Search Results - "Ottewell, PD"

Abstract P3-07-14: Targeting ERR-α regulated lactate metabolism eliminates drug-resistant breast cancer cells by Quayle, L, Park, S, McDonnell, DP, Ottewell, PD, Holen, I

“…Novel therapeutic strategies to eliminate chemo-resistant tumour cells responsible for the development of secondary lesions are essential in order to prevent…”
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Abstract P1-05-01: Breast cancer cell-derived IL-1B drives metastasis and colonisation of the bone microenvironment by Ottewell, PD, Lefley, DV, Freeman, K, Gregory, WM, Hanby, AM, Spicer-Hadlington, AR, Liu, X, Bradbury, SM, Hambley, L, Allocca, G, Cookson, V, Kruithof de-Julio, M, Coleman, RE, Brown, JE, Holen, I, Tulotta, C

“…Background: Breast cancer bone metastases are incurable and new therapeutic targets needed. After homing and colonising bone, cancer cells remain dormant,…”
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Abstract P6-14-03: Zoledronic Acid Reduces Breast Tumour Growth When Combined with Chemotherapy — Emerging Evidence of Anti-Tumour Effects Outside Bone by Holen, I, Ottewell, PD, Coleman, RE

“…Background: There is accumulating evidence that zoledronic acid (zol) causes increased anti-tumour effects when added to chemotherapy. In model systems,…”
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P2-01-20: Reduced Plakoglobin Expression Increases the Metastatic Potential of Breast Cancer Cells by Ottewell, PD, Whitworth, J, Cross, SS, Nutter, FH, Holen, I

“…The majority of deaths from breast cancer are a result of metastases, however, little is understood about the genetic alterations underlying their onset. A…”
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Abstract PD07-08: Zoledronic acid specifically inhibits development of bone metastases in the post-menopausal setting – evidence from an in vivo breast cancer model by Holen, I, Wang, N, Reeves, KJ, Fowles, AM, Croucher, PI, Eaton, CL, Ottewell, PD

“…Background: A number of recent clinical trials have suggested that the benefits of adjuvant bone targeted treatments on risks of recurrence or death in early…”
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Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine by Marshman, Emma, Ottewell, Penelope D., Potten, Christopher S., Watson, Alastair J. M.

“…The aim of this study was to characterize the activation of caspase‐3 along the crypt/villus axis in the normal and irradiated intestine and to compare active…”
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Evaluation of the molecular mechanisms for the sequence-dependent, synergistic anti-tumour effects of doxorubicin and zoledronic acid in breast cancer by Ottewell, PD, Lefley, DV, Coleman, RE, Holen, I

“…Abstract #2151 Background: Recent reports suggest that zoledronic acid (Zometa®) may have anti-tumour effects outside the skeleton. We have previously shown…”
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Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid by Ottewell, PD, Lefley, DV, Coleman, RE, Holen, I

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Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid by Lefley, DV, Holen, I, Coleman, RE, Ottewell, PD

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Synergistic effects of cytotoxic drugs and antiresorptive agents in vitro and in vivo by Ottewell, PD, Jones, M, Coleman, RE, Holen, I

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Gastrin Increases Murine Intestinal Crypt Regeneration Following Injury by Ottewell, Penelope D., Duckworth, Carrie A., Varro, Andrea, Dimaline, Rod, Wang, Timothy C., Watson, Alastair J.M., Dockray, Graham J., Pritchard, D. Mark

“…Background & Aims: A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not…”
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COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo by Ottewell, P D, Varro, A, Dockray, G J, Kirton, C M, Watson, A J M, Wang, T C, Dimaline, R, Pritchard, D M

“…Transgenic mice (hGAS) that overexpress human progastrin are more susceptible than wild-type mice (FVB/N) to the induction of colonic aberrant crypt foci (ACF)…”
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Progastrin stimulates murine colonic epithelial mitosis after DNA damage by Ottewell, Penelope D, Watson, Alastair J.M, Wang, Timothy C, Varro, Andrea, Dockray, Graham J, Pritchard, D.Mark

“…Transgenic mice that overexpress progastrin are more susceptible than either wild-type mice or mice that overexpress amidated gastrin to chemical…”
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