Search Results - "Otten, Jeroen"

Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner by Borissoff, Julian I, Otten, Jeroen J T, Heeneman, Sylvia, Leenders, Peter, van Oerle, René, Soehnlein, Oliver, Loubele, Sarah T B G, Hamulyák, Karly, Hackeng, Tilman M, Daemen, Mat J A P, Degen, Jay L, Weiler, Hartmut, Esmon, Charles T, van Ryn, Joanne, Biessen, Erik A L, Spronk, Henri M H, ten Cate, Hugo

“…Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic…”
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Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage‐specific Fas‐induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics by Medina, Indira, Wieland, Elias B, Temmerman, Lieve, Otten, Jeroen J.T., Bermudez, Beatriz, Bot, Ilze, Rademakers, Timo, Wijnands, Erwin, Schurgers, Leon, Mees, Barend, Berkel, Theo J.C., Goossens, Pieter, Biessen, Erik A.L.

“…Macrophage infiltration and accumulation in the atherosclerotic lesion are associated with plaque progression and instability. Depletion of macrophages from…”
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Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis by Rademakers, Timo, van der Vorst, Emiel P. C., Daissormont, Isabelle T. M. N., Otten, Jeroen J. T., Theodorou, Kosta, Theelen, Thomas L., Gijbels, Marion, Anisimov, Andrey, Nurmi, Harri, Lindeman, Jan H. N., Schober, Andreas, Heeneman, Sylvia, Alitalo, Kari, Biessen, Erik A. L.

“…During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here…”
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Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients by Lu, Chang, Donners, Marjo M P C, de Baaij, Julius B J, Jin, Han, Otten, Jeroen J T, Manca, Marco, van Zonneveld, Anton Jan, Jukema, J Wouter, Kraaijeveld, Adriaan, Kuiper, Johan, Pasterkamp, Gerard, Mees, Barend, Sluimer, Judith C, Cavill, Rachel, Karel, Joël M H, Goossens, Pieter, Biessen, Erik A L

“…The impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of…”
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Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice by Skarpengland, Tonje, Holm, Sverre, Scheffler, Katja, Gregersen, Ida, Dahl, Tuva B., Suganthan, Rajikala, Segers, Filip M., Østlie, Ingunn, Otten, Jeroen J. T., Luna, Luisa, Ketelhuth, Daniel F. J., Lundberg, Anna M., Neurauter, Christine G., Hildrestrand, Gunn, Skjelland, Mona, Bjørndal, Bodil, Svardal, Asbjørn M., Iversen, Per O., Hedin, Ulf, Nygård, Ståle, Olstad, Ole K., Krohg-Sørensen, Kirsten, Slupphaug, Geir, Eide, Lars, Kuśnierczyk, Anna, Folkersen, Lasse, Ueland, Thor, Berge, Rolf K., Hansson, Göran K., Biessen, Erik A. L., Halvorsen, Bente, Bjørås, Magnar, Aukrust, Pål

“…Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair…”
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Hematopoietic G‐protein‐coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor‐knockout mice by Otten, Jeroen J. T., Jager, Saskia C. A., Kavelaars, Annemieke, Seijkens, Tom, Bot, Ilze, Wijnands, Erwin, Beckers, Linda, Westra, Marijke M., Bot, Martine, Busch, Matthias, Bermudez, Beatriz, Berkel, Theo J. C., Heijnen, Cobi J., Biessen, Erik A. L.

“…Leukocyte chemotaxis is deemed instrumental in initiation and progression of atherosclerosis. It is mediated by G‐protein‐coupled receptors (e.g., CCR2 and…”
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In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells by Christ, Anette, Maas, Sanne L., Jin, Han, Lu, Chang, Legein, Bart, Wijnands, Erwin, Temmerman, Lieve, Otten, Jeroen, Isaacs, Aaron, Zenke, Martin, Stoll, Monika, Biessen, Erik A.L., van der Vorst, Emiel P.C.

“…Dendritic cells (DCs), professional antigen-presenting cells, play an important role in pathologies by controlling adaptive immune responses. However, their…”
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Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function by Bermudez, Beatriz, Dahl, Tuva Borresdatter, Medina, Indira, Groeneweg, Mathijs, Holm, Sverre, Montserrat-de la Paz, Sergio, Rousch, Mat, Otten, Jeroen, Herias, Veronica, Varela, Lourdes M, Ranheim, Trine, Yndestad, Arne, Ortega-Gomez, Almudena, Abia, Rocio, Nagy, Laszlo, Aukrust, Pal, Muriana, Francisco J G, Halvorsen, Bente, Biessen, Erik Anna Leonardus

“…Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular…”
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