Search Results - "Ott, Ingo"

On the medicinal chemistry of gold complexes as anticancer drugs by Ott, Ingo

“…Metal complexes have shown interesting preclinical and clinical results as antitumor drugs and platinum compounds are well established in current cancer…”
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N-Heterocyclic carbene metal complexes in medicinal chemistry by Oehninger, Luciano, Rubbiani, Riccardo, Ott, Ingo

“…Metal complexes with N-heterocyclic carbene (NHC) ligands are widely used in chemistry due to their catalytic properties and applied for olefin metathesis…”
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Non Platinum Metal Complexes as Anti-cancer Drugs by Ott, Ingo, Gust, Ronald

“…The development of metal complexes with platinum central atoms such as cisplatin or carboplatin had an enormous impact on current cancer chemotherapy. However,…”
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Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro by Wilke, Nicola L, Burmeister, Hilke, Frias, Corazon, Ott, Ingo, Prokop, Aram

“…Ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands have recently attracted attention as novel chemotherapeutic agents. The complex HB324 was…”
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Highly Electrophilic, Catalytically Active and Redox‐Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes by Vanicek, Stefan, Podewitz, Maren, Stubbe, Jessica, Schulze, Dennis, Kopacka, Holger, Wurst, Klaus, Müller, Thomas, Lippmann, Petra, Haslinger, Simone, Schottenberger, Herwig, Liedl, Klaus R., Ott, Ingo, Sarkar, Biprajit, Bildstein, Benno

“…A convenient access to a triad of triazoles with ferrocenyl and cobaltoceniumyl substituents is reported. N‐Alkylation, deprotonation and metalation with…”
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Cyclometalated Pt Complexes of CNC Pincer Ligands: Luminescence and Cytotoxic Evaluation by Garbe, Simon, Krause, Maren, Klimpel, Annika, Neundorf, Ines, Lippmann, Petra, Ott, Ingo, Brünink, Dana, Strassert, Cristian A, Doltsinis, Nikos L, Klein, Axel

“…In the framework of our attempts to develop cyclometalated Pt­(II) complexes toward bifunctional targeting inhibitors or agents for photodynamic therapy,…”
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Evaluation of Ruthenium(II) N -Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase by Burmeister, Hilke, Dietze, Pascal, Preu, Lutz, Bandow, Julia E, Ott, Ingo

“…A series of ruthenium(II) complexes with -heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(II)X (where X = halide) was prepared,…”
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On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes by Meyer, Andreas, Bagowski, Christoph P., Kokoschka, Malte, Stefanopoulou, Maria, Alborzinia, Hamed, Can, Suzan, Vlecken, Danielle H., Sheldrick, William S., Wölfl, Stefan, Ott, Ingo

“…Golden times for metal‐based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future…”
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A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells by Cheng, Xinlai, Holenya, Palvo, Can, Suzan, Alborzinia, Hamed, Rubbiani, Riccardo, Ott, Ingo, Wölfl, Stefan

“…Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress…”
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Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex by Niesel, Johanna, Pinto, Antonio, Peindy N'Dongo, Harmel W, Merz, Klaus, Ott, Ingo, Gust, Ronald, Schatzschneider, Ulrich

“…Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)(3)(tpm)]PF(6) revealed a significant photoinduced cytotoxicity…”
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Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N-Heterocyclic Carbene Complexes Bearing Charged Substituents by Simpson, Peter V., Schmidt, Claudia, Ott, Ingo, Bruhn, Heike, Schatzschneider, Ulrich

“…Four new N‐heterocyclic carbene (NHC) rhodium and iridium complexes decorated with anionic or cationic pendant groups to increase their water solubility and…”
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A Chemical-Biological Evaluation of Rhodium(I) N-Heterocyclic Carbene Complexes as Prospective Anticancer Drugs by Oehninger, Luciano, Küster, Laura Nadine, Schmidt, Claudia, Muñoz-Castro, Alvaro, Prokop, Aram, Ott, Ingo

“…Rhodium(I) complexes bearing N‐heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological…”
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Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands by Streciwilk, Wojciech, Terenzi, Alessio, Lo Nardo, Federico, Prochnow, Pascal, Bandow, Julia Elisabeth, Keppler, Bernhard K., Ott, Ingo

“…Organometallic N‐heterocyclic carbene (NHC) complexes with intercalating bis‐naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects…”
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A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action by Zhang, Jing-Jing, Muenzner, Julienne K, Abu El Maaty, Mohamed A, Karge, Bianka, Schobert, Rainer, Wölfl, Stefan, Ott, Ingo

“…A rhodium(i) and a ruthenium(ii) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic…”
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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype by Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad

“…Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other…”
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A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway by Dabiri, Yasamin, Schmid, Alice, Theobald, Jannick, Blagojevic, Biljana, Streciwilk, Wojciech, Ott, Ingo, Wölfl, Stefan, Cheng, Xinlai

“…The p38 MAPK pathway is known to influence the anti-tumor effects of several chemotherapeutics, including that of organometallic drugs. Previous studies have…”
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From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents by Lam, Nelson Y. S, Truong, Dianna, Burmeister, Hilke, Babak, Maria V, Holtkamp, Hannah U, Movassaghi, Sanam, Ayine-Tora, Daniel Moscoh, Zafar, Ayesha, Kubanik, Mario, Oehninger, Luciano, Söhnel, Tilo, Reynisson, Jóhannes, Jamieson, Stephen M. F, Gaiddon, Christian, Ott, Ingo, Hartinger, Christian G

“…The promise of the metal­(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic…”
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Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics by Wenzel, Michaela, Patra, Malay, Senges, Christoph Helmut Rudi, Ott, Ingo, Stepanek, Jennifer Janina, Pinto, Antonio, Prochnow, Pascal, Vuong, Cuong, Langklotz, Sina, Metzler-Nolte, Nils, Bandow, Julia Elisabeth

“…Two hetero-tri-organometallic compounds with potent activity against Gram-positive bacteria including multi-resistant Staphylococcus aureus (MRSA) were…”
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FeIII, CuII and ZnII Complexes of the Rigid 9-Oxido-phenalenone Ligand—Spectroscopy, Electrochemistry, and Cytotoxic Properties by Butsch, Katharina, Haseloer, Alexander, Schmitz, Simon, Ott, Ingo, Schur, Julia, Klein, Axel

“…The three complexes [Fe(opo)3], [Cu(opo)2], and [Zn(opo)2] containing the non-innocent anionic ligand opo− (opo− = 9-oxido-phenalenone, Hopo =…”
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Crystal structures of the gold NHC complex bis(4-bromo-1,3-diethylimidazol-2-ylidene)gold(I) iodide and its 1:1 adduct with trans -bis(4-bromo-1,3-diethyl-imidazol-2-ylidene)diiodidogold(III) iodide by Büssing, Rolf, Ott, Ingo, Jones, Peter G.

“…The first title compound, [Au(C 7 H 11 BrN 2 ) 2 ]I, crystallizes in the space group P \overline{1} without imposed symmetry. The cations and anions are linked…”
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