Search Results - "Otter, Silke"
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Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells
Published in Trends in endocrinology and metabolism (01-03-2016)“…Glutamate represents a key excitatory neurotransmitter in the central nervous system, and also modulates the function and viability of endocrine cells in…”
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Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment
Published in Nature medicine (01-04-2015)“…NMDA receptors in pancreatic beta cells inhibit glucose-stimulated insulin secretion, and inhibiting these receptors with an over-the-counter medication…”
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3
The biomechanical properties of an epithelial tissue determine the location of its vasculature
Published in Nature communications (20-12-2016)“…An important question is how growing tissues establish a blood vessel network. Here we study vascular network formation in pancreatic islets, endocrine tissues…”
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Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety
Published in Molecular metabolism (Germany) (01-09-2023)“…Dextromethorphan (DXM) is a commonly used antitussive medication with positive effects in people with type 2 diabetes mellitus, since it increases glucose…”
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Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Published in Cell chemical biology (21-10-2021)“…Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making…”
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NMDA receptor dependent anti-diabetic effects
Published in Molecular and cellular pediatrics (11-09-2014)Get full text
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