Search Results - "Ottenberg, Gregory"
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Sphingolipid-Containing Outer Membrane Vesicles Serve as a Delivery Vehicle To Limit Macrophage Immune Response to Porphyromonas gingivalis
Published in Infection and immunity (17-03-2021)“…Sphingolipids (SLs) are essential structural components of mammalian cell membranes. Our group recently determined that the oral anaerobe delivers its SLs to…”
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Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2013)“…Prion diseases such as Creutzfeldt–Jakob disease (CJD) are incurable and rapidly fatal neurodegenerative diseases. Because prion protein (PrP) is necessary for…”
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Highly neurotoxic monomeric α-helical prion protein
Published in Proceedings of the National Academy of Sciences - PNAS (21-02-2012)“…Prion diseases are infectious and belong to the group of protein misfolding neurodegenerative diseases. In these diseases, neuronal dysfunction and death are…”
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Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381
Published in NPJ biofilms and microbiomes (07-02-2019)“…Porphyromonas gingivalis is the only known human-associated prokaryote that produces a peptidylarginine deiminase (PPAD), a protein-modifying enzyme that is…”
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Strain-Specific Role of RNAs in Prion Replication
Published in Journal of Virology (01-10-2012)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P
Published in Microbiology spectrum (27-04-2022)“…Like other members of the phylum , the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host. Studies have…”
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Citrullination mediated by PPAD constrains biofilm formation in P. gingivalis strain 381
Published in NPJ biofilms and microbiomes (07-02-2019)“…Porphyromonas gingivalis is the only known human-associated prokaryote that produces a peptidylarginine deiminase (PPAD), a protein-modifying enzyme that is…”
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The fluorescent protein color palette
Published in Current protocols in cell biology (01-09-2007)“…Advances in fluorescent protein development over the past 10 years have led to fine-tuning of the Aequorea victoria jellyfish color palette in the emission…”
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Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
Published in Brain (London, England : 1878) (01-04-2015)“…The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases are poorly understood. We…”
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Enhanced purification coupled with biophysical analyses shows cross-β structure as a core building block for Streptococcus mutans functional amyloids
Published in Scientific reports (20-03-2020)“…Streptococcus mutans is an etiologic agent of human dental caries that forms dental plaque biofilms containing functional amyloids. Three amyloidogenic…”
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Neuronal death induced by misfolded prion protein is due to NAD super(+) depletion and can be relieved in vitro and in vivo by NAD super(+) replenishment
Published in Brain (London, England : 1878) (01-04-2015)“…The mechanisms by which misfolded proteins trigger neurodegeneration remain unclear. Zhou et al. show that the misfolded prion protein TPrP triggers abnormal…”
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Highly neurotoxic monomeric [alpha]-helical prion protein
Published in Proceedings of the National Academy of Sciences - PNAS (21-02-2012)“…Prion diseases are infectious and belong to the group of protein misfolding neurodegenerative diseases. In these diseases, neuronal dysfunction and death are…”
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