Search Results - "Ottanà, Rosaria"

Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions by Maccari, Rosanna, Ottanà, Rosaria

“…Aldose reductase (AR) is an aldo–keto reductase that has been widely investigated as an enzyme crucially involved in the pathogenesis of chronic complications…”
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Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine by Maccari, Rosanna, Ottanà, Rosaria

“…Protein tyrosine phosphatase 1B (PTP1B) is an enzyme crucially implicated in aberrations of various signaling pathways that underlie the development of…”
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In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors by Maccari, Rosanna, Corso, Antonella Del, Giglio, Marco, Moschini, Roberta, Mura, Umberto, Ottanà, Rosaria

“…2-Thioxo-4-thiazolidinone derivatives were evaluated as aldose reductase inhibitors (ARIs) and most of them exhibited good or excellent in vitro efficacy. Out…”
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In vitro advanced antimycobacterial screening of isoniazid-related hydrazones, hydrazides and cyanoboranes: Part 14 by Maccari, Rosanna, Ottanà, Rosaria, Vigorita, Maria Gabriella

“…The in vitro antimycobacterial activities of some isoniazid derivatives are reported. As a part of an ongoing search for new isoniazid-related…”
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In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I by Ottanà, Rosaria, Carotti, Stefania, Maccari, Rosanna, Landini, Ida, Chiricosta, Giuseppa, Caciagli, Barbara, Vigorita, Maria Gabriella, Mini, Enrico

“…The characterization of two cyclooxygenase isoforms (COX), the rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid, has…”
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5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents by Ottanà, Rosaria, Maccari, Rosanna, Barreca, Maria Letizia, Bruno, Giuseppe, Rotondo, Archimede, Rossi, Antonietta, Chiricosta, Giuseppa, Di Paola, Rosanna, Sautebin, Lidia, Cuzzocrea, Salvatore, Vigorita, Maria Gabriella

“…[Display omitted] The synthesis and pharmacological activity of 5-arylidene-2-imino-4-thiazolidinones ( 3a– 8a) are described. All derivatives exhibited…”
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Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Rakowitz, Dietmar, Matuszczak, Barbara, Laggner, Christian, Langer, Thierry

“…In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously…”
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Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives by Maccari, Rosanna, Ottanà, Rosaria

“…Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently approved class of oral antidiabetic drugs. SGLT-2 overexpression in…”
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Identification of new non-carboxylic acid containing inhibitors of aldose reductase by Maccari, Rosanna, Ciurleo, Rosella, Giglio, Marco, Cappiello, Mario, Moschini, Roberta, Corso, Antonella Del, Mura, Umberto, Ottanà, Rosaria

“…New non-carboxylic acid containing 5-arylidene-2,4-thiazolidinedione derivatives have been identified as aldose reductase inhibitors active at low micromolar…”
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Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…A number of 5-arylidene-2,4-thiazolidinediones containing a hydroxy or a carboxymethoxy group in their 5-benzylidene moiety have been synthesised and evaluated…”
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Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors by Maccari, Rosanna, Ottanà, Rosaria, Curinga, Carmela, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…[Display omitted] The structure–activity relationships (SARs) of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors (ARIs) were extended…”
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In Vitro Antimycobacterial Activities of 2′-Monosubstituted Isonicotinohydrazides and Their Cyanoborane Adducts by MACCARI, Rosanna, OTTANA, Rosaria, MONFORTE, Francesca, VIGORITA, Maria Gabriella

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures by Panico, Annamaria, Maccari, Rosanna, Cardile, Venera, Crasci, Lucia, Ronsisvalle, Simone, Ottanà, Rosaria

“…5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by…”
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In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones by Rakowitz, Dietmar, Maccari, Rosanna, Ottanà, Rosaria, Vigorita, Maria Gabriella

“…Several 5-benzyl-2,4-thiazolidinediones ( 5– 7) were synthesised and tested as in vitro aldose reductase (ALR2) inhibitors. Most of them, particularly…”
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In vitro advanced antimycobacterial screening of cobalt(II) and copper(II) complexes of fluorinated isonicotinoylhydrazones by Maccari, Rosanna, Ottanà, Rosaria, Bottari, Bruno, Rotondo, Enrico, Vigorita, Maria Gabriella

“…The in vitro antimycobacterial activities of metalcomplexes 1, 2 are reported. The in vitro antimycobacterial activity of cobalt(II) and copper(II) complexes…”
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Low Molecular Weight Phosphotyrosine Protein Phosphatases as Emerging Targets for the Design of Novel Therapeutic Agents by Maccari, Rosanna, Ottanà, Rosaria

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Extending the investigation of 4-thiazolidinone derivatives as potential multi-target ligands of enzymes involved in diabetes mellitus and its long-term complications: A study with pancreatic α-amylase by Szabó, Kármen, Maccari, Rosanna, Ottanà, Rosaria, Gyémánt, Gyöngyi

“…Diabetes mellitus is a multifactorial disease, which is frequently complicated by the development of hyperglycaemia-induced chronic complications. The therapy…”
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An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications by Maccari, Rosanna, Del Corso, Antonella, Paoli, Paolo, Adornato, Ilenia, Lori, Giulia, Balestri, Francesco, Cappiello, Mario, Naß, Alexandra, Wolber, Gerhard, Ottanà, Rosaria

“…[Display omitted] •4-Thiazolidinones were synthesised and tested as dual AR/PTP1B inhibitors.•SAR, molecular docking and kinetic studies were carried out.•Two…”
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Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors by Maccari, Rosanna, Wolber, Gerhard, Genovese, Massimo, Sardelli, Gemma, Talagayev, Valerij, Balestri, Francesco, Luti, Simone, Santi, Alice, Moschini, Roberta, Del Corso, Antonella, Paoli, Paolo, Ottanà, Rosaria

“…Type 2 diabetes mellitus (T2DM) is a serious chronic disease with an alarmingly growing worldwide prevalence. Current treatment of T2DM mainly relies on drug…”
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In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B by Ottanà, Rosaria, Paoli, Paolo, Cappiello, Mario, Nguyen, Trung Ngoc, Adornato, Ilenia, Del Corso, Antonella, Genovese, Massimo, Nesi, Ilaria, Moschini, Roberta, Naß, Alexandra, Wolber, Gerhard, Maccari, Rosanna

“…Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its…”
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