Search Results - "Ottewell, D"

The role of osteoblasts in bone metastasis by Ottewell, Penelope D

“…Abstract The primary role of osteoblasts is to lay down new bone during skeletal development and remodelling. Throughout this process osteoblasts directly…”
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Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling by Eyre, Rachel, Alférez, Denis G., Santiago-Gómez, Angélica, Spence, Kath, McConnell, James C., Hart, Claire, Simões, Bruno M., Lefley, Diane, Tulotta, Claudia, Storer, Joanna, Gurney, Austin, Clarke, Noel, Brown, Mick, Howell, Sacha J., Sims, Andrew H., Farnie, Gillian, Ottewell, Penelope D., Clarke, Robert B.

“…Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before bone metastases…”
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Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment by Tulotta, Claudia, Lefley, Diane V, Freeman, Katy, Gregory, Walter M, Hanby, Andrew M, Heath, Paul R, Nutter, Faith, Wilkinson, J Mark, Spicer-Hadlington, Amy R, Liu, Xinming, Bradbury, Steven M J, Hambley, Lisa, Cookson, Victoria, Allocca, Gloria, Kruithof de Julio, Marianna, Coleman, Robert E, Brown, Janet E, Holen, Ingunn, Ottewell, Penelope D

“…Breast cancer bone metastases are incurable, highlighting the need for new therapeutic targets. After colonizing bone, breast cancer cells remain dormant,…”
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Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone by Ottewell, Penelope D, Wang, Ning, Meek, Joshua, Fowles, C Anne, Croucher, Peter I, Eaton, Colby L, Holen, Ingunn

“…Up to 90% of patients with castrate-resistant prostate cancer develop bone metastases, and the majority of these men have received androgen deprivation therapy…”
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The role of IL-1B in breast cancer bone metastasis by Zhou, Jiabao, Ottewell, Penelope D.

“…•Promoting EMT, vascular and immunological changes that drive tumour cells out of the primary site.•Regulates breast cancer cell homing to the bone…”
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Antitumor Effects of Doxorubicin Followed by Zoledronic Acid in a Mouse Model of Breast Cancer by Ottewell, Penelope D., Mönkkönen, Hannu, Jones, Mark, Lefley, Diane V., Coleman, Robert E., Holen, Ingunn

“…Background The potent antiresorptive drug zoledronic acid (Zol) enhances the antitumor effects of chemotherapy agents in vitro. We investigated the effects of…”
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Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer by Quayle, Lewis, Ottewell, Penelope D, Holen, Ingunn

“…Metastasis to the bone is most frequently observed in advanced cases of breast and prostate cancer. The latent development of overt metastatic lesions is…”
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The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo by Allocca, Gloria, Hughes, Russell, Wang, Ning, Brown, Hannah K, Ottewell, Penelope D, Brown, Nicola J, Holen, Ingunn

“…Background: Bone metastasis is one of the most common complications of advanced breast cancer. During dissemination to bone, breast cancer cells locate in a…”
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Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer by Brown, Hannah K, Allocca, Gloria, Ottewell, Penelope D, Wang, Ning, Brown, Nicola J, Croucher, Peter I, Eaton, Colby L, Holen, Ingunn

“…Breast cancer cells colonize the skeleton by homing to specific niches, but the involvement of osteoblasts in tumour cell seeding, colonization, and…”
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Oestradiol Contributes to Differential Antitumour Effects of Adjuvant Zoledronic Acid Observed Between Pre- and Post-Menopausal Women by Canuas-Landero, Victor G, George, Christopher N, Lefley, Diane V, Corness, Hannah, Muthana, Munitta, Wilson, Caroline, Ottewell, Penelope D

“…Clinical trials have demonstrated that adding zoledronic acid (Zol) to (neo)adjuvant standard of care has differential antitumour effects in pre- and…”
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Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model by Ottewell, Penelope D., Lefley, Diane V., Cross, Simon S., Evans, C. Alyson, Coleman, Robert E., Holen, Ingunn

“…Combination therapy, using agents that target the microenvironment as well as the cancer cells, is common in the treatment of advanced breast cancer. Here, we…”
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IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer by Tulotta, Claudia, Lefley, Diane V., Moore, Charlotte K., Amariutei, Ana E., Spicer-Hadlington, Amy R., Quayle, Lewis A., Hughes, Russell O., Ahmed, Khawla, Cookson, Victoria, Evans, Catherine A., Vadakekolathu, Jayakumar, Heath, Paul, Francis, Sheila, Pinteaux, Emmanuel, Pockley, A. Graham, Ottewell, Penelope D.

“…Breast cancer bone metastasis is currently incurable, ~75% of patients with late-stage breast cancer develop disease recurrence in bone and available…”
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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model by Morita, Mai, Arshad, Fawaz, Quayle, Lewis A., George, Christopher N., Lefley, Diane V., Kalajzic, Ivo, Balsubramanian, Meena, Cebe, Tugba, Reilly, Gwen, Bishop, Nicolas J., Ottewell, Penelope D.

“…Excessive production of Transforming Growth Factor β (TGFβ) is commonly associated with dominant and recessive forms of OI. Previous reports have indicated…”
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Differential Effect of Doxorubicin and Zoledronic Acid on Intraosseous versus Extraosseous Breast Tumor Growth In vivo by Ottewell, Penelope D, Deux, Blandine, Mönkkönen, Hannu, Cross, Simon, Coleman, Robert E, Clezardin, Philippe, Holen, Ingunn

“…Purpose: Breast cancer patients with bone metastases are commonly treated with chemotherapeutic agents such as doxorubicin and zoledronic acid to control their…”
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Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo by Holen, Ingunn, Whitworth, Jacob, Nutter, Faith, Evans, Alyson, Brown, Hannah K, Lefley, Diane V, Barbaric, Ivana, Jones, Mark, Ottewell, Penelope D

“…The majority of deaths from breast cancer are a result of metastases; however, little is understood about the genetic alterations underlying their onset…”
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Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone by Ottewell, Penelope D, Woodward, Julia K, Lefley, Diane V, Evans, C Alyson, Coleman, Robert E, Holen, Ingunn

“…Patients with advanced breast cancer frequently develop bone metastases, and at this stage, the disease is considered incurable. Here, we show that a 6-week…”
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Combined therapies of bone disease with bisphosphonates by Syddall, S P, Ottewell, P D, Holen, I

“…Bisphosphonates are standard treatment for cancer-induced bone disease, a common feature of many advanced malignancies. Traditionally used to inhibit bone…”
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A direct measurement of the 17O(α,γ)21Ne reaction in inverse kinematics and its impact on heavy element production by Taggart, M.P., Akers, C., Laird, A.M., Hager, U., Ruiz, C., Hutcheon, D.A., Bentley, M.A., Brown, J.R., Buchmann, L., Chen, A.A., Chen, J., Chipps, K.A., Choplin, A., D'Auria, J.M., Davids, B., Davis, C., Diget, C.Aa, Erikson, L., Fallis, J., Fox, S.P., Frischknecht, U., Fulton, B.R., Galinski, N., Greife, U., Hirschi, R., Howell, D., Martin, L., Mountford, D., Murphy, A.St.J., Ottewell, D., Pignatari, M., Reeve, S., Ruprecht, G., Sjue, S., Veloce, L., Williams, M.

“…During the slow neutron capture process in massive stars, reactions on light elements can both produce and absorb neutrons thereby influencing the final heavy…”
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Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine by Marshman, Emma, Ottewell, Penelope D., Potten, Christopher S., Watson, Alastair J. M.

“…The aim of this study was to characterize the activation of caspase‐3 along the crypt/villus axis in the normal and irradiated intestine and to compare active…”
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IL-1β in breast cancer bone metastasis by Zhou, Jiabao, Tulotta, Claudia, Ottewell, Penelope D

“…Bone is the most common site for advanced breast cancer to metastasise. The proinflammatory cytokine, interleukin-1β (IL-1β) plays a complex and contradictory…”
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