Search Results - "Otten, Auke B.C."

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells by Otten, Auke B.C., Theunissen, Tom E.J., Derhaag, Josien G., Lambrichs, Ellen H., Boesten, Iris B.W., Winandy, Marie, van Montfoort, Aafke P.A., Tarbashevich, Katsiaryna, Raz, Erez, Gerards, Mike, Vanoevelen, Jo M., van den Bosch, Bianca J.C., Muller, Marc, Smeets, Hubert J.M.

“…We studied the mtDNA bottleneck in zebrafish to elucidate size, timing, and variation in germline and non-germline cells. Mature zebrafish oocytes contain, on…”
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A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis by Cai, Pengfei, Otten, Auke B C, Cheng, Binbin, Ishii, Mitsuhiro A, Zhang, Wen, Huang, Beibei, Qu, Kun, Sun, Bryan K

“…Genome-wide association studies indicate that many disease susceptibility regions reside in non-protein-coding regions of the genome. Long noncoding RNAs…”
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Alternative mRNA splicing events and regulators in epidermal differentiation by Takashima, Shota, Sun, Wujianan, Otten, Auke B.C., Cai, Pengfei, Peng, Shaohong Isaac, Tong, Elton, Bui, Jolina, Mai, McKenzie, Amarbayar, Oyumergen, Cheng, Binbin, Odango, Rowen Jane, Li, Zongkai, Qu, Kun, Sun, Bryan K.

“…Alternative splicing (AS) of messenger RNAs occurs in ∼95% of multi-exon human genes and generates diverse RNA and protein isoforms. We investigated AS events…”
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The Long Noncoding RNA PRANCR Is Associated with Alternative Splicing of Fibronectin-1 in Keratinocytes by Otten, Auke B.C., Amarbayar, Oyumergen, Cai, Pengfei, Cheng, Binbin, Qu, Kun, Sun, Bryan K.

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Research Techniques Made Simple: CRISPR Genetic Screens by Otten, Auke B.C., Sun, Bryan K.

“…CRISPR and Cas proteins, often referred to as CRISPR/Cas, are the components of a bacterial genome editing system that can be used to perturb genes in cells…”
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Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing by Otten, Auke B C, Smeets, Hubert J M

“…The endosymbiosis of an alpha-proteobacterium and a eubacterium a billion years ago paved the way for multicellularity and enabled eukaryotes to flourish. The…”
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Mutation-specific effects in germline transmission of pathogenic mtDNA variants by Otten, Auke B C, Sallevelt, Suzanne C E H, Carling, Phillippa J, Dreesen, Joseph C F M, Drüsedau, Marion, Spierts, Sabine, Paulussen, Aimee D C, de Die-Smulders, Christine E M, Herbert, Mary, Chinnery, Patrick F, Samuels, David C, Lindsey, Patrick, Smeets, Hubert J M

“…Abstract STUDY QUESTION Does germline selection (besides random genetic drift) play a role during the transmission of heteroplasmic pathogenic mitochondrial…”
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HOPX Is a ZNF750 Target that Promotes Late Epidermal Differentiation by Chen, Selena Y., Ishii, Mitsuhiro A., Cheng, Binbin, Otten, Auke B.C., Sun, Bryan K.

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Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small-fiber neuropathy by Eijkenboom, Ivo, Sopacua, Maurice, Otten, Auke B.C., Gerrits, Monique M., Hoeijmakers, Janneke G.J., Waxman, Stephen G., Lombardi, Raffaella, Lauria, Giuseppe, Merkies, Ingemar S.J., Smeets, Hubert J.M., Faber, Catharina G., Vanoevelen, Jo M.

“…Small-fiber neuropathy (SFN) patients experience a spectrum of sensory abnormalities, including attenuated responses to non-noxious temperatures in combination…”
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Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos by Otten, Auke B C, Kamps, Rick, Lindsey, Patrick, Gerards, Mike, Pendeville-Samain, Hélène, Muller, Marc, van Tienen, Florence H J, Smeets, Hubert J M

“…High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and embryogenesis and correlate with fertility of oocytes and viability of embryos. To…”
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Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number by Otten, Auke B C, Stassen, Alphons P M, Adriaens, Michiel, Gerards, Mike, Dohmen, Richard G J, Timmer, Adriana J, Vanherle, Sabina J V, Kamps, Rick, Boesten, Iris B W, Vanoevelen, Jo M, Muller, Marc, Smeets, Hubert J M

“…Of all pathogenic mitochondrial DNA (mtDNA) mutations in humans, ∼25% is de novo, although the occurrence in oocytes has never been directly assessed. We used…”
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