Search Results - "Otte, Andrew"

Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation by Park, Kinam, Skidmore, Sarah, Hadar, Justin, Garner, John, Park, Haesun, Otte, Andrew, Soh, Bong Kwan, Yoon, Gwangheum, Yu, Dijia, Yun, Yeonhee, Lee, Byung Kook, Jiang, Xiaohui, Wang, Yan

“…Injectable, long-acting depot formulations based on poly(lactide-co-glycolide) (PLGA) have been used clinically since 1989. Despite 30 years of development,…”
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Matrix-assisted cocrystallization (MAC) simultaneous production and formulation of pharmaceutical cocrystals by hot-melt extrusion by Boksa, Kevin, Otte, Andrew, Pinal, Rodolfo

“…A novel method for the simultaneous production and formulation of pharmaceutical cocrystals, matrix-assisted cocrystallization (MAC), is presented. Hot-melt…”
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Assessment of milling-induced disorder of two pharmaceutical compounds by Otte, Andrew, Carvajal, M Teresa

“…The goal of this study was to provide a better framework for understanding the bulk and surface disorder in milled crystalline materials. The surface and bulk…”
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Physicomechanical and antibacterial properties of experimental resin-based dental sealants modified with nylon-6 and chitosan nanofibers by Hamilton, María F, Otte, Andrew D, Gregory, Richard L, Pinal, Rodolfo, Ferreira-Zandoná, Andrea, Bottino, Marco C

“…This study aimed to develop and evaluate resin-based experimental dental sealants containing electrospun nylon-6 (N6) and chitosan (CH) fibers in an attempt to…”
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Investigation of Film with β-Galactosidase Designed for Stabilization and Handling in Dry Configuration by Zhang, Liguang, Otte, Andrew, Xiang, Min, Liu, Dexiu, Pinal, Rodolfo

“…Gelatin-based films with an immobilized enzyme designed for extending the stability of the protein in dry, non-powder configuration with precise dosing…”
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Evolution of drug delivery systems: From 1950 to 2020 and beyond by Park, Haesun, Otte, Andrew, Park, Kinam

“…Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-release capsule technology, which can deliver a drug for 12 h after…”
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Transitioning from a lab-scale PLGA microparticle formulation to pilot-scale manufacturing by Otte, Andrew, Park, Kinam

“…The complexity of scale-up manufacturing of PLGA microparticles creates a significant challenge when transitioning from benchtop-scale formulation development…”
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Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities by Park, Kinam, Otte, Andrew

“…Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent…”
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The Impact of Post-Processing Temperature on PLGA Microparticle Properties by Otte, Andrew, Soh, Bong Kwan, Park, Kinam

“…Purpose Biodegradable poly(lactide-co-glycolide) (PLGA) microparticles loaded with either risperidone or naltrexone were prepared from an emulsification…”
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Perspective on drug delivery in 2050 by Park, Kinam, Otte, Andrew, Park, Haesun

“…[Display omitted]…”
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Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution by Park, Kinam, Otte, Andrew, Li, Tonglei

“…Controlled drug delivery technology has matured for more than 70 years, starting from a twice-a-day oral formulation to 6 month long-acting injectable…”
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Implications of particle size on the respective solid-state properties of naltrexone in PLGA microparticles by Otte, Andrew, Turasan, Hazal, Park, Kinam

“…[Display omitted] A thorough understanding of the complexities in formulating and manufacturing polymeric microspheres is required for new and generic drug…”
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Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles by Sharifi, Farrokh, Otte, Andrew, Yoon, Gwangheum, Park, Kinam

“…Injectable, long-acting drug delivery systems provide effective drug concentrations in the blood for up to 6 months. Naltrexone-loaded…”
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In vitro-in vivo correlation (IVIVC) development for long-acting injectable drug products based on poly(lactide-co-glycolide) by Wang, Yan, Otte, Andrew, Park, Haesun, Park, Kinam

“…In vitro-in vivo correlation (IVIVC), linking in vitro drug release to in vivo drug release or in vivo drug absorption, has been explored chiefly for oral…”
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Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles by Park, Kinam, Otte, Andrew, Sharifi, Farrokh, Garner, John, Skidmore, Sarah, Park, Haesun, Jhon, Young Kuk, Qin, Bin, Wang, Yan

“…Injectable long-acting formulations, specifically poly(lactide-co-glycolide) (PLGA) based systems, have been used to deliver drugs systemically for up to…”
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Interfacial tension effects on the properties of PLGA microparticles by Otte, Andrew, Sharifi, Farrokh, Park, Kinam

“…[Display omitted] •Interfacial tension effects can impact droplet deformation through drug release.•Solvent(s) and emulsifier(s) can alter the drug…”
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Coupling the in vivo performance to the in vitro characterization of PLGA microparticles by Otte, Andrew, Damen, Frederick, Goergen, Craig, Park, Kinam

“…[Display omitted] The main objective of the study was to determine if rodent housing conditions, specifically housing climate, could impact the in vivo…”
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Initial Formation of the Skin Layer of PLGA Microparticles by Sharifi, Farrokh, Otte, Andrew, Park, Kinam

“…Poly(lactide‐co‐glycolide) (PLGA) has been extensively used in making long‐acting injectable formulations. The critical factors affecting the PLGA formulation…”
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Potential Roles of the Glass Transition Temperature of PLGA Microparticles in Drug Release Kinetics by Park, Kinam, Otte, Andrew, Sharifi, Farrokh, Garner, John, Skidmore, Sarah, Park, Haesun, Jhon, Young Kuk, Qin, Bin, Wang, Yan

“…Poly(lactic- -glycolic acid) (PLGA) has been used for long-acting injectable drug delivery systems for more than 30 years. The factors affecting the properties…”
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Liquid crystalline drug delivery vehicles for oral and IV/subcutaneous administration of poorly soluble (and soluble) drugs by Otte, Andrew, Soh, Bong-Kwan, Yoon, Gwangheum, Park, Kinam

“…[Display omitted] Poorly soluble drug molecules often have low bioavailability issues and absorption problems in the clinical setting. As the number of poorly…”
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