Search Results - "Ott, Vanessa L"

Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors by Crute, Bergren W, Sheraden, Rachel, Ott, Vanessa L, Harley, Isaac T W, Getahun, Andrew, Cambier, John C

“…Among the areas of most impactful recent progress in immunology is the discovery of inhibitory receptors and the subsequent translation of this knowledge to…”
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Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention? by Ott, Vanessa L., Cambier, John C.

“…Immune responses are tightly controlled by the activities of both activating and inhibitory signals. At the cellular level, these signals are generated through…”
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Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4 by Ott, Vanessa L, Cambier, John C, Kappler, John, Marrack, Philippa, Swanson, Bradley J

“…Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T…”
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Effector CD8 + T cells mediate inflammation and airway hyper-responsiveness by Gelfand, Erwin W, Miyahara, Nobuaki, Swanson, Bradley J, Takeda, Katsuyuki, Taube, Christian, Miyahara, Satoko, Kodama, Taku, Dakhama, Azzeddine, Ott, Vanessa L

“…Allergic asthma is a complex syndrome characterized by airway obstruction, airway inflammation and airway hyper-responsiveness (AHR). Using a mouse model of…”
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Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors by Cady, Carol T, Rice, Jeffrey S, Ott, Vanessa L, Cambier, John C

“…Numerous autoimmune and inflammatory disorders stem from the dysregulation of hematopoietic cell activation. The activity of inositol lipid and protein…”
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Molecular interactions of the syndecan core proteins by Rapraeger, Alan C, Ott, Vanessa L

“…The syndecan family of cell-surface heparan sulfate proteoglycans participate in multiple cell behaviors ranging from growth factor signaling to cell adhesion…”
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Tyrosine Phosphorylation of Syndecan-1 and -4 Cytoplasmic Domains in Adherent B82 Fibroblasts by Ott, V L, Rapraeger, A C

“…The syndecans, a family of cell surface proteoglycans, have highly conserved cytoplasmic domains that bind proteins containing PDZ domains and co-localize with…”
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FcγRIIB as a potential molecular target for intravenous gamma globulin therapy by Ott, Vanessa L., Fong, Dana C., Cambier, John C.

“…The ability of the immune system to respond appropriately to foreign antigen is dependent on a delicate balance of activating and inhibitory signals. Recently,…”
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Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling by Ott, Vanessa L, Cambier, John C

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Mast cell-dependent migration of effector CD8 + T cells through production of leukotriene B 4 by Ott, Vanessa L, Cambier, John C, Kappler, John, Marrack, Philippa, Swanson, Bradley J

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Type Iγ PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil Chemotaxis by Lokuta, Mary A., Senetar, Melissa A., Bennin, David A., Nuzzi, Paul A., Chan, Keefe T., Ott, Vanessa L., Huttenlocher, Anna

“…Cell polarization is necessary for directed migration and leukocyte recruitment to inflamed tissues. Recent progress has been made in defining the molecular…”
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Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors: Inhibition of Immune Cell Function by CADY, Carol T, RICE, Jeffrey S, OTT, Vanessa L, CAMBIER, John C

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Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis by Lokuta, Mary A, Senetar, Melissa A, Bennin, David A, Nuzzi, Paul A, Chan, Keefe T, Ott, Vanessa L, Huttenlocher, Anna

“…Cell polarization is necessary for directed migration and leukocyte recruitment to inflamed tissues. Recent progress has been made in defining the molecular…”
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Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1 by Reiland, J, Ott, V L, Lebakken, C S, Yeaman, C, McCarthy, J, Rapraeger, A C

“…Syndecan-1 is a transmembrane haparan sulphate proteoglycan that binds extracellular matrices and growth factors, making it a candidate to act between these…”
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Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent by Forrester, K, Lupold, S E, Ott, V L, Chay, C H, Band, V, Wang, X W, Harris, C C

“…The spectrum of p53 mutations differs among human cancer types. We have hypothesized that the p53 mutational spectrum observed in particular tumor types…”
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Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling by Ott, Vanessa L, Tamir, Idan, Niki, Masaru, Pandolfi, Pier Paolo, Cambier, John C

“…The low-affinity receptor for IgG, Fc gamma RIIB, is expressed widely in the immune system and functions to attenuate Ag-induced immune responses. In mast…”
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Downstream of Kinase, p62 dok , Is a Mediator of FcγRIIB Inhibition of FcεRI Signaling by Ott, Vanessa L., Tamir, Idan, Niki, Masaru, Pandolfi, Pier Paolo, Cambier, John C.

“…Abstract The low-affinity receptor for IgG, FcγRIIB, is expressed widely in the immune system and functions to attenuate Ag-induced immune responses. In mast…”
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Downstream of Kinase, p62dok, Is a Mediator of Fc{gamma}RIIB Inhibition of Fc{epsilon}RI Signaling by Ott, Vanessa L, Tamir, Idan, Niki, Masaru, Pandolfi, Pier Paolo, Cambier, John C

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