Search Results - "Ottaviano, Giorgio"

Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in 'off the shelf' chimeric antigen receptor T-cell therapies to widen transplant options by Georgiadis, Christos, Nickolay, Lauren, Syed, Farhatullah, Zhan, Hong, Gkazi, Soragia Athina, Etuk, Annie, Abramowski-Mock, Ulrike, Preece, Roland, Cuber, Piotr, Adams, Stuart, Ottaviano, Giorgio, Qasim, Waseem

“…Umbilical cord blood (UCB) T cells exhibit distinct naive ontogenetic profiles and may be an attractive source of starting cells for the production of chimeric…”
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Towards personalized vaccines by Montin, Davide, Santilli, Veronica, Beni, Alessandra, Costagliola, Giorgio, Martire, Baldassarre, Mastrototaro, Maria Felicia, Ottaviano, Giorgio, Rizzo, Caterina, Sgrulletti, Mayla, Miraglia Del Giudice, Michele, Moschese, Viviana

“…The emergence of vaccinomics and system vaccinology represents a transformative shift in immunization strategies, advocating for personalized vaccines tailored…”
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Pubertal attainment and Leydig cell function following pediatric hematopoietic stem cell transplantation: a three-decade longitudinal assessment by Cattoni, Alessandro, Nicolosi, Maria Laura, Capitoli, Giulia, Gadda, Alberto, Molinari, Silvia, Louka, Sotiris, Buonsante, Andrea, Orlandi, Simona, Salierno, Gianluca, Bellani, Iacopo, Vendemini, Francesca, Ottaviano, Giorgio, Gaiero, Alberto, Fichera, Graziella, Biondi, Andrea, Balduzzi, Adriana

“…Impaired testosterone secretion is a frequent following hematopoietic stem cell transplantation (HSCT) in pediatrics, but long-term longitudinal trendlines of…”
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A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome by Ottaviano, Giorgio, Gerosa, Jolanda, Santini, Micaela, De Leo, Pasqualina, Vecchione, Andrea, Jofra, Tatiana, Trimarchi, Cristiana, De Pellegrin, Maurizio, Agosti, Massimo, Aiuti, Alessandro, Marinoni, Maddalena, Cicalese, Maria Pia, Fousteri, Georgia

“…Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that are suggestive of humoral…”
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CAN A THIRD HAEMATOPOIETIC STEM CELL TRANSPLANTATION BE A VIABLE OPTION FOR JMML RELAPSE? A CASE REPORT by Vendemini, Francesca, Bonanomi, Sonia, Verna, Marta, Ottaviano, Giorgio, Casartelli, Pietro, Saettini, Francesco, Balduzzi, Adriana

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B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome by Castiello, Maria Carmina, PhD, Scaramuzza, Samantha, PhD, Pala, Francesca, MS, Ferrua, Francesca, MD, Uva, Paolo, PhD, Brigida, Immacolata, PhD, Sereni, Lucia, MS, van der Burg, Mirjam, PhD, Ottaviano, Giorgio, MD, Albert, Michael H., MD, Grazia Roncarolo, Maria, MD, Naldini, Luigi, MD, PhD, Aiuti, Alessandro, MD, PhD, Villa, Anna, MD, Bosticardo, Marita, PhD

“…Background Wiskott-Aldrich syndrome (WAS) is a severe X-linked immunodeficiency characterized by microthrombocytopenia, eczema, recurrent infections, and…”
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Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation by Ottaviano, Giorgio, Chiesa, Robert, Feuchtinger, Tobias, Vickers, Mark A, Dickinson, Anne, Gennery, Andrew R, Veys, Paul, Todryk, Stephen

“…Adverse outcomes following virus-associated disease in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT) have encouraged strategies…”
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Genome-Edited T Cell Therapies by Ottaviano, Giorgio, Qasim, Waseem

“…Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility…”
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Secondary rituximab‐associated versus primary immunodeficiencies: The enigmatic border by Ottaviano, Giorgio, Sgrulletti, Mayla, Moschese, Viviana

“…Rituximab (RTX), a chimeric monoclonal antibody targeting CD20‐positive cells, is a valuable treatment option for malignant and benign immune‐related…”
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Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia by Chiesa, Robert, Georgiadis, Christos, Syed, Farhatullah, Zhan, Hong, Etuk, Annie, Gkazi, Soragia Athina, Preece, Roland, Ottaviano, Giorgio, Braybrook, Toni, Chu, Jan, Kubat, Agnieszka, Adams, Stuart, Thomas, Rebecca, Gilmour, Kimberly, O’Connor, David, Vora, Ajay, Qasim, Waseem

“…Three patients with T-cell ALL were treated with allogeneic CAR T cells that were base-edited to prevent CAR T-cell fratricide and graft-versus-host disease…”
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Prevalence and Characteristics of Non-tuberculous Mycobacteria (NTM) Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-analysis by Cinicola, Bianca Laura, Ottaviano, Giorgio, Hashim, Ilie Fadzilah, Zainudeen, Zarina Thasneem, Hamid, Intan Juliana Abd, Elfeky, Reem

“…Purpose Non-tuberculous mycobacteria (NTM) infections in hematopoietic stem cell transplantation (HSCT) recipients represent a diagnostic and therapeutic…”
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Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia by Ottaviano, Giorgio, Georgiadis, Christos, Gkazi, Soragia Athina, Syed, Farhatullah, Zhan, Hong, Etuk, Annie, Preece, Roland, Chu, Jan, Kubat, Agnieszka, Adams, Stuart, Veys, Paul, Vora, Ajay, Rao, Kanchan, Qasim, Waseem

“…Genome editing of allogeneic T cells can provide "off-the-shelf" alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T…”
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Longitudinal Assessment of Pubertal Attainment and Testicular Function Following Pediatric Hematopoietic Stem Cell Transplantation: The Role of the Conditioning Regimen by Cattoni, Alessandro, Nicolosi, Maria Laura, Capitoli, Giulia, Gadda, Alberto, Molinari, Silvia, Sotiri, Louka, Buonsante, Andrea, Orlandi, Simona, Vendemini, Francesca, Ottaviano, Giorgio, Gaiero, Alberto, Fichera, Graziella, Biondi, Andrea, Balduzzi, Adriana

“…Introduction. Endocrine disorders and impaired gonadal function are the most frequent sequelae after transplantation. Methods. Male patients <18 years…”
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Ocular Manifestations of Paediatric Inflammatory Bowel Disease: A Systematic Review and Meta-analysis by Ottaviano, Giorgio, Salvatore, Silvia, Salvatoni, Alessandro, Martelossi, Stefano, Ventura, Alessandro, Naviglio, Samuele

“…Abstract Background and Aims Ocular extraintestinal manifestations [O-EIMs] are known complications of Crohn’s disease [CD], ulcerative colitis [UC], and…”
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Cytokine release syndrome after CAR infusion in pediatric patients with refractory/relapsed B-ALL: is there a role for diclofenac? by Napolitano, Sara, Ottaviano, Giorgio, Bettini, Laura, Russotto, Vincenzo, Bonanomi, Sonia, Rovelli, Attilio, Biondi, Andrea, Rona, Roberto, Balduzzi, Adriana

“…Background: Cytokine release syndrome (CRS) is a major complication after chimeric-antigen receptor T-cell treatment, characterized by an uncontrolled systemic…”
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Vaccines and allergy: Back to the right places by Moschese, Viviana, Montin, Davide, Ottaviano, Giorgio, Sgrulletti, Mayla, Beni, Alessandra, Costagliola, Giorgio, Sangerardi, Maria, Santilli, Veronica, Miraglia Del Giudice, Michele, Rizzo, Caterina, Martire, Baldassarre

“…Hypersensitivity reactions represent one of the most common causes of hesitancy for adherence to national vaccination programs. The majority of…”
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New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies by Elfeky, Reem, Shah, Ravi M., Unni, Mohamed N.M., Ottaviano, Giorgio, Rao, Kanchan, Chiesa, Robert, Amrolia, Persis, Worth, Austen, Flood, Terry, Abinun, Mario, Hambleton, Sophie, Cant, Andrew J., Gilmour, Kimberly, Adams, Stuart, Ahsan, Gul, Barge, Dawn, Gennery, Andrew R., Qasim, Waseem, Slatter, Mary, Veys, Paul

“…Mismatched stem cell transplantation is associated with a high risk of graft loss, graft-versus-host disease (GvHD), and transplant-related mortality…”
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TT52CAR19: Phase 1 Trial of CRISPR/Cas9 Edited Allogeneic CAR19 T Cells for Paediatric Relapsed/Refractory B-ALL by Ottaviano, Giorgio, Georgiadis, Christos, Syed, Farhatullah, Gkazi, Soragia Athina, Zhan, Hong, Etuk, Annie, Chu, Jan, Pinner, Danielle, Inglott, Sarah, Gilmour, Kimberly, Adams, Stuart, Kricke, Susanne, Izotova, Natalia, Ladon, Dariusz, Kubat, Agnieszka, Veys, Paul, Vora, Ajay, Rao, Kanchan, Qasim, Waseem

“…Background ‘Off-the-shelf’ CAR T cell therapies are being investigated as alternatives to autologous CAR therapy, and can be generated using genome editing…”
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Delaying haematopoietic stem cell transplantation in children with viral respiratory infections reduces transplant‐related mortality by Ottaviano, Giorgio, Lucchini, Giovanna, Breuer, Judith, Furtado‐Silva, Juliana M., Lazareva, Arina, Ciocarlie, Oana, Elfeky, Reem, Rao, Kanchan, Amrolia, Persis J., Veys, Paul, Chiesa, Robert

“…Summary Viral respiratory infections (VRIs) contribute to the morbidity and transplant‐related mortality (TRM) after allogeneic haematopoietic stem cell…”
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Novel artful applications of vaccines at the horizon by Montin, Davide, Ottaviano, Giorgio, Sangerardi, Maria, Sgrulletti, Mayla, Chini, Loredana, Dellepiane, Rosa Maria, Martire, Baldassarre, Rizzo, Caterina, Moschese, Viviana, Marseglia, Gian Luigi

“…Some live vaccines, particularly Bacillus Calmette‐Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all‐cause mortality…”
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