Search Results - "Otsuka, Makoto"

Modeling of feed-forward control using the partial least squares regression method in the tablet compression process by Hattori, Yusuke, Otsuka, Makoto

“…[Display omitted] In the pharmaceutical industry, the implementation of continuous manufacturing has been widely promoted in lieu of the traditional batch…”
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Detection of Impurities in Organic Crystals by High-Accuracy Terahertz Absorption Spectroscopy by Sasaki, Tetsuo, Sakamoto, Tomoaki, Otsuka, Makoto

“…Quantitative detection of impurities in organic crystals was demonstrated by accurately measuring absorption frequencies using a continuous wave gallium…”
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Application of spray freeze drying to theophylline-oxalic acid cocrystal engineering for inhaled dry powder technology by Tanaka, Ryoma, Hattori, Yusuke, Otsuka, Makoto, Ashizawa, Kazuhide

“…Spray freeze drying (SFD) produces suitable particles for the pharmaceutical formulation of dry powders used in dry powder inhalers (DPIs). However, SFD…”
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Non-destructive prediction of enteric coating layer thickness and drug dissolution rate by near-infrared spectroscopy and X-ray computed tomography by Ariyasu, Aoi, Hattori, Yusuke, Otsuka, Makoto

“…[Display omitted] The coating layer thickness of enteric-coated tablets is a key factor that determines the drug dissolution rate from the tablet…”
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Dissolution process analysis using model-free Noyes–Whitney integral equation by Hattori, Yusuke, Haruna, Yoshimasa, Otsuka, Makoto

“…[Display omitted] ► We derived model-free Noyes–Whitney integral equation. ► Various drug dissolution profiles were well-represented by the integral equation…”
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MCR-ALS analysis of IR spectroscopy and XRD for the investigation of ibuprofen - nicotinamide cocrystal formation by Ishihara, Sae, Hattori, Yusuke, Otsuka, Makoto

“…To improve aqueous solubility, a poorly water-soluble active ingredient is classically combined with a conformer to form cocrystals. Hot melt extrusion is one…”
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Quantitation of trace amorphous solifenacin succinate in pharmaceutical formulations by transmission Raman spectroscopy by Terada, Hirohito, Hattori, Yusuke, Sasaki, Tetsuo, Otsuka, Makoto

“…[Display omitted] It is important to quantify amorphous solid in active pharmaceutical ingredients (API) of formulations to guarantee high-quality…”
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Device-Independent Discrimination of Falsified Amoxicillin Capsules Using Heterogeneous Near-Infrared Spectroscopic Devices for Training and Testing of a Support Vector Machine by Hattori, Yusuke, Hoshi, Yuka, Ichimura, Yasunori, Sugiura, Yasuo, Otsuka, Makoto

“…The objective of this work is to demonstrate the potential of near-infrared spectroscopy for common screening of falsified medicines in the field by means of a…”
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Application of Calcium Phosphate as a Controlled-Release Device by Ito, Tomoko, Otsuka, Makoto

“…Calcium phosphate (CaP)-based compounds are biocompatible and have been accepted as promising candidates for novel drug-releasing devices. CaP is biodegradable…”
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Analysis of the dehydration process of caffeine using backscattering and transmission Raman spectroscopy by Takeshima, Rina, Hattori, Yusuke, Managaki, Satoshi, Otsuka, Makoto

“…[Display omitted] In the present study, the dehydration process of caffeine hydrate (CAH) was investigated by calibrating the moisture content in the caffeine…”
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Real-Time Monitoring of Critical Quality Attributes during High-Shear Wet Granulation Process by Near-Infrared Spectroscopy Effect of Water Addition and Stirring Speed on Pharmaceutical Properties of the Granules by Koyanagi, Keita, Ueno, Akinori, Sasaki, Tetsuo, Otsuka, Makoto

“…To produce high-quality pharmaceuticals, a real-time monitoring method for the high-shear wet granulation process (HSWG) was developed based on near-infrared…”
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Characteristic evaluation of the pseudo-polymorphism of amorphous atorvastatin calcium hydrates by terahertz spectroscopy by Kobayashi, Makiko, Hattori, Yusuke, Sasaki, Tetsuo, Nishizawa, Jun-ichi, Otsuka, Makoto

“…In order to scientifically elucidate the difference in the dissolution characteristics of crystalline atorvastatin calcium (ATCH) and the amorphous ATC solids…”
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医薬品製造工程管理の進歩─物理薬剤学から医薬品自動生産へ─（粉屋のたしなみ） by 大塚, 誠

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Near-infrared spectroscopy-based nondestructive at-line analysis of physicochemical properties of atorvastatin calcium hydrate after grinding by Kobayashi, Makiko, Hattori, Yusuke, Sasaki, Tetsuo, Otsuka, Makoto

“…The purpose of this study was to monitor the physicochemical properties of atorvastatin calcium sesquihydrate (ATC) ground products during grinding and to…”
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Analytical Evaluation of Wet and Dry Mechanochemical Syntheses of Calcium-Deficient Hydroxyapatite Containing Zinc Using X-ray Diffractometry and Near-Infrared Spectroscopy by Otsuka, Makoto, Saito, Hanae, Sasaki, Tetsuo

“…Calcium-deficient zinc-containing calcium phosphate (ZnAP), which has sustained zinc release properties that are effective for treating osteoporosis, can be…”
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Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets by Abe, Hiroyuki, Otsuka, Makoto

“…The relationship between lubricant-mixing time and dissolution time was investigated, and we established a calibration model to predict dissolution time by…”
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Precise Evaluation of the Effects of a Small Amount of D-histidine in L-histidine Crystal Form B Using High-Frequency-Accurate Terahertz Spectroscopy by Sasaki, Tetsuo, Sakamoto, Tomoaki, Otsuka, Makoto

“…The effects of small amounts of enantiomeric impurities on the vibrational modes of polycrystalline L-histidine (His) were examined using…”
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Algorithm and hyperparameter optimizations for hetero-device classification by near-infrared spectra of falsified and substandard amoxicillin capsules by Hattori, Yusuke, Hoshi, Yuka, Hashimoto, Naofumi, Ichimura, Yasunori, Sugiura, Yasuo, Otsuka, Makoto

“…In this work, we optimized classification algorithms and the hyperparameters for screening falsified and substandard amoxicillin capsules. The distribution of…”
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ATR/FT-IR and NIR Auto-correlation Spectroscopic Analysis of Powder Blending Uniformity of Low-content Magnesium Stearate and Potato Starch by HATTORI, Yusuke, OTSUKA, Makoto

“…Here, we report on near-infrared and ATR/FT-IR spectroscopic measurements of magnesium stearate and potato starch powder blends. In the pharmaceutical and food…”
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Comparative particle size determination of phenacetin bulk powder by using Kubelka–Munk theory and principal component regression analysis based on near-infrared spectroscopy by Otsuka, Makoto

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