Search Results - "Otte, Ryan D"

Transition-Metal-Catalyzed Aldehydic C−H Activation by Azodicarboxylates by Lee, Daesung, Otte, Ryan D

“…Rhodium acetate-catalyzed hydroacylation between aldehydes and an activated form of NN bond was achieved under mild conditions to provide efficient access to…”
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Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera by Kraus, Manfred, Wang, Yuxun, Aleksandrowicz, Dan, Bachman, Eric, Szewczak, Alexander A, Walker, Deborah, Xu, Lin, Bouthillette, Melaney, Childers, Kaleen M, Dolinski, Brian, Haidle, Andrew M, Kopinja, Johnny, Lee, Linda, Lim, Jongwon, Little, Kevin D, Ma, Yanhong, Mathur, Anjili, Mo, Jan-Rung, O'Hare, Erin, Otte, Ryan D, Taoka, Brandon M, Wang, Wenxian, Yin, Hong, Zabierek, Anna A, Zhang, Weisheng, Zhao, Shuxia, Zhu, Joe, Young, Jonathan R, Marshall, C Gary

“…A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2)…”
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Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor by Ma, Xiaoshen, Sloman, David L., Duggal, Ruchia, Anderson, Kenneth D., Ballard, Jeanine E., Bharathan, Indu, Brynczka, Christopher, Gathiaka, Symon, Henderson, Timothy J., Lyons, Thomas W., Miller, Richard, Munsell, Erik V., Orth, Peter, Otte, Ryan D., Palani, Anandan, Rankic, Danica A., Robinson, Michelle R., Sather, Aaron C., Solban, Nicolas, Song, Xuelei Sherry, Wen, Xin, Xu, Zangwei, Yang, Yi, Yang, Ruojing, Day, Phil J., Stoeck, Alexander, Bennett, David Jonathan, Han, Yongxin

“…Oncogenic mutations in the RAS gene account for 30% of all human tumors; more than 60% of which present as KRAS mutations at the hotspot codon 12. After…”
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Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor by Ma, Xiaoshen, Sloman, David L, Duggal, Ruchia, Anderson, Kenneth D, Ballard, Jeanine E, Bharathan, Indu, Brynczka, Christopher, Gathiaka, Symon, Henderson, Timothy J, Lyons, Thomas W, Miller, Richard, Munsell, Erik V, Orth, Peter, Otte, Ryan D, Palani, Anandan, Rankic, Danica A, Robinson, Michelle R, Sather, Aaron C, Solban, Nicolas, Song, Xuelei Sherry, Wen, Xin, Xu, Zangwei, Yang, Yi, Yang, Ruojing, Day, Phil J, Stoeck, Alexander, Bennett, David Jonathan, Han, Yongxin

“…Oncogenic mutations in the gene account for 30% of all human tumors; more than 60% of which present as KRAS mutations at the hotspot codon 12. After decades of…”
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Discovery of 1-Amino-5H-pyrido[4,3-b]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders by Lim, Jongwon, Taoka, Brandon, Otte, Ryan D, Spencer, Kerrie, Dinsmore, Christopher J, Altman, Michael D, Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A, Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R

“…The JAK-STAT pathway mediates signaling by cytokines, which control survival, proliferation, and differentiation of a variety of cells. In recent years, a…”
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Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors by Ellis, J. Michael, Altman, Michael D, Bass, Alan, Butcher, John W, Byford, Alan J, Donofrio, Anthony, Galloway, Sheila, Haidle, Andrew M, Jewell, James, Kelly, Nancy, Leccese, Erica K, Lee, Sandra, Maddess, Matthew, Miller, J. Richard, Moy, Lily Y, Osimboni, Ekundayo, Otte, Ryan D, Reddy, M. Vijay, Spencer, Kerrie, Sun, Binyuan, Vincent, Stella H, Ward, Gwendolyn J, Woo, Grace H. C, Yang, Chiming, Houshyar, Hani, Northrup, Alan B

“…Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were…”
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Reactivity of Mitsunobu Reagent toward Carbonyl Compounds by Otte, Ryan D., Sakata, Tomoyo, Guzei, Ilia A., Lee, Daesung

“…The nitrogen-based nucleophile generated from azodicarboxylate and triphenylphosphine displayed an excellent reactivity toward carbonyl compounds to generate a…”
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Reactivity of Mitsunobu Reagent toward Carbonyl Compounds by Otte, Ryan D, Sakata, Tomoyo, Guzei, Ilia A, Lee, Daesung

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Abstract 2097: ABT co-dose accelerated target validation with a fit-for-purpose HPK1 inhibitor tool by Methot, Joey L., Chen, Joanna L., Yu, Elsie, Otte, Ryan D., Xu, Haiyan, Xu, Zangwei, Lacey, Brian, Laskey, Jason, Mcleod, Robbie, Smith, Dustin, Pasternak, Alexander

“…Abstract Target validation can be challenging when mouse efficacy studies require achieving a high therapeutic exposure of a tool compound, ideally with a low…”
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Discovery of 1-Amino-5 H -pyrido[4,3- b ]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders by Lim, Jongwon, Taoka, Brandon, Otte, Ryan D., Spencer, Kerrie, Dinsmore, Christopher J., Altman, Michael D., Chan, Grace, Rosenstein, Craig, Sharma, Sujata, Su, Hua-Poo, Szewczak, Alexander A., Xu, Lin, Yin, Hong, Zugay-Murphy, Joan, Marshall, C. Gary, Young, Jonathan R.

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Tandem dienyne ring-closing metathesis of alkynyl silaketals for the formation of bicyclic siloxanes by Grimm, Jonathan B., Otte, Ryan D., Lee, Daesung

“…The tandem dienyne ring-closing metathesis of alkynyl silaketals containing two tethered olefins was achieved with second generation Grubbs NHC-ruthenium…”
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