Search Results - "Ottenheijm, C. A. C"

Diaphragm contractile weakness due to reduced mechanical loading: role of titin by van der Pijl, Robbert J, Granzier, Henk L, Ottenheijm, Coen A C

“…The diaphragm, the main muscle of inspiration, is constantly subjected to mechanical loading. Only during controlled mechanical ventilation, as occurs during…”
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Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole by Methawasin, Mei, Hutchinson, Kirk R, Lee, Eun-Jeong, Smith, John E, Saripalli, Chandra, Hidalgo, Carlos G, Ottenheijm, Coen A.C, Granzier, Henk

“…BACKGROUND—Experimentally upregulating compliant titins has been suggested as a therapeutic for lowering pathological diastolic stiffness levels. However, how…”
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Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy by OTTENHEIJM, Coen A. C, LAWLOR, Michael W, STIENEN, Ger J. M, GRANZIER, Henk, BEGGS, Alan H

“…Nemaline myopathy, the most common non-dystrophic congenital myopathy, is caused by mutations in six genes, all of which encode thin-filament proteins,…”
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Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency by Ottenheijm, Coen A.C., Witt, Christian C., Stienen, Ger J., Labeit, Siegfried, Beggs, Alan H., Granzier, Henk

“…Nemaline myopathy (NM) is the most common non-dystrophic congenital myopathy. Clinically the most important feature of NM is muscle weakness; however, the…”
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Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension by Manders, Emmy, MSc, Bogaard, Harm-Jan, MD, PhD, Handoko, M. Louis, MD, PhD, van de Veerdonk, Marielle C., MD, Keogh, Anne, MD, Westerhof, Nico, PhD, Stienen, Ger J.M., PhD, dos Remedios, Cristobal G., PhD, Dsc, Humbert, Marc, MD, PhD, Dorfmüller, Peter, MD, PhD, Fadel, Elie, MD, PhD, Guignabert, Christophe, PhD, van der Velden, Jolanda, PhD, Vonk-Noordegraaf, Anton, MD, PhD, de Man, Frances S., PhD, Ottenheijm, Coen A.C., PhD

“…Abstract Background After lung transplantation, increased left ventricular (LV) filling can lead to LV failure, increasing the risk of post-operative…”
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Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease by Ottenheijm, Coen A. C, Heunks, Leo M. A, Sieck, Gary C, Zhan, Wen-Zhi, Jansen, Suzanne M, Degens, Hans, de Boo, Theo, Dekhuijzen, P. N. Richard

“…Hypercapnic respiratory failure because of inspiratory muscle weakness is the most important cause of death in chronic obstructive pulmonary disease (COPD)…”
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Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics by van de Locht, Martijn, Borsboom, Tamara C., Winter, Josine M., Ottenheijm, Coen A. C.

“…The troponin complex is a key regulator of muscle contraction. Multiple variants in skeletal troponin encoding genes result in congenital myopathies. TNNC2 has…”
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Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers by Shi, Zhonghua, de Vries, Heder J, Vlaar, Alexander P J, van der Hoeven, Johannes, Boon, Reinier A, Heunks, Leo M A, Ottenheijm, Coen A C

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Effects of diaphragm plication on pulmonary function and cardiopulmonary exercise parameters by Welvaart, Willem N, Jak, Patrick M C, van de Veerdonk, Mariëlle C, Marcus, Johannes T, Ottenheijm, Coen A C, Paul, Marinus A, Vonk Noordegraaf, Anton

“…Paralysis of the diaphragm is an uncommon condition, which may result in dyspnoea on excertion and in orthopnea. In patients who have symptoms, the paralysed…”
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Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers by Lindqvist, Johan, van den Berg, Marloes, van der Pijl, Robbert, Hooijman, Pleuni E, Beishuizen, Albertus, Elshof, Judith, de Waard, Monique, Girbes, Armand, Spoelstra-de Man, Angelique, Shi, Zhong-Hua, van den Brom, Charissa, Bogaards, Sylvia, Shen, Shengyi, Strom, Joshua, Granzier, Henk, Kole, Jeroen, Musters, René J P, Paul, Marinus A, Heunks, Leo M A, Ottenheijm, Coen A C

“…Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay and increases mortality and healthcare costs. The…”
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Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients by Hooijman, Pleuni E, Beishuizen, Albertus, Witt, Christian C, de Waard, Monique C, Girbes, Armand R J, Spoelstra-de Man, Angelique M E, Niessen, Hans W M, Manders, Emmy, van Hees, Hieronymus W H, van den Brom, Charissa E, Silderhuis, Vera, Lawlor, Michael W, Labeit, Siegfried, Stienen, Ger J M, Hartemink, Koen J, Paul, Marinus A, Heunks, Leo M A, Ottenheijm, Coen A C

“…The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity and duration…”
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Activation of the Ubiquitin-Proteasome Pathway in the Diaphragm in Chronic Obstructive Pulmonary Disease by Ottenheijm, Coen A. C, Heunks, Leo M. A, Li, Yi-Ping, Jin, Bingwen, Minnaard, Ronnie, van Hees, Hieronymus W. H, Dekhuijzen, P. N. Richard

“…Studies show that the myosin content of the diaphragm in patients with mild to moderate chronic obstructive pulmonary disease (COPD) is reduced, compromising…”
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Positive end-expiratory pressure affects geometry and function of the human diaphragm by Jansen, Diana, Jonkman, Annemijn H., Vries, Heder J. de, Wennen, Myrte, Elshof, Judith, Hoofs, Maud A., van den Berg, Marloes, Man, Angélique M. E. de, Keijzer, Christiaan, Scheffer, Gert-Jan, van der Hoeven, Johannes G., Girbes, Armand, Tuinman, Pieter Roel, Marcus, J. Tim, Ottenheijm, Coen A. C., Heunks, Leo

“…We demonstrate that PEEP causes changes in diaphragm geometry, especially muscle shortening, and decreases in vivo diaphragm contractile function. Thus…”
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Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength by Greising, Sarah M, Ottenheijm, Coen A C, O'Halloran, Ken D, Barreiro, Esther

“…The diaphragm is the main inspiratory muscle and is required to be highly active throughout the life span. The diaphragm muscle must be able to produce and…”
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Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb by Laitila, Jenni M, McNamara, Elyshia L, Wingate, Catherine D, Goullee, Hayley, Ross, Jacob A, Taylor, Rhonda L, van der Pijl, Robbert, Griffiths, Lisa M, Harries, Rachel, Ravenscroft, Gianina, Clayton, Joshua S, Sewry, Caroline, Lawlor, Michael W, Ottenheijm, Coen A C, Bakker, Anthony J, Ochala, Julien, Laing, Nigel G, Wallgren-Pettersson, Carina, Pelin, Katarina, Nowak, Kristen J

“…Nemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant…”
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Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension by Rain, Silvia, Handoko, M Louis, Trip, Pia, Gan, C Tji-Joong, Westerhof, Nico, Stienen, Ger J, Paulus, Walter J, Ottenheijm, Coen A.C, Marcus, J Tim, Dorfmüller, Peter, Guignabert, Christophe, Humbert, Marc, MacDonald, Peter, dos Remedios, Cris, Postmus, Piet E, Saripalli, Chandra, Hidalgo, Carlos G, Granzier, Henk L, Vonk-Noordegraaf, Anton, van der Velden, Jolanda, de Man, Frances S

“…BACKGROUND—The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated…”
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Rbm20 ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness by van den Berg, Marloes, Peters, Eva L, van der Pijl, Robbert J, Shen, Shengyi, Heunks, Leo M A, Granzier, Henk L, Ottenheijm, Coen A C

“…Diaphragm weakness frequently develops in mechanically ventilated critically ill patients and is associated with increased morbidity, including ventilator…”
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Titin and diaphragm dysfunction in mechanically ventilated rats by van Hees, Hieronymus W. H., Schellekens, Willem-Jan M., Andrade Acuña, Gilberto L., Linkels, Marianne, Hafmans, Theo, Ottenheijm, Coen A. C., Granzier, Henk L., Scheffer, Gert-Jan, van der Hoeven, Johannes G., Dekhuijzen, P. N. Richard, Heunks, Leo M. A.

“…Purpose Diaphragm weakness induced by mechanical ventilation may contribute to difficult weaning from the ventilator. For optimal force generation the muscle…”
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The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles by van der Pijl, Robbert J., Domenighetti, Andrea A., Sheikh, Farah, Ehler, Elisabeth, Ottenheijm, Coen A. C., Lange, Stephan

“…Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres, costameres or the…”
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Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats by van Hees, Hieronymus W H, van der Heijden, Henricus F M, Ottenheijm, Coen A C, Heunks, Leo M A, Pigmans, Cindy J C, Verheugt, Freek W A, Brouwer, Rene M H J, Dekhuijzen, P N Richard

“…Diaphragm weakness commonly occurs in patients with congestive heart failure (CHF) and is an independent predictor of mortality. However, the pathophysiology…”
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