results from the first relaxation test showed a significant difference between the estrus and proestrus stage, which was not observed in a second subsequent relaxation test. Likewise, no significant differences were found when comparing failure load and stiffness between the different stages of the estrous cycle. These results suggest that normal physiological fluctuations in estrogen during the estrous cycle did not alter the failure properties of the rat ACL.
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ISSN:0968-0160
1873-5800
DOI:10.1016/j.knee.2003.12.003