Search Results - "Ottesen, Lone Harild"

Granular analysis of individual immune-related gene expression in a randomized phase I/II study of the oncolytic adenovirus, ONCOS-102, in combination with pemetrexed/cisplatin (P/C) in patients (pts) with unresectable malignant pleural mesothelioma (MPM) by Hansen, Thomas Birkballe, Cedres Perez, Susana, Ricordel, Charles, Levitsky, Victor, Ottesen, Lone Harild, Paz-Ares, Luis G.

“…e20536 Background: ONCOS-102 is an oncolytic adenovirus expressing granulocyte-macrophage colony stimulating factor (GM-CSF; Ad5/3-D24-GMCSF) that stimulates…”
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A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma by Yau, Thomas C C, Lencioni, Riccardo, Sukeepaisarnjaroen, Wattana, Chao, Yee, Yen, Chia-Jui, Lausoontornsiri, Wirote, Chen, Pei-Jer, Sanpajit, Theeranun, Camp, Aaron, Cox, Donna S, Gagnon, Robert C, Liu, Yuan, Raffensperger, Kristen E, Kulkarni, Diptee A, Kallender, Howard, Ottesen, Lone Harild, Poon, Ronnie T P, Bottaro, Donald P

“…This phase I/II single-arm study evaluated the safety, pharmacokinetics, pharmacodynamics, and activity of foretinib, an oral multikinase inhibitor of MET,…”
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A Dose Finding Lead-in Study of E7777 (Diphtheria toxin fragment-Interleukin-2 Fusion Protein) in Persistent or Recurrent Cutaneous T-Cell Lymphoma (CTCL) by Duvic, Madeleine, Kuzel, Timothy M, Dang, Nam H., Prince, Miles, Feldman, Tatyana, Foss, Francine M., Guo, Matthew, Ottesen, Lone Harild, Ooi, Chean Eng, Kim, Youn H

“…Introduction: E7777 is a recombinant cytotoxic fusion protein composed of diphtheria toxin fragments A and B and human interleukin-2. E7777 has the same amino…”
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A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC) by Yau, Thomas Cheung, Sukeepaisarnjaroen, Wattana, Chao, Yee, Yen, Chia-Jui, Lausoontornsiri, Wirote, Chen, Pei-Jer, Sanpajit, Theeranun, Lencioni, Riccardo, Camp, Aaron C, Cox, Donna S, Kallender, Howard, Ottesen, Lone Harild, Poon, Ronnie Tung-Ping

“…Abstract only 4108 Background: Hepatocyte growth factor (HGF)/MET signalling plays a pivotal role in tumor cell proliferation, migration and invasion in HCC…”
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Correlation of germline MET mutation with response to the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Results from a multicenter phase II study (MET111644) by Srinivasan, Ramaprasad, Bottaro, Donald P., Choueiri, Toni K., Vaishampayan, Ulka N., Rosenberg, Jonathan E., Logan, Theodore, Harzstark, Andrea Lynne, Rini, Brian I., Srinivas, Sandy, Adams, Laurel M., Laubscher, Kevin, Ottesen, Lone Harild, McDermott, David F., Linehan, W. Marston

“…Abstract only 372 Background: Activating mutations and/or amplifications in MET have been described in patients (pts) with papillary renal cell carcinoma…”
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A phase II and biomarker study (MET111644) of the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Final efficacy, safety, and PD results by Choueiri, Toni K., Vaishampayan, Ulka N., Rosenberg, Jonathan E., Logan, Theodore, Harzstark, Andrea Lynne, Rini, Brian I., Srinivas, Sandy, Adams, Laurel M., Sherman, Laurie Jill, Ottesen, Lone Harild, McDermott, David F., Bottaro, Donald P., Linehan, W. Marston, Srinivasan, Ramaprasad

“…Abstract only 355 Background: Foretinib is an oral multi-kinase inhibitor targeting MET, VEGF, RON, AXL, and TIE-2 receptors. Activating mutations and/or…”
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Propranolol reduces the meal-induced increase in oxygen consumption in patients with cirrhosis by Ottesen, Lone Harild, Simonsen, Lene, Henriksen, Jens, Bendtsen, Flemming

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Effects of a long-acting formulation of octreotide on renal function and renal sodium handling in cirrhotic patients with portal hypertension: A randomized, double-blind, controlled trial by Ottesen, Lone Harild, Aagaard, Niels Kristian, Kiszka-Kanowitz, Marianne, Rehling, Michael, Henriksen, Jens Henrik, Pedersen, Erling Bjerregaard, Flyvbjerg, Allan, Bendtsen, Flemming

“…Octreotide seems to have a beneficial effect on variceal bleeding, and long-term administration for the prevention of rebleeding is currently being evaluated…”
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The pharmacokinetics of octreotide in cirrhosis and in healthy man by Ottesen, Lone Harild, Flyvbjerg, Allan, Jakobsen, Preben, Bendtsen, Flemming

“…Background/Aim: The aim of the study was to evaluate the pharmacokinetics of octreotide in patients with cirrhosis compared to healthy volunteers. Methods:…”
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Effects of octreotide on serum insulin-like growth factor I and insulin-like growth factor binding proteins in patients with cirrhosis by Ottesen, L. H., Frystyk, J., Kiszka-Kanowitz, M., Grønbæk, H., Bendtsen, F., Flyvbjerg, A.

“…Hyperinsulinaemia and reduced insulin sensitivity are common features in patients with cirrhosis. Octreotide, a long-acting somatostatin analogue, is used in…”
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The insulin-like growth factor binding protein 3 ternary complex is reduced in cirrhosis by Ottesen, Lone Harild, Bendtsen, Flemming, Flyvbjerg, Allan

“…: Background/Aims: In healthy adults, serum insulin‐like growth factor I (IGF‐I), IGF binding protein 3 (IGFBP‐3) and acid labile subunit (ALS) form a 150‐kDa…”
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