Search Results - "Ott, Melanie"

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond by Verdin, Eric, Ott, Melanie

“…The year 2014 marks the 50th anniversary of the discovery of protein acetylation. In this Timeline article, Verdin and Ott discuss the identification of this…”
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Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics by Ali, Ibraheem, Conrad, Ryan J, Verdin, Eric, Ott, Melanie

“…Post-translational acetylation of lysine residues has emerged as a key regulatory mechanism in all eukaryotic organisms. Originally discovered in 1963 as a…”
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The Control of HIV Transcription: Keeping RNA Polymerase II on Track by Ott, Melanie, Geyer, Matthias, Zhou, Qiang

“…Thirteen years ago, human cyclin T1 was identified as part of the positive transcription elongation factor b (P-TEFb) and the long-sought host cofactor for the…”
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Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology by Simoneau, Camille R., Ott, Melanie

“…SARS-CoV-2, the virus causing the current COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respiratory distress…”
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Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles by Syed, Abdullah M, Taha, Taha Y, Tabata, Takako, Chen, Irene P, Ciling, Alison, Khalid, Mir M, Sreekumar, Bharath, Chen, Pei-Yi, Hayashi, Jennifer M, Soczek, Katarzyna M, Ott, Melanie, Doudna, Jennifer A

“…Efforts to determine why new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants demonstrate improved fitness have been limited to analyzing…”
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The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes by Conrad, Ryan J., Fozouni, Parinaz, Thomas, Sean, Sy, Hendrik, Zhang, Qiang, Zhou, Ming-Ming, Ott, Melanie

“…BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment paradoxically reactivates latent HIV-1 transcription. Here…”
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Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants by Servellita, Venice, Syed, Abdullah M., Morris, Mary Kate, Brazer, Noah, Saldhi, Prachi, Garcia-Knight, Miguel, Sreekumar, Bharath, Khalid, Mir M., Ciling, Alison, Chen, Pei-Yi, Kumar, G. Renuka, Gliwa, Amelia S., Nguyen, Jenny, Sotomayor-Gonzalez, Alicia, Zhang, Yueyuan, Frias, Edwin, Prostko, John, Hackett, John, Andino, Raul, Wadford, Debra A., Hanson, Carl, Doudna, Jennifer, Ott, Melanie, Chiu, Charles Y.

“…Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples…”
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The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11 by Boehm, Daniela, Lam, Victor, Schnolzer, Martina, Ott, Melanie

“…A successful HIV-1 cure strategy may require enhancing HIV-1 latency to silence HIV-1 transcription. Modulators of gene expression show promise as…”
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Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles by Syed, Abdullah M., Ciling, Alison, Taha, Taha Y., Chen, Irene P., Khalid, Mir M., Sreekumar, Bharath, Chen, Pei-Yi, Kumar, G. Renuka, Suryawanshi, Rahul, Silva, Ines, Milbes, Bilal, Kojima, Noah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Spraggon, Lee, Tabata, Takako, Ott, Melanie, Doudna, Jennifer A.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant contains extensive sequence changes relative to the earlier-arising B.1,…”
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Viral Hijacking of BET Proteins by Chen, Irene P, Ott, Melanie

“…Proteins of the bromodomain and exterminal domain (BET) family mediate critical host functions such as cell proliferation, transcriptional regulation, and the…”
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Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy by Min, Sang-Won, Cho, Seo-Hyun, Zhou, Yungui, Schroeder, Sebastian, Haroutunian, Vahram, Seeley, William W., Huang, Eric J., Shen, Yong, Masliah, Eliezer, Mukherjee, Chandrani, Meyers, David, Cole, Philip A., Ott, Melanie, Gan, Li

“…Neurodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and…”
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Tropism of SARS-CoV-2 for human cortical astrocytes by Andrews, Madeline G, Mukhtar, Tanzila, Eze, Ugomma C, Simoneau, Camille R, Ross, Jayden, Parikshak, Neelroop, Wang, Shaohui, Zhou, Li, Koontz, Mark, Velmeshev, Dmitry, Siebert, Clara-Vita, Gemenes, Kaila M, Tabata, Takako, Perez, Yonatan, Wang, Li, Mostajo-Radji, Mohammed A, de Majo, Martina, Donohue, Kevin C, Shin, David, Salma, Jahan, Pollen, Alex A, Nowakowski, Tomasz J, Ullian, Erik, Kumar, G Renuka, Winkler, Ethan A, Crouch, Elizabeth E, Ott, Melanie, Kriegstein, Arnold R

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with…”
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Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons by Kong, Weili, Montano, Mauricio, Corley, Michael J, Helmy, Ekram, Kobayashi, Hirofumi, Kinisu, Martin, Suryawanshi, Rahul, Luo, Xiaoyu, Royer, Loic A, Roan, Nadia R, Ott, Melanie, Ndhlovu, Lishomwa C, Greene, Warner C

“…Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Taking cues from convalescence to improve vaccines against hepatitis C virus by Sreekumar, Bharath K, Taha, Taha Y, Ott, Melanie

“…Hepatitis C virus (HCV) infection remains a worldwide public health issue despite direct-acting antivirals. A substantial proportion of infected individuals…”
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A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo by Taha, Taha Y, Suryawanshi, Rahul K, Chen, Irene P, Correy, Galen J, McCavitt-Malvido, Maria, O'Leary, Patrick C, Jogalekar, Manasi P, Diolaiti, Morgan E, Kimmerly, Gabriella R, Tsou, Chia-Lin, Gascon, Ronnie, Montano, Mauricio, Martinez-Sobrido, Luis, Krogan, Nevan J, Ashworth, Alan, Fraser, James S, Ott, Melanie

“…Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting…”
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Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1 by Ott, Melanie, Herker, Eva, Harris, Charles, Hernandez, Céline, Carpentier, Arnaud, Kaehlcke, Katrin, Rosenberg, Arielle R, Farese, Robert V

“…Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol…”
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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo by Miao, Yi, Ha, Andrew, de Lau, Wim, Yuki, Kanako, Santos, António J.M., You, Changjiang, Geurts, Maarten H., Puschhof, Jens, Pleguezuelos-Manzano, Cayetano, Peng, Weng Chuan, Senlice, Ramazan, Piani, Carol, Buikema, Jan W., Gbenedio, Oghenekevwe M., Vallon, Mario, Yuan, Jenny, de Haan, Sanne, Hemrika, Wieger, Rösch, Kathrin, Dang, Luke T., Baker, David, Ott, Melanie, Depeille, Philippe, Wu, Sean M., Drost, Jarno, Nusse, Roeland, Roose, Jeroen P., Piehler, Jacob, Boj, Sylvia F., Janda, Claudia Y., Clevers, Hans, Kuo, Calvin J., Garcia, K. Christopher

“…Modulation of Wnt signaling has untapped potential in regenerative medicine due to its essential functions in stem cell homeostasis. However, Wnt lipidation…”
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Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1 by Li, Zichong, Deeks, Steven G., Ott, Melanie, Greene, Warner C.

“…Host repressors mediate HIV latency, but how they interactively silence the virus remains unclear. Here, we develop “reiterative enrichment and authentication…”
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Nuclear accumulation of host transcripts during Zika Virus Infection by Leon, Kristoffer E, Khalid, Mir M, Flynn, Ryan A, Fontaine, Krystal A, Nguyen, Thong T, Kumar, G Renuka, Simoneau, Camille R, Tomar, Sakshi, Jimenez-Morales, David, Dunlap, Mariah, Kaye, Julia, Shah, Priya S, Finkbeiner, Steven, Krogan, Nevan J, Bertozzi, Carolyn, Carette, Jan E, Ott, Melanie

“…Zika virus (ZIKV) infects fetal neural progenitor cells (NPCs) causing severe neurodevelopmental disorders in utero. Multiple pathways involved in normal brain…”
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Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6 by Taha, Taha Y., Chen, Irene P., Hayashi, Jennifer M., Tabata, Takako, Walcott, Keith, Kimmerly, Gabriella R., Syed, Abdullah M., Ciling, Alison, Suryawanshi, Rahul K., Martin, Hannah S., Bach, Bryan H., Tsou, Chia-Lin, Montano, Mauricio, Khalid, Mir M., Sreekumar, Bharath K., Renuka Kumar, G., Wyman, Stacia, Doudna, Jennifer A., Ott, Melanie

“…Although the SARS-CoV-2 Omicron variant (BA.1) spread rapidly across the world and effectively evaded immune responses, its viral fitness in cell and animal…”
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